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ALDH3A1
receptor: AhRTier 1
CAMIP causal chains
AhR
Reduced AhR-mediated induction of ALDH3A1 would lower ALDH3A1-mediated oxidation of aldophosphamide; increased retention of the active intermediate may sensitise tumour cells to cyclophosphamide.
Drug context: cyclophosphamide; doxorubicin; fluorouracil
Scored variants near ALDH3A1
chr17:19,637,984..19,848,298, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr17_19648971_C_G | chr17:19648971 | 1.000 | 0.048 | 0.259 | — |
| chr17_19648978_C_G | chr17:19648978 | 1.000 | 1.000 | 0.565 | — |
| chr17_19648930_C_A | chr17:19648930 | 1.000 | 0.322 | 0.341 | — |
| chr17_19649058_C_G | chr17:19649058 | 0.998 | 0.142 | 0.312 | 0.0046% |
| chr17_19648985_T_C | chr17:19648985 | -0.972 | -0.787 | -0.600 | — |
| chr17_19648985_T_A | chr17:19648985 | -0.955 | -0.792 | -0.671 | — |
| chr17_19648985_T_G | chr17:19648985 | -0.935 | -0.769 | -0.506 | — |
| chr17_19648862_C_G | chr17:19648862 | -0.885 | -0.482 | -0.176 | — |
| chr17_19648984_G_A | chr17:19648984 | -0.882 | -0.670 | -0.494 | — |
| chr17_19648981_G_A | chr17:19648981 | 0.875 | 0.911 | 0.318 | — |
| chr17_19648977_G_A | chr17:19648977 | -0.872 | -0.553 | -0.576 | — |
| chr17_19648984_G_T | chr17:19648984 | -0.869 | -0.614 | -0.435 | — |
| chr17_19648981_G_C | chr17:19648981 | -0.865 | -0.637 | -0.518 | — |
| chr17_19648804_G_A | chr17:19648804 | 0.832 | 0.480 | 0.282 | — |
| chr17_19648860_G_C | chr17:19648860 | 0.832 | 0.198 | 0.365 | — |
| chr17_19648977_G_T | chr17:19648977 | -0.812 | -0.647 | -0.471 | — |
| chr17_19648980_C_G | chr17:19648980 | -0.802 | -0.528 | -0.400 | — |
| chr17_19648799_A_G | chr17:19648799 | -0.792 | -0.480 | -0.094 | — |
| chr17_19649017_C_A | chr17:19649017 | 0.792 | 0.766 | 0.535 | — |
| chr17_19648982_A_G | chr17:19648982 | -0.775 | -0.576 | -0.318 | — |
| chr17_19648931_C_A | chr17:19648931 | 0.769 | 0.185 | 0.435 | — |
| chr17_19648792_G_C | chr17:19648792 | -0.765 | -0.325 | -0.153 | — |
| chr17_19648982_A_C | chr17:19648982 | -0.752 | -0.566 | -0.271 | — |
| chr17_19648980_C_A | chr17:19648980 | -0.742 | -0.500 | -0.471 | — |
| chr17_19648865_C_G | chr17:19648865 | 0.732 | 0.015 | 0.082 | — |
| chr17_19648984_G_C | chr17:19648984 | -0.722 | -0.500 | -0.365 | — |
| chr17_19648996_C_A | chr17:19648996 | 0.722 | 0.683 | 0.329 | — |
| chr17_19648820_G_C | chr17:19648820 | -0.709 | -0.173 | -0.059 | — |
| chr17_19649017_C_G | chr17:19649017 | 0.705 | 0.744 | 0.359 | — |
| chr17_19648982_A_T | chr17:19648982 | -0.689 | -0.513 | -0.306 | — |
| chr17_19648799_A_T | chr17:19648799 | -0.686 | -0.662 | -0.141 | — |
| chr17_19648923_C_A | chr17:19648923 | 0.679 | 0.406 | 0.294 | — |
| chr17_19648782_G_T | chr17:19648782 | 0.140 | 0.216 | 1.000 | — |
| chr17_19648983_A_T | chr17:19648983 | -0.662 | -0.538 | -0.282 | — |
| chr17_19648865_C_A | chr17:19648865 | 0.652 | 0.091 | 0.082 | — |
