Home / Gene
ABCB11
receptor: FXRTier 1
CAMIP causal chains
FXR
Disrupted receptor-mediated transactivation via the FXR/RXRα heterodimer, abolishing the critical canalicular expression of the Bile Salt Export Pump. This directly cripples the ATP-dependent rate-limiting step of hepatic bile acid elimination, precipitating toxic intracellular bile salt accumulation and rendering hepatocytes profoundly vulnerable to severe drug-induced cholestatic liver injury under medications such as bosentan and cyclosporine.
Affected substrate drugs (PharmGKB): bosentan; cyclosporine; estrogens
Scored variants near ABCB11
chr2:168,820,780..169,131,324, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr2_169031334_A_G | chr2:169031334 | 47,712 | 18,976 | 20,864 | — |
| chr2_169031340_A_G | chr2:169031340 | 45,248 | 20,960 | 20,736 | — |
| chr2_169031342_T_C | chr2:169031342 | 31,552 | 12,416 | 16,256 | — |
| chr2_169031312_T_A | chr2:169031312 | 22,336 | 14,352 | 31,872 | — |
| chr2_169031317_A_G | chr2:169031317 | 21,120 | 9,120 | 10,496 | — |
| chr2_169031312_T_G | chr2:169031312 | 19,584 | 11,536 | 25,216 | — |
| chr2_169031343_C_G | chr2:169031343 | 18,880 | 6,848 | 12,096 | — |
| chr2_169031315_T_G | chr2:169031315 | 18,016 | 9,472 | 15,104 | — |
| chr2_169031224_C_G | chr2:169031224 | -15,744 | -7,584 | -13,440 | — |
| chr2_169031254_G_T | chr2:169031254 | 15,680 | 6,112 | 6,272 | — |
| chr2_169031341_T_G | chr2:169031341 | 15,680 | 7,680 | 6,912 | — |
| chr2_169031224_C_A | chr2:169031224 | -15,552 | -7,312 | -14,400 | — |
| chr2_169031326_A_T | chr2:169031326 | -14,400 | -6,880 | -11,520 | — |
| chr2_169031282_A_C | chr2:169031282 | 14,080 | 7,072 | 6,528 | — |
| chr2_169031223_A_C | chr2:169031223 | -13,952 | -6,400 | -14,592 | — |
| chr2_169031338_G_T | chr2:169031338 | -13,792 | -6,912 | -8,960 | — |
| chr2_169031225_C_A | chr2:169031225 | -13,568 | -6,336 | -9,920 | — |
| chr2_169031223_A_T | chr2:169031223 | -13,504 | -5,952 | -13,056 | — |
| chr2_169031308_T_C | chr2:169031308 | 13,248 | 6,208 | 6,912 | — |
| chr2_169031290_T_C | chr2:169031290 | -12,800 | -8,128 | -11,008 | — |
| chr2_169031315_T_C | chr2:169031315 | -12,672 | -6,336 | -11,712 | — |
| chr2_169031314_T_C | chr2:169031314 | -12,192 | -6,528 | -9,856 | — |
| chr2_169031312_T_C | chr2:169031312 | 11,808 | 5,264 | 11,008 | — |
| chr2_169031288_T_A | chr2:169031288 | -11,008 | -5,984 | -12,992 | — |
| chr2_169031224_C_T | chr2:169031224 | -10,944 | -5,984 | -10,496 | — |
| chr2_169031288_T_C | chr2:169031288 | -10,720 | -6,192 | -13,312 | — |
| chr2_169031292_A_G | chr2:169031292 | 10,688 | 6,944 | 9,344 | — |
| chr2_169031313_T_C | chr2:169031313 | -10,432 | -5,376 | -11,008 | — |
| chr2_169031336_C_G | chr2:169031336 | -10,432 | -4,368 | -10,304 | — |
| chr2_169031338_G_A | chr2:169031338 | -10,336 | -4,512 | -5,760 | — |
| chr2_169031302_C_G | chr2:169031302 | 10,016 | 6,464 | 9,088 | — |
