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Bulk and sharded downloads of the variant atlas and the causal chain layers. The variant effect predictions are AlphaGenome Output, used under and subject to the AlphaGenome Output Terms of Use (non-commercial use only). AetherXeno's own annotation and curation layers are released under CC-BY-NC and the code under MIT.
Terms of use. By downloading or using these predictions you agree to the AlphaGenome Output Terms of Use. AetherXeno fine-tunes AlphaGenome per receptor on primary human hepatocyte ChIP-seq and derives the variant effect scores from its output; the predictions are for non-commercial research, not clinical use.
Whole database files
| Dataset | Format | Contents | Endpoint |
|---|---|---|---|
| Variant atlas | JSON / TSV / Parquet | 17,267,831 scored variants × 3 receptors | /api/v1/stats |
| CAMIP Tier 1 causal chains | TSV | 29 gene and receptor causal chains, pharmacist reviewed | bulk |
| CAMIP Tier 2 reference panel | TSV | 25 literature confirmed genes with no atlas binding evidence | bulk |
| Curated non-coding PGx evidence | TSV | 24 curated PGx evidence rows | bulk |
Evidence cross-annotation sets
The four Evidence tables in full: every atlas variant that overlaps each database, with its predicted receptor effects (raw and normalized). CSV, comma delimited.
| Dataset | Variants | Fields | File |
|---|---|---|---|
| ClinVar cross-annotation | 28,227 | significance, condition, receptor effects | evidence_clinvar.csv |
| GTEx liver eQTL | 1,881 | eGene, slope, p value, receptor effects | evidence_gtex.csv |
| GWAS Catalog | 856 | trait, receptor effects | evidence_gwas.csv |
| JASPAR/FIMO motif | 33,531 | motif, receptor element, receptor effects | evidence_motif.csv |
Receptor effects are the raw center bin Δ (ALT minus REF) and the normalized [−1, 1] value for PXR, FXR and AhR. The motif set is RXRA, NR1I2, HNF4A and FOXA1 (FDR significant in the peaks).
Sharded downloads
By chromosome and by receptor at /download/{receptor}/chr{N}.parquet for large scale use.
Permanent archive on Zenodo
The full 17,267,831 variant atlas, spanning in silico saturation and observed variants, plus the annotation layers are deposited on Zenodo with a citable DOI:
aetherxeno_combined.parquet for the full 17.27M atlas, variant_xref.parquet with eQTL, ClinVar, GWAS, motif and phyloP cross annotations, the tier tables, QC report and data dictionary.
Interactive query on this site serves the observed in peak layer from Supabase, while bulk users download the complete atlas from Zenodo. Cite the DOI in Data Availability.