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Terms of use. The variant effect predictions are AlphaGenome Output, used under and subject to the AlphaGenome Output Terms of Use; by downloading or using them you agree to those terms and to non-commercial research use only, not clinical use. AetherXeno finetunes AlphaGenome per receptor on primary human hepatocyte ChIP-seq and derives the variant effect scores from its output. AetherXeno's own annotation and curation layers are released under CC-BY-NC and the code under MIT.
Whole database files
| Dataset | Format | Contents | Endpoint |
|---|---|---|---|
| Variant atlas | JSON / TSV / Parquet | 17,267,831 scored variants × 3 receptors | /api/v1/stats |
| CAMIP Tier 1 causal chains | TSV | 10 pharmacist-reviewed receptor–element–pharmacogene chains anchored to measured PXR/FXR/AhR peaks | bulk |
| Non-coding PGx evidence | TSV | 0 pharmacist-reviewed PGx evidence rows | bulk |
Evidence cross-annotation sets
The four Evidence tables in full: every atlas variant that overlaps each database, with its predicted receptor effects (raw and p99-scaled). CSV, comma delimited.
| Dataset | Variants | Fields | File |
|---|---|---|---|
| ClinVar cross-annotation | 28,227 | significance, condition, receptor effects | evidence_clinvar.csv |
| GTEx liver eQTL | 1,881 | eGene, slope, p value, receptor effects | evidence_gtex.csv |
| GWAS Catalog | 856 | trait, receptor effects | evidence_gwas.csv |
| JASPAR/FIMO motif | 36,528 | motif, receptor element, receptor effects | evidence_motif.csv |
Receptor effects are the raw central five-bin Δ (ALT minus REF; 640 bp) and the p99-scaled [−1, 1] value for PXR, FXR and AhR. Motif hits were retained by FIMO at nominal P < 1 × 10−5.
Sharded downloads
By chromosome and by receptor at /download/{receptor}/chr{N}.parquet for large scale use.
Permanent archive on Zenodo
The full 17,267,831 variant atlas, spanning in silico saturation and observed variants, plus the annotation layers are deposited on Zenodo with a citable DOI:
aetherxeno_combined_globalnorm.parquet for the full 17.27M atlas, variant_xref_globalnorm.parquet with eQTL, ClinVar, GWAS, motif and phyloP cross annotations, the tier tables, QC report and data dictionary.
Interactive query on this site serves the full scored atlas from Supabase; bulk users can download the complete, versioned files from Zenodo. Cite the DOI in Data Availability.