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CYP1A1
receptor: AhRTier 1
CAMIP causal chains
AhR
Diminished AhR-mediated transactivation of CYP1A1, reducing both basal and inducible CYP1A1 expression and thereby attenuating local bioactivation of procarcinogens such as benzo[a]pyrene.
Drug context: deferasirox; carbamazepine; phenobarbital; phenytoin; valproic acid; capecitabine
Scored variants near CYP1A1
chr15:74,619,541..74,825,528, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr15_74726000_C_A | chr15:74726000 | 0.943 | 0.754 | 1.000 | — |
| chr15_74725959_G_T | chr15:74725959 | -0.266 | 0.340 | 1.000 | — |
| chr15_74725997_C_G | chr15:74725997 | 0.561 | 0.265 | 1.000 | — |
| chr15_74725977_C_G | chr15:74725977 | -0.717 | -0.655 | -1.000 | — |
| chr15_74725954_T_A | chr15:74725954 | 0.677 | 0.763 | 1.000 | — |
| chr15_74725987_C_A | chr15:74725987 | -0.639 | -0.353 | 0.482 | — |
| chr15_74725954_T_C | chr15:74725954 | -0.614 | -0.581 | -0.865 | — |
| chr15_74725978_G_C | chr15:74725978 | -0.577 | -0.577 | -1.000 | — |
| chr15_74725976_G_A | chr15:74725976 | -0.567 | -0.641 | -0.941 | <0.001% |
| chr15_74725979_G_A | chr15:74725979 | -0.556 | -0.660 | -0.835 | — |
| chr15_74725956_C_T | chr15:74725956 | 0.537 | 0.468 | 0.812 | — |
| chr15_74725980_G_C | chr15:74725980 | -0.532 | -0.685 | -0.665 | — |
| chr15_74725976_G_T | chr15:74725976 | -0.517 | -0.591 | -0.882 | — |
| chr15_74725999_C_A | chr15:74725999 | 0.516 | 0.259 | 0.635 | — |
| chr15_74725978_G_T | chr15:74725978 | -0.483 | -0.485 | -0.906 | — |
| chr15_74725998_T_A | chr15:74725998 | -0.512 | -0.712 | -0.800 | — |
| chr15_74725982_C_G | chr15:74725982 | -0.491 | -0.555 | -0.782 | — |
| chr15_74725998_T_C | chr15:74725998 | -0.463 | -0.536 | -0.824 | — |
| chr15_74725971_C_G | chr15:74725971 | -0.453 | -0.392 | -0.700 | — |
| chr15_74725974_G_C | chr15:74725974 | -0.338 | -0.505 | -0.771 | — |
| chr15_74725975_G_C | chr15:74725975 | -0.413 | -0.563 | -0.759 | — |
| chr15_74725979_G_C | chr15:74725979 | -0.398 | -0.570 | -0.759 | — |
| chr15_74725975_G_T | chr15:74725975 | -0.416 | -0.543 | -0.724 | — |
| chr15_74725987_C_T | chr15:74725987 | -0.406 | -0.405 | -0.306 | — |
| chr15_74725974_G_T | chr15:74725974 | -0.338 | -0.504 | -0.712 | — |
| chr15_74725930_A_C | chr15:74725930 | 0.265 | 0.273 | 0.706 | — |
| chr15_74725975_G_A | chr15:74725975 | -0.386 | -0.504 | -0.706 | 0.0020% |
| chr15_74725996_C_G | chr15:74725996 | -0.396 | -0.665 | -0.329 | — |
| chr15_74725993_T_A | chr15:74725993 | -0.391 | -0.581 | -0.447 | — |
| chr15_74725978_G_A | chr15:74725978 | -0.344 | -0.377 | -0.682 | — |
| chr15_74725987_C_G | chr15:74725987 | -0.384 | -0.416 | -0.194 | — |
| chr15_74725997_C_T | chr15:74725997 | -0.088 | -0.113 | 0.647 | <0.001% |
| chr15_74725905_G_C | chr15:74725905 | 0.363 | 0.282 | 0.600 | — |
| chr15_74725951_G_T | chr15:74725951 | -0.270 | -0.367 | -0.629 | — |