| chr17_19648980_C_T | chr17:19648980 | -0.649 | -0.416 | -0.365 | — |
| chr17_19648977_G_C | chr17:19648977 | -0.636 | -0.548 | -0.259 | — |
| chr17_19648983_A_C | chr17:19648983 | -0.626 | -0.363 | -0.294 | — |
| chr17_19649025_A_T | chr17:19649025 | -0.626 | -0.579 | -0.129 | — |
| chr17_19648946_C_G | chr17:19648946 | 0.622 | 0.201 | 0.318 | — |
| chr17_19648981_G_T | chr17:19648981 | -0.619 | -0.487 | -0.471 | — |
| chr17_19649023_C_T | chr17:19649023 | 0.609 | 0.624 | 0.265 | — |
| chr17_19649028_T_A | chr17:19649028 | -0.609 | -0.520 | -0.259 | — |
| chr17_19648877_G_A | chr17:19648877 | -0.606 | -0.363 | -0.353 | 0.0013% |
| chr17_19648877_G_T | chr17:19648877 | -0.606 | -0.571 | -0.529 | — |
| chr17_19648987_C_G | chr17:19648987 | -0.602 | -0.475 | -0.388 | — |
| chr17_19648930_C_T | chr17:19648930 | 0.589 | 0.150 | 0.165 | — |
| chr17_19648987_C_A | chr17:19648987 | -0.579 | -0.363 | -0.435 | — |
| chr17_19648923_C_G | chr17:19648923 | 0.566 | 0.221 | 0.306 | — |
| chr17_19648928_T_C | chr17:19648928 | -0.386 | -0.404 | -1.000 | — |
| chr17_19648990_C_G | chr17:19648990 | -0.566 | -0.343 | -0.471 | — |
| chr17_19649056_G_A | chr17:19649056 | -0.566 | -0.272 | -0.412 | — |
| chr17_19648859_A_G | chr17:19648859 | 0.559 | 0.299 | 0.047 | — |
| chr17_19648836_T_C | chr17:19648836 | 0.552 | 0.431 | 0.188 | 0.0046% |
| chr17_19649076_G_A | chr17:19649076 | 0.552 | 0.586 | 0.876 | — |
| chr17_19648979_T_C | chr17:19648979 | -0.549 | -0.371 | -0.294 | — |
| chr17_19648877_G_C | chr17:19648877 | -0.536 | -0.305 | -0.200 | — |
| chr17_19649025_A_G | chr17:19649025 | -0.532 | -0.525 | -0.082 | — |
| chr17_19648932_C_T | chr17:19648932 | 0.529 | 0.096 | 0.224 | — |
| chr17_19648843_T_G | chr17:19648843 | -0.526 | -0.249 | -0.012 | — |
| chr17_19648939_C_A | chr17:19648939 | 0.526 | 0.360 | 0.247 | — |
| chr17_19648930_C_G | chr17:19648930 | 0.516 | 0.180 | 0.259 | — |
| chr17_19649023_C_G | chr17:19649023 | -0.512 | -0.381 | -0.259 | — |
| chr17_19648983_A_G | chr17:19648983 | -0.509 | -0.472 | -0.200 | — |
| chr17_19648861_A_C | chr17:19648861 | 0.506 | 0.254 | 0.188 | — |
| chr17_19649024_G_C | chr17:19649024 | -0.506 | -0.442 | -0.159 | — |
| chr17_19648792_G_T | chr17:19648792 | -0.499 | -0.185 | -0.165 | — |
| chr17_19648865_C_T | chr17:19648865 | 0.499 | 0.056 | -0.071 | <0.001% |
| chr17_19648878_G_A | chr17:19648878 | -0.499 | -0.322 | -0.318 | — |
| chr17_19648925_C_T | chr17:19648925 | 0.499 | 0.218 | 0.153 | — |
| chr17_19648979_T_G | chr17:19648979 | -0.496 | -0.299 | -0.212 | <0.001% |
| chr17_19649024_G_T | chr17:19649024 | -0.496 | -0.467 | -0.312 | — |
| chr17_19648988_G_A | chr17:19648988 | 0.493 | 0.320 | 0.188 | — |
| chr17_19648987_C_T | chr17:19648987 | -0.489 | -0.373 | -0.412 | <0.001% |
| chr17_19648991_G_C | chr17:19648991 | -0.483 | -0.279 | -0.318 | — |
| chr17_19649023_C_A | chr17:19649023 | -0.479 | -0.335 | -0.312 | — |
