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CYP1B1
receptor: AhRTier 1
CAMIP causal chains
AhR
Impaired receptor-mediated signaling that abolishes both the basal constitutive expression and chemical inducibility of CYP1B1 in extrahepatic tissues, perturbing the localized pathway of estradiol 4-hydroxylation and procarcinogen activation that drives tissue-specific susceptibility to malignancies.
Affected substrate drugs (PharmGKB): cyclophosphamide; doxorubicin; fluorouracil; risperidone; epirubicin; paclitaxel
Scored variants near CYP1B1
chr2:37,967,509..38,176,151, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr2_38015061_T_G | chr2:38015061 | 17,728 | 4,736 | 20,000 | — |
| chr2_38076076_G_A | chr2:38076076 | 12,544 | 1,152 | 5,632 | — |
| chr2_38075966_G_C | chr2:38075966 | 12,288 | 2,592 | 7,936 | — |
| chr2_38076022_G_C | chr2:38076022 | 7,424 | 1,216 | 6,144 | — |
| chr2_38076020_T_G | chr2:38076020 | 6,656 | 1,216 | 3,072 | — |
| chr2_38075971_G_T | chr2:38075971 | 6,144 | 704 | 1,792 | — |
| chr2_38076015_G_T | chr2:38076015 | 5,632 | 864 | 2,048 | — |
| chr2_38076038_C_G | chr2:38076038 | 5,632 | 512 | 2,304 | — |
| chr2_38075942_C_G | chr2:38075942 | -5,376 | -544 | -2,304 | — |
| chr2_38076037_C_A | chr2:38076037 | 5,248 | 992 | -3,072 | — |
| chr2_38075967_A_C | chr2:38075967 | 5,120 | 1,728 | 3,584 | — |
| chr2_38076030_G_C | chr2:38076030 | 5,120 | 1,120 | 2,304 | — |
| chr2_38076127_T_G | chr2:38076127 | -5,120 | -32 | -1,792 | — |
| chr2_38075969_G_C | chr2:38075969 | 4,992 | 1,024 | 5,120 | — |
| chr2_38076062_G_T | chr2:38076062 | 4,992 | 960 | 3,840 | — |
| chr2_38076122_A_T | chr2:38076122 | -4,864 | -1,664 | -5,632 | — |
| chr2_38076015_G_C | chr2:38076015 | 4,864 | 640 | 2,048 | — |
| chr2_38076024_A_C | chr2:38076024 | 4,864 | 544 | 4,864 | — |
| chr2_38076093_C_G | chr2:38076093 | 4,864 | 448 | -1,280 | — |
| chr2_38015049_A_C | chr2:38015049 | 4,816 | 1,840 | 6,560 | — |
| chr2_38075935_G_A | chr2:38075935 | 4,736 | 480 | -256 | — |
| chr2_38076062_G_C | chr2:38076062 | 4,736 | 896 | 3,072 | — |
| chr2_38075968_T_C | chr2:38075968 | 4,608 | 1,344 | 5,888 | — |
| chr2_38075966_G_T | chr2:38075966 | 4,608 | 1,408 | 3,072 | — |
| chr2_38076102_C_G | chr2:38076102 | 4,608 | 288 | 2,048 | — |
| chr2_38076008_C_A | chr2:38076008 | 4,480 | 992 | 2,048 | — |
| chr2_38076013_G_T | chr2:38076013 | 4,480 | 640 | 1,024 | — |
| chr2_38076113_A_C | chr2:38076113 | -4,480 | -832 | -3,840 | — |
| chr2_38075966_G_A | chr2:38075966 | 4,352 | 1,472 | 4,864 | — |
| chr2_38075940_G_A | chr2:38075940 | 4,352 | 800 | 1,536 | 3.9e-5 |
| chr2_38075942_C_A | chr2:38075942 | -4,352 | -64 | 512 | — |
| chr2_38075952_A_G | chr2:38075952 | -4,352 | -512 | -1,792 | — |