| chr15_74725937_T_C | chr15:74725937 | -0.349 | -0.188 | -0.294 | — |
| chr15_74725976_G_C | chr15:74725976 | -0.349 | -0.390 | -0.612 | — |
| chr15_74725966_G_C | chr15:74725966 | 0.336 | 0.165 | 0.335 | — |
| chr15_74725981_G_T | chr15:74725981 | -0.333 | -0.325 | -0.576 | — |
| chr15_74725996_C_T | chr15:74725996 | -0.329 | -0.590 | -0.271 | 0.019% |
| chr15_74725909_C_G | chr15:74725909 | 0.324 | 0.144 | 0.356 | — |
| chr15_74725977_C_T | chr15:74725977 | -0.319 | -0.344 | -0.441 | — |
| chr15_74725985_C_A | chr15:74725985 | 0.311 | 0.523 | 0.088 | — |
| chr15_74725993_T_G | chr15:74725993 | -0.308 | -0.466 | -0.365 | 0.012% |
| chr15_74725912_C_A | chr15:74725912 | 0.304 | 0.282 | 0.359 | — |
| chr15_74725993_T_C | chr15:74725993 | -0.301 | -0.426 | -0.235 | — |
| chr15_74725982_C_A | chr15:74725982 | -0.236 | -0.299 | -0.518 | — |
| chr15_74725955_A_T | chr15:74725955 | -0.281 | -0.294 | -0.376 | — |
| chr15_74725955_A_C | chr15:74725955 | -0.279 | -0.213 | -0.300 | — |
| chr15_74725988_C_A | chr15:74725988 | -0.275 | -0.280 | -0.259 | — |
| chr15_74725942_A_C | chr15:74725942 | 0.216 | 0.173 | 0.482 | — |
| chr15_74725995_A_T | chr15:74725995 | -0.271 | -0.456 | -0.094 | — |
| chr15_74725995_A_C | chr15:74725995 | -0.270 | -0.387 | -0.071 | — |
| chr15_74725973_G_T | chr15:74725973 | 0.201 | 0.279 | 0.471 | — |
| chr15_74725871_T_C | chr15:74725871 | 0.079 | 0.159 | 0.465 | — |
| chr15_74725933_T_C | chr15:74725933 | 0.236 | 0.266 | 0.465 | — |
| chr15_74725981_G_C | chr15:74725981 | -0.221 | -0.268 | -0.459 | — |
| chr15_74725958_A_T | chr15:74725958 | -0.128 | -0.174 | -0.453 | — |
| chr15_74725894_T_A | chr15:74725894 | 0.199 | 0.118 | 0.450 | — |
| chr15_74725894_T_G | chr15:74725894 | 0.191 | 0.154 | 0.444 | — |
| chr15_74725896_G_C | chr15:74725896 | -0.250 | -0.220 | -0.029 | — |
| chr15_74725950_A_C | chr15:74725950 | 0.097 | 0.135 | 0.435 | — |
| chr15_74725953_C_G | chr15:74725953 | -0.245 | -0.410 | -0.435 | — |
| chr15_74725977_C_A | chr15:74725977 | -0.245 | -0.315 | -0.347 | — |
| chr15_74725925_C_G | chr15:74725925 | -0.244 | -0.187 | -0.182 | — |
| chr15_74725971_C_T | chr15:74725971 | -0.120 | -0.240 | -0.424 | — |
| chr15_74725952_C_G | chr15:74725952 | -0.234 | -0.218 | -0.276 | — |
| chr15_74725936_C_A | chr15:74725936 | -0.167 | -0.228 | -0.412 | — |
| chr15_74725984_G_T | chr15:74725984 | 0.087 | 0.027 | 0.412 | — |
| chr15_74725949_C_A | chr15:74725949 | -0.230 | -0.217 | -0.306 | — |
| chr15_74725918_C_T | chr15:74725918 | -0.049 | 0.076 | 0.406 | <0.001% |
| chr15_74725943_G_T | chr15:74725943 | -0.145 | -0.165 | -0.406 | — |
| chr15_74725980_G_T | chr15:74725980 | -0.176 | -0.344 | -0.406 | — |
| chr15_74725905_G_A | chr15:74725905 | 0.178 | 0.148 | 0.400 | — |
| chr15_74725931_G_C | chr15:74725931 | 0.111 | 0.201 | 0.400 | — |
| chr15_74725973_G_C | chr15:74725973 | -0.226 | -0.319 | -0.341 | — |
| chr15_74725908_C_G | chr15:74725908 | 0.217 | 0.194 | 0.229 | 0.0013% |