| chr2_169031262_G_C | chr2:169031262 | 9,472 | 3,424 | 5,120 | — |
| chr2_169031223_A_G | chr2:169031223 | -9,408 | -4,416 | -8,640 | — |
| chr2_169031194_G_C | chr2:169031194 | 9,344 | 3,232 | 3,392 | — |
| chr2_169031308_T_G | chr2:169031308 | 9,344 | 5,632 | 8,832 | — |
| chr2_169031340_A_T | chr2:169031340 | 9,344 | 3,552 | 6,272 | — |
| chr2_169031254_G_C | chr2:169031254 | 9,216 | 3,488 | 3,840 | — |
| chr2_169031334_A_T | chr2:169031334 | -9,024 | -4,064 | -6,272 | — |
| chr2_169031333_G_T | chr2:169031333 | -8,864 | -4,128 | -6,400 | — |
| chr2_169031325_A_T | chr2:169031325 | -8,800 | -3,776 | -7,040 | — |
| chr2_169031317_A_T | chr2:169031317 | -8,768 | -3,968 | -7,168 | — |
| chr2_169031291_C_T | chr2:169031291 | -8,672 | -5,408 | -10,240 | — |
| chr2_169031336_C_A | chr2:169031336 | -8,576 | -2,864 | -9,728 | — |
| chr2_169031306_C_T | chr2:169031306 | -8,448 | -4,480 | -6,848 | — |
| chr2_169031289_T_A | chr2:169031289 | -8,384 | -5,824 | -10,048 | — |
| chr2_169031309_C_T | chr2:169031309 | -8,224 | -4,048 | -6,016 | — |
| chr2_169031226_T_C | chr2:169031226 | -8,192 | -3,424 | -4,608 | — |
| chr2_169031226_T_A | chr2:169031226 | -8,128 | -3,744 | -3,968 | — |
| chr2_169031329_C_A | chr2:169031329 | -8,128 | -3,328 | -4,928 | — |
| chr2_169031294_A_T | chr2:169031294 | -8,096 | -6,144 | -10,624 | — |
| chr2_169031225_C_T | chr2:169031225 | -8,064 | -3,840 | -3,968 | — |
| chr2_169031341_T_A | chr2:169031341 | 8,064 | 1,824 | 5,120 | — |
| chr2_169031324_T_C | chr2:169031324 | 7,776 | 3,744 | 2,944 | — |
| chr2_169031331_C_A | chr2:169031331 | -7,648 | -3,328 | -8,320 | — |
| chr2_169031295_A_T | chr2:169031295 | -7,552 | -4,064 | -11,072 | — |
| chr2_169031198_T_G | chr2:169031198 | -7,488 | -2,752 | -3,328 | — |
| chr2_169031290_T_G | chr2:169031290 | 7,424 | 3,104 | 4,352 | — |
| chr2_169031336_C_T | chr2:169031336 | -7,360 | -2,992 | -6,592 | — |
| chr2_169031343_C_A | chr2:169031343 | -7,168 | -2,416 | -5,440 | — |
| chr2_169031322_T_A | chr2:169031322 | 7,072 | 2,816 | 4,096 | — |
| chr2_169031184_A_C | chr2:169031184 | 7,040 | 2,208 | 5,760 | — |
| chr2_169031270_C_T | chr2:169031270 | -7,040 | -3,008 | -2,816 | — |
| chr2_169031342_T_A | chr2:169031342 | 6,976 | 2,656 | 4,480 | — |
| chr2_169031304_A_C | chr2:169031304 | -6,912 | -3,152 | -5,504 | — |
| chr2_169031292_A_T | chr2:169031292 | -6,848 | -4,192 | -7,040 | — |
| chr2_169031291_C_G | chr2:169031291 | -6,816 | -4,800 | -8,832 | — |
| chr2_169031320_A_C | chr2:169031320 | -6,528 | -3,776 | -6,848 | — |
| chr2_169031321_T_A | chr2:169031321 | -6,464 | -4,160 | -6,592 | — |
| chr2_169031260_A_T | chr2:169031260 | 6,464 | 1,728 | 3,072 | — |
| chr2_169031293_C_G | chr2:169031293 | -6,400 | -5,440 | -8,960 | — |
| chr2_169031309_C_A | chr2:169031309 | -6,240 | -3,776 | -4,224 | — |
| chr2_169031225_C_G | chr2:169031225 | -6,080 | -2,816 | -832 | — |
| chr2_169031339_A_G | chr2:169031339 | 6,048 | 2,400 | 4,224 | — |
