Home / Gene
ALDH3A1
receptor: AhRTier 1
CAMIP causal chains
AhR
Reduced AhR-mediated induction of ALDH3A1 would lower ALDH3A1-mediated oxidation of aldophosphamide; increased retention of the active intermediate may sensitise tumour cells to cyclophosphamide.
Affected substrate drugs (PharmGKB): cyclophosphamide; doxorubicin; fluorouracil
Scored variants near ALDH3A1
chr17:19,637,984..19,848,298, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr17_19648971_C_G | chr17:19648971 | 49,152 | 608 | 5,632 | — |
| chr17_19648978_C_G | chr17:19648978 | 45,696 | 14,592 | 12,288 | — |
| chr17_19648930_C_A | chr17:19648930 | 39,424 | 4,064 | 7,424 | — |
| chr17_19649058_C_G | chr17:19649058 | 38,400 | 1,792 | 6,784 | 4.6e-5 |
| chr17_19648985_T_C | chr17:19648985 | -37,376 | -9,920 | -13,056 | — |
| chr17_19648985_T_A | chr17:19648985 | -36,736 | -9,984 | -14,592 | — |
| chr17_19648985_T_G | chr17:19648985 | -35,968 | -9,696 | -11,008 | — |
| chr17_19648862_C_G | chr17:19648862 | -34,048 | -6,080 | -3,840 | — |
| chr17_19648984_G_A | chr17:19648984 | -33,920 | -8,448 | -10,752 | — |
| chr17_19648981_G_A | chr17:19648981 | 33,664 | 11,488 | 6,912 | — |
| chr17_19648977_G_A | chr17:19648977 | -33,536 | -6,976 | -12,544 | — |
| chr17_19648984_G_T | chr17:19648984 | -33,408 | -7,744 | -9,472 | — |
| chr17_19648981_G_C | chr17:19648981 | -33,280 | -8,032 | -11,264 | — |
| chr17_19648804_G_A | chr17:19648804 | 32,000 | 6,048 | 6,144 | — |
| chr17_19648860_G_C | chr17:19648860 | 32,000 | 2,496 | 7,936 | — |
| chr17_19648977_G_T | chr17:19648977 | -31,232 | -8,160 | -10,240 | — |
| chr17_19648980_C_G | chr17:19648980 | -30,848 | -6,656 | -8,704 | — |
| chr17_19648799_A_G | chr17:19648799 | -30,464 | -6,048 | -2,048 | — |
| chr17_19649017_C_A | chr17:19649017 | 30,464 | 9,664 | 11,648 | — |
| chr17_19648982_A_G | chr17:19648982 | -29,824 | -7,264 | -6,912 | — |
| chr17_19648931_C_A | chr17:19648931 | 29,568 | 2,336 | 9,472 | — |
| chr17_19648792_G_C | chr17:19648792 | -29,440 | -4,096 | -3,328 | — |
| chr17_19648982_A_C | chr17:19648982 | -28,928 | -7,136 | -5,888 | — |
| chr17_19648980_C_A | chr17:19648980 | -28,544 | -6,304 | -10,240 | — |
| chr17_19648865_C_G | chr17:19648865 | 28,160 | 192 | 1,792 | — |
| chr17_19648984_G_C | chr17:19648984 | -27,776 | -6,304 | -7,936 | — |
| chr17_19648996_C_A | chr17:19648996 | 27,776 | 8,608 | 7,168 | — |
| chr17_19648820_G_C | chr17:19648820 | -27,264 | -2,176 | -1,280 | — |
| chr17_19649017_C_G | chr17:19649017 | 27,136 | 9,376 | 7,808 | — |
| chr17_19648982_A_T | chr17:19648982 | -26,496 | -6,464 | -6,656 | — |
| chr17_19648799_A_T | chr17:19648799 | -26,368 | -8,352 | -3,072 | — |
| chr17_19648923_C_A | chr17:19648923 | 26,112 | 5,120 | 6,400 | — |
| chr17_19648983_A_T | chr17:19648983 | -25,472 | -6,784 | -6,144 | — |
| chr17_19648865_C_A | chr17:19648865 | 25,088 | 1,152 | 1,792 | — |
| chr17_19648980_C_T | chr17:19648980 | -24,960 | -5,248 | -7,936 | — |