| chr15_74725934_G_C | chr15:74725934 | 0.196 | 0.282 | 0.382 | — |
| chr15_74725953_C_T | chr15:74725953 | -0.206 | -0.234 | -0.382 | — |
| chr15_74725901_T_C | chr15:74725901 | 0.211 | 0.168 | 0.106 | — |
| chr15_74725981_G_A | chr15:74725981 | -0.175 | -0.123 | -0.371 | — |
| chr15_74725994_G_T | chr15:74725994 | -0.210 | -0.382 | -0.306 | — |
| chr15_74725938_C_G | chr15:74725938 | 0.201 | 0.136 | 0.306 | — |
| chr15_74725904_T_G | chr15:74725904 | 0.153 | 0.098 | 0.353 | — |
| chr15_74725953_C_A | chr15:74725953 | -0.200 | -0.161 | -0.329 | — |
| chr15_74725952_C_A | chr15:74725952 | -0.199 | -0.168 | -0.306 | 0.016% |
| chr15_74725996_C_A | chr15:74725996 | -0.196 | -0.359 | -0.188 | — |
| chr15_74725896_G_T | chr15:74725896 | -0.105 | -0.073 | -0.341 | — |
| chr15_74725920_C_G | chr15:74725920 | -0.192 | -0.210 | -0.041 | — |
| chr15_74725932_A_G | chr15:74725932 | 0.191 | 0.093 | 0.053 | — |
| chr15_74725913_T_G | chr15:74725913 | 0.048 | 0.020 | 0.335 | — |
| chr15_74725952_C_T | chr15:74725952 | -0.170 | -0.179 | -0.335 | — |
| chr15_74725991_G_C | chr15:74725991 | 0.060 | 0.105 | -0.329 | — |
| chr15_74725984_G_C | chr15:74725984 | -0.185 | -0.212 | -0.235 | — |
| chr15_74725994_G_C | chr15:74725994 | -0.185 | -0.203 | -0.035 | — |
| chr15_74725869_C_G | chr15:74725869 | 0.126 | 0.128 | 0.321 | — |
| chr15_74725995_A_G | chr15:74725995 | -0.181 | -0.330 | 0.047 | — |
| chr15_74725905_G_T | chr15:74725905 | 0.068 | 0.146 | 0.318 | — |
| chr15_74725926_G_C | chr15:74725926 | -0.037 | -0.119 | -0.318 | 0.0013% |
| chr15_74725929_C_A | chr15:74725929 | -0.119 | -0.121 | -0.312 | — |
| chr15_74725964_C_T | chr15:74725964 | -0.125 | -0.211 | -0.312 | — |
| chr15_74725972_G_T | chr15:74725972 | -0.176 | -0.145 | -0.224 | <0.001% |
| chr15_74725879_C_G | chr15:74725879 | 0.174 | 0.241 | 0.274 | — |
| chr15_74725909_C_T | chr15:74725909 | 0.169 | 0.109 | 0.018 | — |
| chr15_74725924_G_A | chr15:74725924 | -0.066 | -0.051 | -0.294 | — |
| chr15_74725948_A_T | chr15:74725948 | 0.131 | 0.207 | 0.294 | — |
| chr15_74725988_C_G | chr15:74725988 | -0.166 | -0.199 | -0.165 | <0.001% |
| chr15_74725908_C_T | chr15:74725908 | 0.046 | -0.055 | -0.288 | — |
| chr15_74725965_G_T | chr15:74725965 | -0.083 | -0.011 | -0.288 | <0.001% |
| chr15_74725954_T_G | chr15:74725954 | -0.162 | -0.122 | -0.171 | — |
| chr15_74725891_T_G | chr15:74725891 | 0.095 | 0.131 | 0.285 | — |
| chr15_74725896_G_A | chr15:74725896 | -0.109 | -0.105 | -0.282 | — |
| chr15_74725955_A_G | chr15:74725955 | 0.073 | -0.003 | 0.282 | — |
| chr15_74725956_C_A | chr15:74725956 | -0.138 | -0.119 | -0.282 | — |
| chr15_74725968_A_G | chr15:74725968 | -0.156 | -0.203 | -0.271 | — |
| chr15_74725989_G_T | chr15:74725989 | 0.000 | 0.126 | -0.276 | 0.0013% |
| chr15_74725904_T_A | chr15:74725904 | 0.115 | 0.100 | 0.265 | — |
| chr15_74725908_C_A | chr15:74725908 | 0.149 | 0.172 | 0.135 | — |