| chr2_169031291_C_A | chr2:169031291 | -5,888 | -4,416 | -7,424 | — |
| chr2_169031290_T_A | chr2:169031290 | 5,888 | 2,112 | 3,968 | — |
| chr2_169031176_T_A | chr2:169031176 | 5,824 | 1,664 | 2,240 | — |
| chr2_169031267_C_G | chr2:169031267 | 5,824 | 2,752 | 5,632 | — |
| chr2_169031296_C_A | chr2:169031296 | -5,760 | -3,888 | -9,280 | — |
| chr2_169031178_A_C | chr2:169031178 | 5,760 | 2,112 | 2,624 | — |
| chr2_169031226_T_G | chr2:169031226 | -5,760 | -2,112 | -3,072 | — |
| chr2_169031327_A_G | chr2:169031327 | -5,760 | -1,904 | -4,800 | — |
| chr2_169031329_C_G | chr2:169031329 | -5,760 | -2,336 | -3,904 | — |
| chr2_169031310_G_A | chr2:169031310 | -5,728 | -2,912 | -3,840 | — |
| chr2_169031313_T_A | chr2:169031313 | -5,632 | -2,880 | -6,336 | — |
| chr2_169031323_C_A | chr2:169031323 | -5,600 | -3,136 | -6,080 | — |
| chr2_169031278_A_G | chr2:169031278 | 5,568 | 2,208 | 4,608 | — |
| chr2_169031324_T_G | chr2:169031324 | 5,440 | 3,168 | 4,992 | — |
| chr2_169031279_G_C | chr2:169031279 | -5,376 | -1,952 | -4,032 | — |
| chr2_169031292_A_C | chr2:169031292 | -5,376 | -3,904 | -5,248 | — |
| chr2_169031288_T_G | chr2:169031288 | -5,344 | -3,440 | -8,640 | — |
| chr2_169031294_A_G | chr2:169031294 | -5,280 | -4,544 | -8,960 | — |
| chr2_169031327_A_T | chr2:169031327 | -5,280 | -1,888 | -5,888 | — |
| chr2_169031293_C_A | chr2:169031293 | -5,248 | -3,680 | -5,888 | — |
| chr2_169031197_T_C | chr2:169031197 | -5,248 | -768 | 1,984 | — |
| chr2_169031305_A_T | chr2:169031305 | -5,248 | -2,592 | -4,992 | — |
| chr2_169031264_A_C | chr2:169031264 | -5,216 | -1,920 | -512 | — |
| chr2_169031289_T_G | chr2:169031289 | -5,120 | -4,000 | -6,208 | — |
| chr2_169031316_C_A | chr2:169031316 | 5,120 | 352 | 1,664 | — |
| chr2_169031311_G_A | chr2:169031311 | -5,056 | -1,760 | -3,584 | — |
| chr2_169031306_C_A | chr2:169031306 | -5,024 | -2,976 | -3,584 | — |
| chr2_169031335_A_C | chr2:169031335 | 4,896 | 2,624 | 4,224 | — |
| chr2_169031332_T_G | chr2:169031332 | -4,864 | -2,976 | -5,120 | — |
| chr2_169031171_A_C | chr2:169031171 | 4,864 | 1,280 | 2,496 | — |
| chr2_169031315_T_A | chr2:169031315 | 4,864 | 2,144 | 2,560 | — |
| chr2_169031337_A_C | chr2:169031337 | 4,864 | 2,080 | 1,408 | — |
| chr2_169031294_A_C | chr2:169031294 | -4,800 | -4,384 | -6,784 | — |
| chr2_169031332_T_A | chr2:169031332 | -4,800 | -3,424 | -5,760 | — |
| chr2_169031179_A_C | chr2:169031179 | 4,800 | 800 | 1,728 | — |
| chr2_169031335_A_T | chr2:169031335 | -4,800 | -2,400 | -4,352 | — |
| chr2_169031295_A_C | chr2:169031295 | -4,736 | -3,200 | -5,760 | — |
| chr2_169031308_T_A | chr2:169031308 | 4,736 | 2,016 | 5,248 | — |
| chr2_169031318_T_C | chr2:169031318 | -4,736 | -2,752 | -2,688 | — |
| chr2_169031311_G_C | chr2:169031311 | -4,704 | -2,192 | -3,840 | — |
| chr2_169031339_A_C | chr2:169031339 | 4,608 | 2,272 | 1,152 | — |
| chr2_169031326_A_G | chr2:169031326 | 4,576 | 1,952 | 2,304 | — |