| chr17_19648942_G_T | chr17:19648942 | 0.476 | 0.216 | 0.176 | — |
| chr17_19648921_C_A | chr17:19648921 | -0.473 | -0.500 | -0.282 | — |
| chr17_19648785_C_T | chr17:19648785 | -0.469 | -0.437 | -0.235 | — |
| chr17_19648881_G_A | chr17:19648881 | -0.469 | -0.305 | -0.212 | — |
| chr17_19648922_T_C | chr17:19648922 | -0.243 | -0.165 | -0.824 | — |
| chr17_19648988_G_T | chr17:19648988 | -0.463 | -0.391 | -0.353 | — |
| chr17_19648839_T_G | chr17:19648839 | -0.459 | -0.178 | 0.035 | — |
| chr17_19648863_A_C | chr17:19648863 | -0.459 | -0.198 | 0.000 | — |
| chr17_19648878_G_C | chr17:19648878 | -0.459 | -0.264 | -0.329 | — |
| chr17_19648784_A_T | chr17:19648784 | -0.456 | -0.124 | -0.212 | — |
| chr17_19648876_A_T | chr17:19648876 | -0.456 | -0.274 | -0.200 | — |
| chr17_19649027_C_T | chr17:19649027 | -0.456 | -0.391 | -0.259 | — |
| chr17_19648880_G_T | chr17:19648880 | -0.449 | -0.259 | -0.212 | — |
| chr17_19648920_C_A | chr17:19648920 | -0.443 | -0.282 | -0.129 | — |
| chr17_19648777_C_A | chr17:19648777 | -0.439 | -0.150 | 0.000 | — |
| chr17_19648904_A_C | chr17:19648904 | -0.439 | -0.320 | -0.165 | — |
| chr17_19648908_G_C | chr17:19648908 | -0.439 | -0.447 | -0.176 | — |
| chr17_19648988_G_C | chr17:19648988 | -0.436 | -0.431 | -0.271 | 0.0013% |
| chr17_19649085_G_T | chr17:19649085 | 0.436 | -0.170 | 0.153 | — |
| chr17_19648829_G_C | chr17:19648829 | 0.433 | 0.335 | 0.165 | — |
| chr17_19648853_C_G | chr17:19648853 | 0.433 | 0.269 | 0.212 | — |
| chr17_19648880_G_C | chr17:19648880 | -0.433 | -0.272 | -0.165 | — |
| chr17_19648986_C_G | chr17:19648986 | -0.433 | -0.287 | -0.176 | — |
| chr17_19648878_G_T | chr17:19648878 | -0.426 | -0.213 | -0.318 | — |
| chr17_19648919_G_T | chr17:19648919 | 0.419 | 0.178 | 0.000 | — |
| chr17_19648925_C_G | chr17:19648925 | 0.416 | 0.091 | 0.141 | — |
| chr17_19648880_G_A | chr17:19648880 | -0.413 | -0.256 | -0.259 | — |
| chr17_19648892_G_T | chr17:19648892 | -0.409 | -0.327 | -0.447 | — |
| chr17_19649024_G_A | chr17:19649024 | -0.409 | -0.363 | -0.306 | — |
| chr17_19649028_T_G | chr17:19649028 | -0.409 | -0.426 | -0.112 | — |
| chr17_19648862_C_T | chr17:19648862 | -0.406 | -0.228 | -0.094 | — |
| chr17_19648931_C_G | chr17:19648931 | 0.406 | 0.089 | 0.235 | — |
| chr17_19648793_G_A | chr17:19648793 | -0.403 | -0.132 | 0.000 | <0.001% |
| chr17_19648794_C_A | chr17:19648794 | -0.403 | -0.058 | -0.259 | — |
| chr17_19648881_G_T | chr17:19648881 | -0.403 | -0.241 | -0.141 | — |
| chr17_19649022_G_C | chr17:19649022 | -0.403 | -0.279 | -0.306 | — |
| chr17_19649028_T_C | chr17:19649028 | -0.403 | -0.173 | -0.129 | — |
| chr17_19649026_C_T | chr17:19649026 | -0.399 | -0.401 | -0.176 | — |
| chr17_19648986_C_A | chr17:19648986 | -0.396 | -0.261 | -0.306 | — |
| chr17_19648791_G_C | chr17:19648791 | -0.393 | -0.269 | -0.200 | <0.001% |
| chr17_19648795_G_A | chr17:19648795 | -0.393 | -0.066 | 0.035 | <0.001% |