| chr17_19648977_G_C | chr17:19648977 | -24,448 | -6,912 | -5,632 | — |
| chr17_19648983_A_C | chr17:19648983 | -24,064 | -4,576 | -6,400 | — |
| chr17_19649025_A_T | chr17:19649025 | -24,064 | -7,296 | -2,816 | — |
| chr17_19648946_C_G | chr17:19648946 | 23,936 | 2,528 | 6,912 | — |
| chr17_19648981_G_T | chr17:19648981 | -23,808 | -6,144 | -10,240 | — |
| chr17_19649023_C_T | chr17:19649023 | 23,424 | 7,872 | 5,760 | — |
| chr17_19649028_T_A | chr17:19649028 | -23,424 | -6,560 | -5,632 | — |
| chr17_19648877_G_A | chr17:19648877 | -23,296 | -4,576 | -7,680 | 1.3e-5 |
| chr17_19648877_G_T | chr17:19648877 | -23,296 | -7,200 | -11,520 | — |
| chr17_19648987_C_G | chr17:19648987 | -23,168 | -5,984 | -8,448 | — |
| chr17_19648930_C_T | chr17:19648930 | 22,656 | 1,888 | 3,584 | — |
| chr17_19648987_C_A | chr17:19648987 | -22,272 | -4,576 | -9,472 | — |
| chr17_19648923_C_G | chr17:19648923 | 21,760 | 2,784 | 6,656 | — |
| chr17_19648990_C_G | chr17:19648990 | -21,760 | -4,320 | -10,240 | — |
| chr17_19649056_G_A | chr17:19649056 | -21,760 | -3,424 | -8,960 | — |
| chr17_19648859_A_G | chr17:19648859 | 21,504 | 3,776 | 1,024 | — |
| chr17_19648836_T_C | chr17:19648836 | 21,248 | 5,440 | 4,096 | 4.6e-5 |
| chr17_19649076_G_A | chr17:19649076 | 21,248 | 7,392 | 19,072 | — |
| chr17_19648979_T_C | chr17:19648979 | -21,120 | -4,672 | -6,400 | — |
| chr17_19648877_G_C | chr17:19648877 | -20,608 | -3,840 | -4,352 | — |
| chr17_19649025_A_G | chr17:19649025 | -20,480 | -6,624 | -1,792 | — |
| chr17_19648932_C_T | chr17:19648932 | 20,352 | 1,216 | 4,864 | — |
| chr17_19648843_T_G | chr17:19648843 | -20,224 | -3,136 | -256 | — |
| chr17_19648939_C_A | chr17:19648939 | 20,224 | 4,544 | 5,376 | — |
| chr17_19648930_C_G | chr17:19648930 | 19,840 | 2,272 | 5,632 | — |
| chr17_19649023_C_G | chr17:19649023 | -19,712 | -4,800 | -5,632 | — |
| chr17_19648983_A_G | chr17:19648983 | -19,584 | -5,952 | -4,352 | — |
| chr17_19648861_A_C | chr17:19648861 | 19,456 | 3,200 | 4,096 | — |
| chr17_19649024_G_C | chr17:19649024 | -19,456 | -5,568 | -3,456 | — |
| chr17_19648792_G_T | chr17:19648792 | -19,200 | -2,336 | -3,584 | — |
| chr17_19648865_C_T | chr17:19648865 | 19,200 | 704 | -1,536 | 6.6e-6 |
| chr17_19648878_G_A | chr17:19648878 | -19,200 | -4,064 | -6,912 | — |
| chr17_19648925_C_T | chr17:19648925 | 19,200 | 2,752 | 3,328 | — |
| chr17_19648979_T_G | chr17:19648979 | -19,072 | -3,776 | -4,608 | 6.6e-6 |
| chr17_19649024_G_T | chr17:19649024 | -19,072 | -5,888 | -6,784 | — |
| chr17_19648988_G_A | chr17:19648988 | 18,944 | 4,032 | 4,096 | — |
| chr17_19648987_C_T | chr17:19648987 | -18,816 | -4,704 | -8,960 | 6.6e-6 |
| chr17_19648991_G_C | chr17:19648991 | -18,560 | -3,520 | -6,912 | — |
| chr17_19649023_C_A | chr17:19649023 | -18,432 | -4,224 | -6,784 | — |
| chr17_19648942_G_T | chr17:19648942 | 18,304 | 2,720 | 3,840 | — |
| chr17_19648921_C_A | chr17:19648921 | -18,176 | -6,304 | -6,144 | — |