| chr2_169031222_T_G | chr2:169031222 | -4,544 | -3,264 | -4,992 | — |
| chr2_169031326_A_C | chr2:169031326 | 4,512 | 1,984 | 3,328 | — |
| chr2_169031260_A_C | chr2:169031260 | 4,480 | 1,184 | 2,688 | — |
| chr2_169031227_G_C | chr2:169031227 | -4,416 | -1,632 | -2,560 | — |
| chr2_169031266_T_C | chr2:169031266 | -4,416 | -2,240 | -2,176 | — |
| chr2_169008089_G_T | chr2:169008089 | -4,384 | 512 | 2,496 | — |
| chr2_169031317_A_C | chr2:169031317 | -4,320 | -2,816 | -3,456 | — |
| chr2_169031188_G_T | chr2:169031188 | -4,288 | -1,568 | -4,736 | — |
| chr2_169031172_A_C | chr2:169031172 | 4,288 | 1,184 | 2,432 | — |
| chr2_169031241_G_T | chr2:169031241 | 4,288 | 1,408 | 3,264 | — |
| chr2_169031276_A_T | chr2:169031276 | -4,288 | -2,336 | 896 | — |
| chr2_169031296_C_G | chr2:169031296 | -4,224 | -2,432 | -6,400 | — |
| chr2_169031258_T_C | chr2:169031258 | -4,224 | -1,152 | 128 | — |
| chr2_169031302_C_T | chr2:169031302 | -4,192 | -1,536 | -3,072 | — |
| chr2_169031289_T_C | chr2:169031289 | -4,128 | -3,584 | -6,976 | — |
| chr2_169031304_A_T | chr2:169031304 | -4,128 | -2,128 | -3,072 | — |
| chr2_169031323_C_T | chr2:169031323 | -4,128 | -1,856 | -3,008 | — |
| chr2_169031194_G_T | chr2:169031194 | 4,096 | 1,376 | 896 | — |
| chr2_169031337_A_T | chr2:169031337 | 4,000 | 1,600 | 1,792 | — |
| chr2_169031330_A_G | chr2:169031330 | 3,968 | 1,792 | 1,664 | — |
| chr2_169031299_T_C | chr2:169031299 | -3,904 | -2,048 | -3,968 | — |
| chr2_169031247_G_T | chr2:169031247 | 3,904 | 1,504 | 1,088 | — |
| chr2_169031301_T_C | chr2:169031301 | 3,904 | 2,208 | 3,200 | — |
| chr2_169031307_C_T | chr2:169031307 | -3,872 | -2,208 | -4,672 | — |
| chr2_169031245_A_C | chr2:169031245 | 3,840 | 1,504 | 1,984 | — |
| chr2_169031267_C_A | chr2:169031267 | 3,840 | 1,056 | 2,688 | — |
| chr2_169008119_T_A | chr2:169008119 | 3,808 | 800 | -128 | — |
| chr2_169031311_G_T | chr2:169031311 | -3,808 | -1,392 | -3,136 | — |
| chr2_169031216_G_T | chr2:169031216 | 3,776 | 1,440 | 2,368 | — |
| chr2_169031298_T_C | chr2:169031298 | -3,744 | -1,760 | -1,280 | — |
| chr2_169031307_C_A | chr2:169031307 | -3,712 | -1,952 | -3,904 | — |
| chr2_169031194_G_A | chr2:169031194 | 3,712 | 1,280 | -64 | — |
| chr2_169031231_A_C | chr2:169031231 | -3,712 | -1,088 | -896 | — |
| chr2_169031259_A_G | chr2:169031259 | -3,712 | -1,792 | -1,728 | — |
| chr2_169031330_A_C | chr2:169031330 | 3,680 | 2,656 | 3,712 | — |
| chr2_169031186_G_C | chr2:169031186 | 3,648 | 896 | 1,408 | — |
| chr2_169031298_T_A | chr2:169031298 | -3,648 | -2,048 | -2,432 | — |
| chr2_169031325_A_G | chr2:169031325 | 3,616 | 1,856 | 2,432 | — |
| chr2_169031227_G_T | chr2:169031227 | -3,584 | -896 | -2,176 | — |
| chr2_169031235_G_T | chr2:169031235 | 3,584 | 1,312 | 2,048 | — |
| chr2_169031241_G_C | chr2:169031241 | 3,584 | 1,920 | 3,008 | — |
| chr2_169031252_A_C | chr2:169031252 | -3,584 | -1,824 | -1,792 | — |
| chr2_169031278_A_C | chr2:169031278 | -3,584 | -1,504 | -384 | — |