| chr15_74725888_T_G | chr15:74725888 | 0.111 | 0.129 | 0.259 | — |
| chr15_74725982_C_T | chr15:74725982 | -0.045 | -0.018 | -0.259 | — |
| chr15_74725984_G_A | chr15:74725984 | 0.073 | 0.061 | 0.259 | — |
| chr15_74725972_G_C | chr15:74725972 | -0.145 | -0.184 | -0.212 | — |
| chr15_74725979_G_T | chr15:74725979 | -0.145 | -0.147 | -0.176 | — |
| chr15_74725926_G_A | chr15:74725926 | -0.144 | -0.112 | -0.159 | — |
| chr15_74725911_A_G | chr15:74725911 | 0.143 | 0.060 | 0.118 | — |
| chr15_74725960_G_C | chr15:74725960 | 0.067 | 0.098 | 0.253 | — |
| chr15_74725992_G_A | chr15:74725992 | 0.143 | 0.180 | 0.047 | — |
| chr15_74725933_T_G | chr15:74725933 | 0.142 | 0.130 | 0.147 | — |
| chr15_74725862_G_T | chr15:74725862 | 0.140 | 0.039 | 0.009 | — |
| chr15_74725871_T_G | chr15:74725871 | 0.037 | 0.081 | 0.247 | — |
| chr15_74725921_T_C | chr15:74725921 | -0.067 | -0.117 | -0.247 | — |
| chr15_74725959_G_C | chr15:74725959 | 0.045 | 0.071 | 0.247 | — |
| chr15_74725998_T_G | chr15:74725998 | -0.017 | -0.180 | 0.247 | <0.001% |
| chr15_74725912_C_G | chr15:74725912 | 0.139 | 0.123 | 0.135 | — |
| chr15_74725870_A_C | chr15:74725870 | 0.062 | 0.163 | 0.244 | — |
| chr15_74725937_T_A | chr15:74725937 | -0.138 | -0.158 | -0.176 | — |
| chr15_74725910_C_A | chr15:74725910 | 0.137 | 0.069 | 0.041 | — |
| chr15_74725924_G_T | chr15:74725924 | -0.056 | -0.100 | -0.241 | — |
| chr15_74725940_C_G | chr15:74725940 | 0.136 | 0.050 | 0.141 | — |
| chr15_74725902_T_A | chr15:74725902 | 0.133 | 0.117 | 0.141 | — |
| chr15_74725903_T_C | chr15:74725903 | 0.133 | 0.073 | 0.091 | — |
| chr15_74725944_C_G | chr15:74725944 | -0.133 | -0.018 | -0.029 | — |
| chr15_74725967_C_G | chr15:74725967 | -0.133 | -0.133 | -0.218 | — |
| chr15_74725970_G_C | chr15:74725970 | 0.133 | 0.155 | 0.147 | — |
| chr15_74725980_G_A | chr15:74725980 | 0.120 | 0.195 | 0.235 | — |
| chr15_74725917_A_G | chr15:74725917 | 0.132 | 0.098 | 0.076 | — |
| chr15_74725967_C_T | chr15:74725967 | -0.130 | -0.133 | -0.112 | — |
| chr15_74725867_T_G | chr15:74725867 | 0.052 | 0.081 | 0.226 | — |
| chr15_74725912_C_T | chr15:74725912 | 0.126 | 0.100 | 0.094 | — |
| chr15_74725941_C_T | chr15:74725941 | 0.126 | 0.086 | 0.147 | — |
| chr15_74725966_G_A | chr15:74725966 | 0.052 | 0.006 | -0.224 | 0.0013% |
| chr15_74725966_G_T | chr15:74725966 | 0.126 | 0.114 | 0.165 | — |
| chr15_74725989_G_A | chr15:74725989 | -0.085 | -0.051 | -0.224 | 3.31% |
| chr15_74725870_A_T | chr15:74725870 | 0.031 | 0.115 | 0.221 | <0.001% |
| chr15_74725891_T_A | chr15:74725891 | 0.049 | 0.086 | 0.221 | — |
| chr15_74725929_C_T | chr15:74725929 | 0.124 | 0.123 | 0.171 | — |
| chr15_74725872_C_G | chr15:74725872 | 0.024 | 0.067 | 0.218 | 0.0013% |
| chr15_74725957_C_A | chr15:74725957 | -0.123 | -0.109 | -0.071 | — |
| chr15_74725970_G_A | chr15:74725970 | 0.123 | 0.089 | 0.047 | <0.001% |
| chr15_74725854_G_T | chr15:74725854 | -0.042 | -0.088 | -0.215 | — |