| chr17_19648785_C_T | chr17:19648785 | -18,048 | -5,504 | -5,120 | — |
| chr17_19648881_G_A | chr17:19648881 | -18,048 | -3,840 | -4,608 | — |
| chr17_19648988_G_T | chr17:19648988 | -17,792 | -4,928 | -7,680 | — |
| chr17_19648839_T_G | chr17:19648839 | -17,664 | -2,240 | 768 | — |
| chr17_19648863_A_C | chr17:19648863 | -17,664 | -2,496 | 0 | — |
| chr17_19648878_G_C | chr17:19648878 | -17,664 | -3,328 | -7,168 | — |
| chr17_19648784_A_T | chr17:19648784 | -17,536 | -1,568 | -4,608 | — |
| chr17_19648876_A_T | chr17:19648876 | -17,536 | -3,456 | -4,352 | — |
| chr17_19649027_C_T | chr17:19649027 | -17,536 | -4,928 | -5,632 | — |
| chr17_19648880_G_T | chr17:19648880 | -17,280 | -3,264 | -4,608 | — |
| chr17_19648920_C_A | chr17:19648920 | -17,024 | -3,552 | -2,816 | — |
| chr17_19648777_C_A | chr17:19648777 | -16,896 | -1,888 | 0 | — |
| chr17_19648904_A_C | chr17:19648904 | -16,896 | -4,032 | -3,584 | — |
| chr17_19648908_G_C | chr17:19648908 | -16,896 | -5,632 | -3,840 | — |
| chr17_19648988_G_C | chr17:19648988 | -16,768 | -5,440 | -5,888 | 1.3e-5 |
| chr17_19649085_G_T | chr17:19649085 | 16,768 | -2,144 | 3,328 | — |
| chr17_19648829_G_C | chr17:19648829 | 16,640 | 4,224 | 3,584 | — |
| chr17_19648853_C_G | chr17:19648853 | 16,640 | 3,392 | 4,608 | — |
| chr17_19648880_G_C | chr17:19648880 | -16,640 | -3,424 | -3,584 | — |
| chr17_19648986_C_G | chr17:19648986 | -16,640 | -3,616 | -3,840 | — |
| chr17_19648878_G_T | chr17:19648878 | -16,384 | -2,688 | -6,912 | — |
| chr17_19648919_G_T | chr17:19648919 | 16,128 | 2,240 | 0 | — |
| chr17_19648925_C_G | chr17:19648925 | 16,000 | 1,152 | 3,072 | — |
| chr17_19648880_G_A | chr17:19648880 | -15,872 | -3,232 | -5,632 | — |
| chr17_19648892_G_T | chr17:19648892 | -15,744 | -4,128 | -9,728 | — |
| chr17_19649024_G_A | chr17:19649024 | -15,744 | -4,576 | -6,656 | — |
| chr17_19649028_T_G | chr17:19649028 | -15,744 | -5,376 | -2,432 | — |
| chr17_19648862_C_T | chr17:19648862 | -15,616 | -2,880 | -2,048 | — |
| chr17_19648931_C_G | chr17:19648931 | 15,616 | 1,120 | 5,120 | — |
| chr17_19648793_G_A | chr17:19648793 | -15,488 | -1,664 | 0 | 6.6e-6 |
| chr17_19648794_C_A | chr17:19648794 | -15,488 | -736 | -5,632 | — |
| chr17_19648881_G_T | chr17:19648881 | -15,488 | -3,040 | -3,072 | — |
| chr17_19649022_G_C | chr17:19649022 | -15,488 | -3,520 | -6,656 | — |
| chr17_19649028_T_C | chr17:19649028 | -15,488 | -2,176 | -2,816 | — |
| chr17_19649026_C_T | chr17:19649026 | -15,360 | -5,056 | -3,840 | — |
| chr17_19648986_C_A | chr17:19648986 | -15,232 | -3,296 | -6,656 | — |
| chr17_19648791_G_C | chr17:19648791 | -15,104 | -3,392 | -4,352 | 6.6e-6 |
| chr17_19648795_G_A | chr17:19648795 | -15,104 | -832 | 768 | 6.6e-6 |
| chr17_19648798_G_A | chr17:19648798 | 15,104 | 8,192 | -1,024 | — |
| chr17_19648989_G_C | chr17:19648989 | 15,104 | 4,096 | 3,072 | — |
| chr17_19649026_C_G | chr17:19649026 | -15,104 | -5,088 | -384 | — |