| chr2_169031263_G_C | chr2:169031263 | 3,520 | 1,792 | 4,224 | — |
| chr2_169031173_G_A | chr2:169031173 | 3,520 | 1,632 | 128 | — |
| chr2_169031227_G_A | chr2:169031227 | -3,520 | -1,184 | -1,728 | — |
| chr2_169031244_G_A | chr2:169031244 | 3,520 | 1,120 | 1,792 | — |
| chr2_169031244_G_C | chr2:169031244 | 3,520 | 1,344 | 2,560 | — |
| chr2_169031176_T_G | chr2:169031176 | 3,456 | 1,056 | 2,048 | — |
| chr2_169031180_A_T | chr2:169031180 | -3,456 | -1,440 | -1,792 | — |
| chr2_169031287_G_A | chr2:169031287 | 3,456 | 2,464 | 3,456 | — |
| chr2_169008140_T_G | chr2:169008140 | -3,392 | 64 | -96 | — |
| chr2_169031239_T_C | chr2:169031239 | 3,392 | 1,568 | 1,344 | — |
| chr2_169031299_T_G | chr2:169031299 | 3,392 | 288 | 1,536 | — |
| chr2_169031313_T_G | chr2:169031313 | -3,328 | -2,240 | -4,736 | — |
| chr2_169031263_G_T | chr2:169031263 | 3,328 | 1,984 | 3,584 | — |
| chr2_169008089_G_A | chr2:169008089 | -3,328 | 224 | 1,024 | — |
| chr2_169031318_T_G | chr2:169031318 | -3,296 | -1,728 | -2,688 | — |
| chr2_169031232_T_G | chr2:169031232 | -3,264 | -1,344 | -4,032 | — |
| chr2_169031284_A_G | chr2:169031284 | -3,264 | -1,280 | -3,712 | — |
| chr2_169031174_A_C | chr2:169031174 | 3,264 | 672 | 2,048 | — |
| chr2_169031283_A_T | chr2:169031283 | -3,264 | -1,536 | -2,944 | — |
| chr2_169008120_C_T | chr2:169008120 | 3,232 | 192 | -1,696 | — |
| chr2_169008090_A_T | chr2:169008090 | -3,200 | 128 | 1,792 | — |
| chr2_169031177_T_G | chr2:169031177 | 3,200 | 864 | 2,112 | — |
| chr2_169031200_G_T | chr2:169031200 | 3,200 | 832 | -704 | — |
| chr2_169031220_C_A | chr2:169031220 | -3,200 | -2,080 | -384 | — |
| chr2_169031304_A_G | chr2:169031304 | 3,200 | 2,432 | 2,368 | — |
| chr2_169031167_A_C | chr2:169031167 | 3,136 | 544 | 2,176 | — |
| chr2_169031173_G_C | chr2:169031173 | 3,136 | 768 | 896 | — |
| chr2_169031278_A_T | chr2:169031278 | -3,136 | -1,024 | -1,152 | — |
| chr2_169031303_C_T | chr2:169031303 | 3,104 | 1,536 | 1,920 | — |
| chr2_169031333_G_C | chr2:169031333 | -2,976 | -1,568 | -3,840 | — |
| chr2_169031316_C_T | chr2:169031316 | -2,912 | -3,232 | -4,992 | — |
| chr2_169031251_G_T | chr2:169031251 | -2,752 | -1,440 | -3,264 | — |
| chr2_169031307_C_G | chr2:169031307 | -2,656 | -1,056 | -4,096 | — |
| chr2_169008129_G_C | chr2:169008129 | 2,240 | -576 | -4,256 | — |
| chr2_169031314_T_A | chr2:169031314 | -2,144 | -3,520 | -6,336 | — |
| chr2_169031320_A_G | chr2:169031320 | -1,824 | -1,536 | -3,136 | — |
| chr2_169031293_C_T | chr2:169031293 | -1,664 | -1,376 | -3,456 | — |
| chr2_169031220_C_T | chr2:169031220 | 1,472 | 128 | 3,200 | — |
| chr2_169031287_G_T | chr2:169031287 | -1,344 | -1,376 | -4,352 | — |
| chr2_169031295_A_G | chr2:169031295 | -1,312 | -2,048 | -4,608 | — |
| chr2_169031280_T_A | chr2:169031280 | -1,280 | -1,504 | -3,712 | — |
| chr2_169031236_A_C | chr2:169031236 | 448 | 576 | 3,200 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.