| chr2_38075970_G_T | chr2:38075970 | 4,352 | 928 | 3,072 | — |
| chr2_38076080_C_T | chr2:38076080 | -4,352 | -320 | -1,792 | — |
| chr2_38076063_G_C | chr2:38076063 | 4,224 | 1,024 | 3,840 | — |
| chr2_38076064_G_T | chr2:38076064 | 4,224 | 608 | 2,304 | — |
| chr2_38075983_G_C | chr2:38075983 | 4,096 | 864 | 5,120 | — |
| chr2_38075949_A_C | chr2:38075949 | -4,096 | -192 | -512 | — |
| chr2_38075950_G_T | chr2:38075950 | -4,096 | -864 | -2,560 | — |
| chr2_38075963_T_C | chr2:38075963 | 4,096 | 896 | 4,096 | — |
| chr2_38075965_G_C | chr2:38075965 | 4,096 | 1,184 | 3,840 | — |
| chr2_38076004_G_C | chr2:38076004 | -4,096 | -576 | -2,816 | — |
| chr2_38076014_G_T | chr2:38076014 | 4,096 | 480 | 1,536 | — |
| chr2_38076030_G_A | chr2:38076030 | -4,096 | -128 | 256 | — |
| chr2_38076078_G_C | chr2:38076078 | -4,096 | -64 | -768 | — |
| chr2_38076125_G_C | chr2:38076125 | -4,096 | -480 | 768 | — |
| chr2_38075982_G_C | chr2:38075982 | 3,840 | 608 | 5,120 | — |
| chr2_38075986_C_A | chr2:38075986 | 3,840 | 1,056 | 4,352 | — |
| chr2_38075949_A_G | chr2:38075949 | -3,840 | -704 | -1,024 | — |
| chr2_38076016_G_A | chr2:38076016 | 3,840 | 352 | 2,048 | — |
| chr2_38076016_G_T | chr2:38076016 | 3,840 | -64 | -1,280 | — |
| chr2_38076097_C_G | chr2:38076097 | -3,840 | -32 | -1,024 | — |
| chr2_38075961_A_G | chr2:38075961 | -3,712 | -352 | -2,560 | 6.6e-6 |
| chr2_38076127_T_C | chr2:38076127 | -3,712 | -192 | -512 | — |
| chr2_38075974_C_T | chr2:38075974 | -3,584 | -1,216 | -6,912 | 6.6e-6 |
| chr2_38075950_G_C | chr2:38075950 | -3,584 | -608 | -1,280 | — |
| chr2_38075952_A_C | chr2:38075952 | -3,584 | -160 | -768 | — |
| chr2_38075970_G_A | chr2:38075970 | 3,584 | 768 | 2,048 | — |
| chr2_38075971_G_C | chr2:38075971 | 3,584 | 672 | 2,048 | — |
| chr2_38076015_G_A | chr2:38076015 | 3,584 | 480 | 0 | — |
| chr2_38076038_C_A | chr2:38076038 | 3,584 | 512 | 512 | — |
| chr2_38076075_G_T | chr2:38076075 | 3,584 | 544 | 1,536 | — |
| chr2_38076077_C_G | chr2:38076077 | -3,584 | 448 | 1,280 | — |
| chr2_38076063_G_A | chr2:38076063 | 3,456 | 672 | 3,840 | — |
| chr2_38076111_G_T | chr2:38076111 | -3,456 | -384 | -512 | — |
| chr2_38075935_G_T | chr2:38075935 | 3,328 | 128 | -1,024 | — |
| chr2_38076003_C_A | chr2:38076003 | 3,328 | 448 | 1,280 | — |
| chr2_38076079_T_C | chr2:38076079 | -3,328 | 0 | 0 | — |
| chr2_38076097_C_A | chr2:38076097 | -3,328 | -448 | -2,304 | 3.3e-5 |
| chr2_38076107_A_C | chr2:38076107 | 3,328 | 224 | 3,072 | — |
| chr2_38075969_G_T | chr2:38075969 | 3,200 | 384 | 768 | — |
| chr2_38076061_G_C | chr2:38076061 | 3,200 | 544 | 2,048 | 1.3e-5 |
| chr2_38075938_T_C | chr2:38075938 | -3,072 | -160 | 1,024 | — |
| chr2_38075948_C_A | chr2:38075948 | -3,072 | -480 | -2,304 | — |