| chr17_19648904_A_T | chr17:19648904 | -14,976 | -5,280 | -4,352 | — |
| chr17_19648979_T_A | chr17:19648979 | -14,976 | -2,752 | -1,536 | — |
| chr17_19648995_C_G | chr17:19648995 | 14,976 | 4,128 | 1,792 | — |
| chr17_19648928_T_C | chr17:19648928 | -14,848 | -5,088 | -21,760 | — |
| chr17_19648792_G_A | chr17:19648792 | -14,848 | -1,984 | -7,680 | — |
| chr17_19648788_A_C | chr17:19648788 | -14,720 | -2,912 | -2,048 | — |
| chr17_19649011_T_A | chr17:19649011 | 14,720 | 4,928 | 1,792 | — |
| chr17_19648920_C_T | chr17:19648920 | -14,592 | -3,008 | -512 | — |
| chr17_19648924_C_T | chr17:19648924 | 14,592 | 1,952 | 2,816 | — |
| chr17_19648925_C_A | chr17:19648925 | 14,592 | 2,016 | 2,560 | — |
| chr17_19649030_T_C | chr17:19649030 | -14,592 | -3,104 | -2,816 | — |
| chr17_19649027_C_G | chr17:19649027 | -14,464 | -4,736 | 256 | — |
| chr17_19649030_T_A | chr17:19649030 | -14,464 | -2,368 | -3,072 | — |
| chr17_19648926_A_G | chr17:19648926 | 14,336 | 1,152 | 2,304 | — |
| chr17_19648936_G_C | chr17:19648936 | 14,336 | 2,656 | -3,840 | — |
| chr17_19648976_A_T | chr17:19648976 | -14,336 | -3,360 | -4,864 | — |
| chr17_19648986_C_T | chr17:19648986 | -14,336 | -1,472 | -6,144 | — |
| chr17_19648907_T_G | chr17:19648907 | -14,080 | -4,480 | -2,304 | — |
| chr17_19648945_C_G | chr17:19648945 | 14,080 | 3,008 | 2,560 | — |
| chr17_19649021_C_A | chr17:19649021 | 14,080 | -640 | 2,176 | — |
| chr17_19649026_C_A | chr17:19649026 | -14,080 | -4,256 | -4,096 | — |
| chr17_19649065_A_G | chr17:19649065 | 13,952 | 4,416 | 4,096 | — |
| chr17_19648777_C_T | chr17:19648777 | -13,824 | -736 | 0 | — |
| chr17_19648896_A_T | chr17:19648896 | 13,824 | 2,816 | 3,840 | — |
| chr17_19648960_C_A | chr17:19648960 | -13,824 | -2,464 | -2,816 | — |
| chr17_19649049_G_C | chr17:19649049 | -13,824 | -736 | -6,400 | — |
| chr17_19649054_A_G | chr17:19649054 | -13,824 | -1,344 | -6,528 | — |
| chr17_19648899_C_G | chr17:19648899 | -13,696 | -1,376 | -7,680 | — |
| chr17_19649031_G_T | chr17:19649031 | -13,696 | -2,848 | -3,584 | — |
| chr17_19648817_C_G | chr17:19648817 | -13,568 | -2,944 | 2,048 | 6.6e-6 |
| chr17_19648843_T_A | chr17:19648843 | -13,568 | -1,472 | 1,792 | — |
| chr17_19648845_T_G | chr17:19648845 | -13,568 | -1,728 | -1,024 | — |
| chr17_19648847_G_C | chr17:19648847 | 13,568 | 1,920 | 1,280 | — |
| chr17_19648868_C_A | chr17:19648868 | -13,568 | -3,616 | -2,816 | 6.6e-6 |
| chr17_19648938_C_A | chr17:19648938 | 13,568 | 2,176 | 2,816 | — |
| chr17_19649068_A_G | chr17:19649068 | 13,568 | 4,512 | 7,936 | — |
| chr17_19648956_T_A | chr17:19648956 | 13,440 | 3,360 | 6,656 | — |
| chr17_19648828_C_T | chr17:19648828 | -13,312 | -1,984 | -4,864 | — |
| chr17_19648901_T_G | chr17:19648901 | -13,184 | -2,208 | -4,864 | — |
| chr17_19648798_G_C | chr17:19648798 | 13,056 | 1,376 | -2,048 | — |
| chr17_19648834_A_C | chr17:19648834 | 13,056 | 1,344 | 256 | — |
| chr17_19648848_G_T | chr17:19648848 | 13,056 | 1,856 | -3,072 | 1.3e-5 |