| chr17_19648798_G_A | chr17:19648798 | 0.393 | 0.650 | -0.047 | — |
| chr17_19648989_G_C | chr17:19648989 | 0.393 | 0.325 | 0.141 | — |
| chr17_19649026_C_G | chr17:19649026 | -0.393 | -0.404 | -0.018 | — |
| chr17_19648904_A_T | chr17:19648904 | -0.389 | -0.419 | -0.200 | — |
| chr17_19648979_T_A | chr17:19648979 | -0.389 | -0.218 | -0.071 | — |
| chr17_19648995_C_G | chr17:19648995 | 0.389 | 0.327 | 0.082 | — |
| chr17_19648792_G_A | chr17:19648792 | -0.386 | -0.157 | -0.353 | — |
| chr17_19648788_A_C | chr17:19648788 | -0.383 | -0.231 | -0.094 | — |
| chr17_19649011_T_A | chr17:19649011 | 0.383 | 0.391 | 0.082 | — |
| chr17_19648920_C_T | chr17:19648920 | -0.379 | -0.239 | -0.024 | — |
| chr17_19648924_C_T | chr17:19648924 | 0.379 | 0.155 | 0.129 | — |
| chr17_19648925_C_A | chr17:19648925 | 0.379 | 0.160 | 0.118 | — |
| chr17_19649030_T_C | chr17:19649030 | -0.379 | -0.246 | -0.129 | — |
| chr17_19649027_C_G | chr17:19649027 | -0.376 | -0.376 | 0.012 | — |
| chr17_19649030_T_A | chr17:19649030 | -0.376 | -0.188 | -0.141 | — |
| chr17_19648926_A_G | chr17:19648926 | 0.373 | 0.091 | 0.106 | — |
| chr17_19648936_G_C | chr17:19648936 | 0.373 | 0.211 | -0.176 | — |
| chr17_19648976_A_T | chr17:19648976 | -0.373 | -0.266 | -0.224 | — |
| chr17_19648986_C_T | chr17:19648986 | -0.373 | -0.117 | -0.282 | — |
| chr17_19648907_T_G | chr17:19648907 | -0.366 | -0.355 | -0.106 | — |
| chr17_19648945_C_G | chr17:19648945 | 0.366 | 0.239 | 0.118 | — |
| chr17_19649021_C_A | chr17:19649021 | 0.366 | -0.051 | 0.100 | — |
| chr17_19649026_C_A | chr17:19649026 | -0.366 | -0.338 | -0.188 | — |
| chr17_19649065_A_G | chr17:19649065 | 0.363 | 0.350 | 0.188 | — |
| chr17_19648777_C_T | chr17:19648777 | -0.359 | -0.058 | 0.000 | — |
| chr17_19648896_A_T | chr17:19648896 | 0.359 | 0.223 | 0.176 | — |
| chr17_19648960_C_A | chr17:19648960 | -0.359 | -0.195 | -0.129 | — |
| chr17_19649049_G_C | chr17:19649049 | -0.359 | -0.058 | -0.294 | — |
| chr17_19649054_A_G | chr17:19649054 | -0.359 | -0.107 | -0.300 | — |
| chr17_19648899_C_G | chr17:19648899 | -0.356 | -0.109 | -0.353 | — |
| chr17_19649031_G_T | chr17:19649031 | -0.356 | -0.226 | -0.165 | — |
| chr17_19648817_C_G | chr17:19648817 | -0.353 | -0.234 | 0.094 | <0.001% |
| chr17_19648843_T_A | chr17:19648843 | -0.353 | -0.117 | 0.082 | — |
| chr17_19648845_T_G | chr17:19648845 | -0.353 | -0.137 | -0.047 | — |
| chr17_19648847_G_C | chr17:19648847 | 0.353 | 0.152 | 0.059 | — |
| chr17_19648868_C_A | chr17:19648868 | -0.353 | -0.287 | -0.129 | <0.001% |
| chr17_19648938_C_A | chr17:19648938 | 0.353 | 0.173 | 0.129 | — |
| chr17_19649068_A_G | chr17:19649068 | 0.353 | 0.358 | 0.365 | — |
| chr17_19648956_T_A | chr17:19648956 | 0.349 | 0.266 | 0.306 | — |
| chr17_19648828_C_T | chr17:19648828 | -0.346 | -0.157 | -0.224 | — |
| chr17_19648901_T_G | chr17:19648901 | -0.343 | -0.175 | -0.224 | — |
| chr17_19648798_G_C | chr17:19648798 | 0.339 | 0.109 | -0.094 | — |