| chr2_38075951_G_C | chr2:38075951 | 3,072 | 640 | 2,816 | — |
| chr2_38075983_G_T | chr2:38075983 | 3,072 | 640 | 1,792 | — |
| chr2_38075984_T_G | chr2:38075984 | -3,072 | -544 | -1,024 | — |
| chr2_38076014_G_C | chr2:38076014 | 3,072 | 480 | 3,072 | — |
| chr2_38076032_G_T | chr2:38076032 | 3,072 | 384 | 1,024 | — |
| chr2_38076042_C_A | chr2:38076042 | -3,072 | -224 | -3,072 | — |
| chr2_38076104_C_G | chr2:38076104 | 3,072 | 320 | 2,304 | — |
| chr2_38075943_A_G | chr2:38075943 | -2,944 | -288 | -3,328 | 6.6e-6 |
| chr2_38076054_T_C | chr2:38076054 | 2,944 | 608 | 3,072 | — |
| chr2_38075936_C_T | chr2:38075936 | 2,944 | 320 | 0 | 6.6e-6 |
| chr2_38075961_A_C | chr2:38075961 | 2,944 | 544 | 1,280 | — |
| chr2_38076121_A_C | chr2:38076121 | 2,944 | 256 | 1,792 | — |
| chr2_38076121_A_T | chr2:38076121 | 2,944 | 320 | 1,792 | — |
| chr2_38076118_C_A | chr2:38076118 | -2,816 | -448 | -5,120 | — |
| chr2_38076102_C_T | chr2:38076102 | 2,816 | 800 | 3,072 | — |
| chr2_38075936_C_G | chr2:38075936 | -2,816 | -448 | 512 | — |
| chr2_38075946_G_C | chr2:38075946 | -2,816 | -512 | -768 | — |
| chr2_38075955_G_T | chr2:38075955 | 2,816 | 128 | -1,792 | — |
| chr2_38075958_T_A | chr2:38075958 | -2,816 | -192 | 256 | — |
| chr2_38075964_G_C | chr2:38075964 | 2,816 | 672 | 2,816 | — |
| chr2_38075975_G_T | chr2:38075975 | 2,816 | 288 | -512 | — |
| chr2_38075992_T_C | chr2:38075992 | -2,816 | -224 | -768 | — |
| chr2_38075992_T_G | chr2:38075992 | -2,816 | -224 | -256 | — |
| chr2_38076029_C_A | chr2:38076029 | -2,816 | 0 | -1,024 | — |
| chr2_38076039_T_A | chr2:38076039 | 2,816 | 160 | 512 | — |
| chr2_38076081_A_T | chr2:38076081 | -2,816 | -32 | -512 | — |
| chr2_38076093_C_A | chr2:38076093 | 2,816 | -96 | -2,048 | 2.0e-5 |
| chr2_38076096_G_C | chr2:38076096 | 2,816 | 896 | 768 | — |
| chr2_38076108_A_T | chr2:38076108 | -2,816 | -544 | -1,536 | — |
| chr2_38076057_G_A | chr2:38076057 | 2,688 | 864 | 4,352 | 2.6e-5 |
| chr2_38076062_G_A | chr2:38076062 | 2,688 | 480 | 3,072 | — |
| chr2_38075934_G_A | chr2:38075934 | -2,688 | -160 | 1,280 | — |
| chr2_38075949_A_T | chr2:38075949 | -2,688 | -704 | -1,024 | — |
| chr2_38075973_A_T | chr2:38075973 | 2,688 | 32 | -768 | — |
| chr2_38075985_G_C | chr2:38075985 | -2,688 | -544 | -2,048 | — |
| chr2_38076001_C_T | chr2:38076001 | 2,688 | 352 | 0 | — |
| chr2_38076040_C_A | chr2:38076040 | -2,688 | 288 | -256 | — |
| chr2_38076071_G_T | chr2:38076071 | 2,688 | -224 | -1,024 | — |
| chr2_38076078_G_A | chr2:38076078 | -2,560 | -544 | -4,096 | — |
| chr2_38075979_A_G | chr2:38075979 | 2,560 | 448 | 2,816 | — |
| chr2_38075942_C_T | chr2:38075942 | -2,560 | -288 | -768 | 2.6e-5 |
| chr2_38075945_T_G | chr2:38075945 | -2,560 | -480 | 512 | 1.3e-5 |