| chr17_19648860_G_A | chr17:19648860 | 13,056 | 1,152 | 512 | — |
| chr17_19648884_G_C | chr17:19648884 | 13,056 | 1,696 | 6,656 | — |
| chr17_19648907_T_C | chr17:19648907 | -13,056 | -4,704 | -2,560 | 6.6e-6 |
| chr17_19649022_G_A | chr17:19649022 | 13,056 | 4,224 | 2,944 | — |
| chr17_19648883_G_A | chr17:19648883 | -12,928 | -1,536 | -4,352 | — |
| chr17_19649030_T_G | chr17:19649030 | -12,928 | -2,368 | -1,024 | — |
| chr17_19648784_A_C | chr17:19648784 | 12,800 | 480 | 5,120 | — |
| chr17_19648804_G_C | chr17:19648804 | -12,800 | -3,296 | -2,560 | — |
| chr17_19648860_G_T | chr17:19648860 | 12,800 | 2,624 | 5,120 | — |
| chr17_19648901_T_C | chr17:19648901 | -12,800 | -2,720 | -4,608 | — |
| chr17_19649031_G_C | chr17:19649031 | -12,800 | -2,848 | -2,176 | — |
| chr17_19648774_T_G | chr17:19648774 | -12,672 | -640 | -2,304 | — |
| chr17_19648923_C_T | chr17:19648923 | 12,672 | 2,176 | 2,048 | 1.3e-5 |
| chr17_19649079_G_T | chr17:19649079 | 12,672 | 352 | 5,120 | — |
| chr17_19648803_C_G | chr17:19648803 | -12,544 | -5,056 | 2,816 | — |
| chr17_19648847_G_T | chr17:19648847 | 12,544 | 2,112 | 0 | — |
| chr17_19648927_C_A | chr17:19648927 | 12,544 | 2,432 | 4,096 | — |
| chr17_19648908_G_A | chr17:19648908 | -12,416 | -3,936 | -2,304 | — |
| chr17_19648997_G_C | chr17:19648997 | -12,416 | -3,936 | -4,992 | — |
| chr17_19648779_G_C | chr17:19648779 | 12,288 | 2,272 | 4,352 | — |
| chr17_19648780_T_G | chr17:19648780 | -12,288 | -224 | 0 | 6.6e-6 |
| chr17_19648832_T_G | chr17:19648832 | -12,288 | -2,496 | 1,024 | — |
| chr17_19648908_G_T | chr17:19648908 | -12,288 | -4,192 | -5,120 | — |
| chr17_19648962_G_T | chr17:19648962 | 12,288 | 2,816 | 3,584 | — |
| chr17_19648897_G_T | chr17:19648897 | -12,160 | -2,336 | -6,400 | — |
| chr17_19648943_G_T | chr17:19648943 | 12,160 | 416 | 3,072 | — |
| chr17_19648809_T_G | chr17:19648809 | -12,032 | -2,880 | 3,072 | — |
| chr17_19648895_G_A | chr17:19648895 | -12,032 | -2,560 | -3,840 | — |
| chr17_19648905_C_A | chr17:19648905 | -12,032 | -5,280 | -6,656 | — |
| chr17_19648773_C_G | chr17:19648773 | -11,904 | -1,408 | -256 | — |
| chr17_19648881_G_C | chr17:19648881 | -11,904 | -2,784 | -2,048 | 6.6e-6 |
| chr17_19648892_G_A | chr17:19648892 | -11,904 | -2,144 | -7,168 | — |
| chr17_19649015_G_C | chr17:19649015 | 11,904 | 3,264 | 4,352 | — |
| chr17_19648797_G_A | chr17:19648797 | 11,776 | 5,760 | 1,536 | — |
| chr17_19648833_G_C | chr17:19648833 | 11,776 | 1,920 | 4,096 | — |
| chr17_19648866_C_G | chr17:19648866 | 11,776 | -1,120 | 2,560 | — |
| chr17_19648943_G_C | chr17:19648943 | 11,776 | 2,080 | 3,840 | — |
| chr17_19648963_G_C | chr17:19648963 | 11,776 | 2,816 | 1,792 | — |
| chr17_19648922_T_C | chr17:19648922 | -9,344 | -2,080 | -17,920 | — |
| chr17_19648782_G_T | chr17:19648782 | 5,376 | 2,720 | 25,600 | — |
| chr17_19648926_A_C | chr17:19648926 | -2,304 | -1,344 | -13,056 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.