| chr17_19648834_A_C | chr17:19648834 | 0.339 | 0.107 | 0.012 | — |
| chr17_19648848_G_T | chr17:19648848 | 0.339 | 0.147 | -0.141 | 0.0013% |
| chr17_19648860_G_A | chr17:19648860 | 0.339 | 0.091 | 0.024 | — |
| chr17_19648884_G_C | chr17:19648884 | 0.339 | 0.135 | 0.306 | — |
| chr17_19648907_T_C | chr17:19648907 | -0.339 | -0.373 | -0.118 | <0.001% |
| chr17_19648926_A_C | chr17:19648926 | -0.060 | -0.107 | -0.600 | — |
| chr17_19649022_G_A | chr17:19649022 | 0.339 | 0.335 | 0.135 | — |
| chr17_19648883_G_A | chr17:19648883 | -0.336 | -0.122 | -0.200 | — |
| chr17_19649030_T_G | chr17:19649030 | -0.336 | -0.188 | -0.047 | — |
| chr17_19648784_A_C | chr17:19648784 | 0.333 | 0.038 | 0.235 | — |
| chr17_19648804_G_C | chr17:19648804 | -0.333 | -0.261 | -0.118 | — |
| chr17_19648860_G_T | chr17:19648860 | 0.333 | 0.208 | 0.235 | — |
| chr17_19648901_T_C | chr17:19648901 | -0.333 | -0.216 | -0.212 | — |
| chr17_19649031_G_C | chr17:19649031 | -0.333 | -0.226 | -0.100 | — |
| chr17_19648774_T_G | chr17:19648774 | -0.329 | -0.051 | -0.106 | — |
| chr17_19648923_C_T | chr17:19648923 | 0.329 | 0.173 | 0.094 | 0.0013% |
| chr17_19649079_G_T | chr17:19649079 | 0.329 | 0.028 | 0.235 | — |
| chr17_19648803_C_G | chr17:19648803 | -0.326 | -0.401 | 0.129 | — |
| chr17_19648847_G_T | chr17:19648847 | 0.326 | 0.168 | 0.000 | — |
| chr17_19648927_C_A | chr17:19648927 | 0.326 | 0.193 | 0.188 | — |
| chr17_19648908_G_A | chr17:19648908 | -0.323 | -0.312 | -0.106 | — |
| chr17_19648997_G_C | chr17:19648997 | -0.323 | -0.312 | -0.229 | — |
| chr17_19648779_G_C | chr17:19648779 | 0.319 | 0.180 | 0.200 | — |
| chr17_19648780_T_G | chr17:19648780 | -0.319 | -0.018 | 0.000 | <0.001% |
| chr17_19648832_T_G | chr17:19648832 | -0.319 | -0.198 | 0.047 | — |
| chr17_19648908_G_T | chr17:19648908 | -0.319 | -0.332 | -0.235 | — |
| chr17_19648962_G_T | chr17:19648962 | 0.319 | 0.223 | 0.165 | — |
| chr17_19648897_G_T | chr17:19648897 | -0.316 | -0.185 | -0.294 | — |
| chr17_19648943_G_T | chr17:19648943 | 0.316 | 0.033 | 0.141 | — |
| chr17_19648809_T_G | chr17:19648809 | -0.313 | -0.228 | 0.141 | — |
| chr17_19648895_G_A | chr17:19648895 | -0.313 | -0.203 | -0.176 | — |
| chr17_19648905_C_A | chr17:19648905 | -0.313 | -0.419 | -0.306 | — |
| chr17_19648773_C_G | chr17:19648773 | -0.309 | -0.112 | -0.012 | — |
| chr17_19648881_G_C | chr17:19648881 | -0.309 | -0.221 | -0.094 | <0.001% |
| chr17_19648892_G_A | chr17:19648892 | -0.309 | -0.170 | -0.329 | — |
| chr17_19649015_G_C | chr17:19649015 | 0.309 | 0.259 | 0.200 | — |
| chr17_19648797_G_A | chr17:19648797 | 0.306 | 0.457 | 0.071 | — |
| chr17_19648833_G_C | chr17:19648833 | 0.306 | 0.152 | 0.188 | — |
| chr17_19648866_C_G | chr17:19648866 | 0.306 | -0.089 | 0.118 | — |
| chr17_19648943_G_C | chr17:19648943 | 0.306 | 0.165 | 0.176 | — |
| chr17_19648963_G_C | chr17:19648963 | 0.306 | 0.223 | 0.082 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.