| chr2_38075953_G_T | chr2:38075953 | 2,560 | 160 | 512 | — |
| chr2_38075959_G_C | chr2:38075959 | 2,560 | 416 | 1,536 | — |
| chr2_38075961_A_T | chr2:38075961 | -2,560 | -256 | -2,560 | — |
| chr2_38075964_G_T | chr2:38075964 | 2,560 | 576 | 1,280 | — |
| chr2_38075972_G_T | chr2:38075972 | 2,560 | 256 | -256 | — |
| chr2_38075977_A_T | chr2:38075977 | 2,560 | 96 | 0 | — |
| chr2_38076002_C_T | chr2:38076002 | 2,560 | 352 | 768 | — |
| chr2_38076003_C_T | chr2:38076003 | 2,560 | 320 | 512 | — |
| chr2_38076016_G_C | chr2:38076016 | 2,560 | 192 | 1,536 | — |
| chr2_38076023_C_G | chr2:38076023 | -2,560 | -288 | -256 | — |
| chr2_38076044_G_A | chr2:38076044 | -2,560 | -32 | -1,536 | — |
| chr2_38076048_T_C | chr2:38076048 | -2,560 | -96 | -1,792 | — |
| chr2_38076057_G_T | chr2:38076057 | 2,560 | 192 | -256 | — |
| chr2_38076060_T_A | chr2:38076060 | 2,560 | 576 | 2,048 | — |
| chr2_38076066_T_A | chr2:38076066 | -2,560 | -160 | 1,792 | — |
| chr2_38076091_C_A | chr2:38076091 | -2,560 | -384 | -768 | — |
| chr2_38076111_G_A | chr2:38076111 | -2,560 | -64 | 256 | — |
| chr2_38076113_A_G | chr2:38076113 | -2,560 | -224 | 2,048 | — |
| chr2_38076123_G_C | chr2:38076123 | -2,560 | -576 | -2,048 | — |
| chr2_38076127_T_A | chr2:38076127 | -2,560 | -288 | -512 | — |
| chr2_38076004_G_T | chr2:38076004 | -2,432 | -640 | -3,328 | — |
| chr2_38075934_G_T | chr2:38075934 | -2,432 | -224 | 512 | — |
| chr2_38075969_G_A | chr2:38075969 | 2,432 | 576 | 2,048 | 4.6e-5 |
| chr2_38076013_G_C | chr2:38076013 | 2,432 | 384 | 2,304 | — |
| chr2_38076054_T_A | chr2:38076054 | 2,432 | 128 | 0 | — |
| chr2_38076065_G_C | chr2:38076065 | 2,432 | 672 | 2,048 | — |
| chr2_38015052_G_C | chr2:38015052 | 2,336 | 912 | 2,400 | — |
| chr2_38076086_C_T | chr2:38076086 | -2,304 | -416 | -3,584 | — |
| chr2_38075981_G_C | chr2:38075981 | 2,304 | 352 | 2,816 | 7.0e-4 |
| chr2_38075941_T_G | chr2:38075941 | -2,304 | 128 | 256 | — |
| chr2_38075954_C_G | chr2:38075954 | -2,304 | -448 | -256 | — |
| chr2_38075967_A_T | chr2:38075967 | 2,304 | 1,152 | 256 | — |
| chr2_38075946_G_A | chr2:38075946 | -2,048 | -640 | -3,328 | — |
| chr2_38076019_C_G | chr2:38076019 | 1,920 | 224 | 3,072 | — |
| chr2_38076064_G_A | chr2:38076064 | 1,920 | 672 | 2,816 | 4.2e-4 |
| chr2_38076065_G_A | chr2:38076065 | 1,920 | 480 | 2,816 | — |
| chr2_38076067_C_G | chr2:38076067 | 1,792 | 800 | 4,352 | — |
| chr2_38076028_T_C | chr2:38076028 | 1,792 | 608 | 3,840 | — |
| chr2_38075979_A_C | chr2:38075979 | 1,792 | 256 | 3,328 | — |
| chr2_38076026_A_C | chr2:38076026 | -1,792 | -704 | -2,816 | — |
| chr2_38075947_C_T | chr2:38075947 | -1,792 | -480 | -2,560 | — |
| chr2_38075970_G_C | chr2:38075970 | 1,792 | 544 | 2,560 | 6.6e-6 |
| chr2_38075978_G_T | chr2:38075978 | 1,792 | -224 | -2,560 | — |