| chr15_74725949_C_T | chr15:74725949 | -0.087 | -0.146 | -0.212 | — |
| chr15_74725967_C_A | chr15:74725967 | -0.120 | -0.128 | -0.206 | — |
| chr15_74725986_C_T | chr15:74725986 | -0.120 | -0.241 | -0.094 | — |
| chr15_74725892_C_A | chr15:74725892 | 0.074 | 0.138 | 0.206 | — |
| chr15_74725948_A_C | chr15:74725948 | 0.033 | 0.086 | 0.206 | — |
| chr15_74725962_C_T | chr15:74725962 | -0.116 | -0.115 | -0.159 | — |
| chr15_74725983_T_G | chr15:74725983 | -0.116 | -0.157 | -0.159 | — |
| chr15_74725870_A_G | chr15:74725870 | 0.039 | 0.077 | 0.203 | — |
| chr15_74725893_T_C | chr15:74725893 | 0.047 | 0.060 | 0.200 | — |
| chr15_74725988_C_T | chr15:74725988 | -0.058 | 0.006 | -0.200 | — |
| chr15_74725860_G_C | chr15:74725860 | -0.111 | 0.000 | -0.044 | <0.001% |
| chr15_74725911_A_C | chr15:74725911 | -0.111 | -0.040 | -0.082 | — |
| chr15_74725932_A_C | chr15:74725932 | 0.111 | 0.056 | 0.165 | — |
| chr15_74725891_T_C | chr15:74725891 | 0.111 | 0.132 | 0.094 | — |
| chr15_74725904_T_C | chr15:74725904 | 0.099 | 0.056 | 0.194 | — |
| chr15_74725916_A_C | chr15:74725916 | -0.074 | -0.108 | 0.194 | — |
| chr15_74725941_C_G | chr15:74725941 | 0.110 | 0.055 | 0.176 | — |
| chr15_74725951_G_C | chr15:74725951 | -0.110 | -0.048 | 0.018 | — |
| chr15_74725928_G_C | chr15:74725928 | -0.108 | -0.131 | -0.141 | — |
| chr15_74725825_G_T | chr15:74725825 | -0.043 | -0.089 | -0.188 | — |
| chr15_74725929_C_G | chr15:74725929 | 0.077 | 0.055 | 0.188 | — |
| chr15_74725961_A_C | chr15:74725961 | -0.038 | -0.104 | -0.188 | — |
| chr15_74725991_G_A | chr15:74725991 | 0.105 | 0.188 | 0.094 | <0.001% |
| chr15_74725881_C_G | chr15:74725881 | -0.104 | 0.012 | 0.000 | — |
| chr15_74725936_C_T | chr15:74725936 | -0.104 | -0.122 | -0.141 | — |
| chr15_74725921_T_G | chr15:74725921 | -0.103 | -0.109 | 0.029 | — |
| chr15_74725997_C_A | chr15:74725997 | -0.090 | -0.315 | 0.118 | — |
| chr15_74725903_T_G | chr15:74725903 | 0.102 | 0.053 | 0.006 | — |
| chr15_74725923_G_C | chr15:74725923 | 0.101 | -0.070 | -0.041 | — |
| chr15_74725983_T_A | chr15:74725983 | -0.101 | -0.147 | -0.076 | — |
| chr15_74725884_G_C | chr15:74725884 | 0.084 | 0.064 | 0.176 | — |
| chr15_74725913_T_A | chr15:74725913 | 0.021 | 0.000 | 0.176 | — |
| chr15_74725926_G_T | chr15:74725926 | -0.062 | -0.072 | -0.176 | — |
| chr15_74725931_G_A | chr15:74725931 | 0.017 | 0.121 | 0.176 | — |
| chr15_74725989_G_C | chr15:74725989 | 0.088 | 0.164 | -0.176 | — |
| chr15_74725932_A_T | chr15:74725932 | 0.099 | 0.143 | 0.171 | — |
| chr15_74725866_C_G | chr15:74725866 | 0.067 | 0.089 | 0.174 | — |
| chr15_74725873_C_T | chr15:74725873 | -0.022 | 0.015 | 0.174 | — |
| chr15_74725895_C_A | chr15:74725895 | 0.072 | 0.112 | 0.174 | — |
| chr15_74725869_C_T | chr15:74725869 | 0.097 | 0.077 | 0.165 | — |
| chr15_74725815_G_C | chr15:74725815 | 0.037 | 0.034 | 0.171 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.