| chr2_38075994_G_C | chr2:38075994 | -1,792 | -608 | -2,304 | — |
| chr2_38075937_G_C | chr2:38075937 | -1,664 | -32 | 2,304 | — |
| chr2_38076087_C_A | chr2:38076087 | 1,536 | -192 | -4,352 | — |
| chr2_38076108_A_G | chr2:38076108 | 1,536 | 352 | 3,584 | 1.3e-5 |
| chr2_38075987_C_A | chr2:38075987 | -1,536 | -608 | -3,328 | — |
| chr2_38076069_G_A | chr2:38076069 | 1,536 | -416 | -3,072 | — |
| chr2_38076042_C_G | chr2:38076042 | -1,536 | -160 | -2,560 | — |
| chr2_38076059_C_T | chr2:38076059 | -1,536 | -320 | -2,560 | — |
| chr2_38075976_G_C | chr2:38075976 | 1,536 | 256 | 2,304 | 3.9e-5 |
| chr2_38076057_G_C | chr2:38076057 | 1,408 | 224 | 3,328 | — |
| chr2_38075973_A_G | chr2:38075973 | 1,408 | 896 | 2,560 | — |
| chr2_38075985_G_A | chr2:38075985 | -1,280 | -352 | -3,072 | — |
| chr2_38076112_G_C | chr2:38076112 | 1,280 | 320 | 2,816 | — |
| chr2_38076056_A_C | chr2:38076056 | 1,280 | 320 | 2,560 | — |
| chr2_38075939_C_G | chr2:38075939 | -1,280 | 192 | 2,304 | — |
| chr2_38075983_G_A | chr2:38075983 | -1,152 | -768 | -3,328 | — |
| chr2_38076053_T_G | chr2:38076053 | 1,152 | 448 | 3,072 | — |
| chr2_38076007_G_A | chr2:38076007 | -1,152 | -320 | -2,560 | — |
| chr2_38075939_C_A | chr2:38075939 | 1,152 | 416 | 2,304 | — |
| chr2_38075968_T_G | chr2:38075968 | -1,024 | 1,184 | 4,864 | — |
| chr2_38076066_T_G | chr2:38076066 | 1,024 | 512 | 3,584 | — |
| chr2_38076061_G_A | chr2:38076061 | 1,024 | 288 | 3,328 | — |
| chr2_38075995_C_A | chr2:38075995 | -896 | -352 | -3,840 | — |
| chr2_38076087_C_G | chr2:38076087 | 768 | -320 | -4,864 | — |
| chr2_38076031_A_C | chr2:38076031 | -768 | 192 | 3,584 | 6.6e-6 |
| chr2_38076068_G_T | chr2:38076068 | -768 | -640 | -3,328 | 6.6e-6 |
| chr2_38076073_G_T | chr2:38076073 | 768 | -608 | -3,072 | — |
| chr2_38076089_T_C | chr2:38076089 | -768 | 64 | 2,560 | — |
| chr2_38076120_G_T | chr2:38076120 | 640 | 448 | 3,072 | — |
| chr2_38075980_A_T | chr2:38075980 | -512 | -608 | -3,072 | — |
| chr2_38076009_C_T | chr2:38076009 | 512 | -32 | -2,560 | — |
| chr2_38076110_T_G | chr2:38076110 | 512 | 480 | 2,560 | — |
| chr2_38075991_C_G | chr2:38075991 | -512 | -256 | -2,304 | — |
| chr2_38075995_C_T | chr2:38075995 | -384 | -288 | -4,096 | — |
| chr2_38075968_T_A | chr2:38075968 | 256 | 448 | 3,328 | 6.6e-6 |
| chr2_38076026_A_G | chr2:38076026 | 256 | 32 | 3,072 | — |
| chr2_38076086_C_A | chr2:38076086 | -256 | -192 | -3,072 | — |
| chr2_38075999_G_A | chr2:38075999 | -256 | -128 | -2,816 | 1.3e-5 |
| chr2_38075945_T_C | chr2:38075945 | -256 | -64 | 2,304 | — |
| chr2_38075994_G_T | chr2:38075994 | 256 | -224 | -2,304 | — |
| chr2_38075990_G_T | chr2:38075990 | -128 | -32 | -2,816 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.