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CYP2C19
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of CYP2C19 lowers antiplatelet effect of the prodrug clopidogrel, and raises exposure of voriconazole.
Affected substrate drugs (PharmGKB): clopidogrel; voriconazole; omeprazole; lansoprazole; citalopram; escitalopram
Scored variants near CYP2C19
chr10:94,662,680..94,955,547, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_94673779_C_A | chr10:94673779 | 11,232 | 4,192 | 5,376 | — |
| chr10_94673789_G_A | chr10:94673789 | 10,368 | 4,224 | 2,240 | — |
| chr10_94673793_T_A | chr10:94673793 | 9,856 | 4,944 | 7,808 | — |
| chr10_94673773_T_A | chr10:94673773 | -8,768 | -2,128 | -9,472 | — |
| chr10_94673778_T_A | chr10:94673778 | 8,672 | 3,056 | 4,864 | — |
| chr10_94673794_C_G | chr10:94673794 | 8,512 | 3,696 | 10,880 | — |
| chr10_94673794_C_T | chr10:94673794 | 8,128 | 3,888 | 8,448 | — |
| chr10_94673773_T_G | chr10:94673773 | -7,968 | -1,744 | -8,384 | — |
| chr10_94673773_T_C | chr10:94673773 | -7,648 | -1,824 | -8,064 | — |
| chr10_94673793_T_G | chr10:94673793 | 7,520 | 3,984 | 5,888 | — |
| chr10_94673743_C_G | chr10:94673743 | 7,312 | 4,640 | 4,992 | — |
| chr10_94673731_C_T | chr10:94673731 | 7,072 | 2,192 | 6,400 | — |
| chr10_94673794_C_A | chr10:94673794 | 6,048 | 2,928 | 4,992 | — |
| chr10_94673789_G_T | chr10:94673789 | 5,472 | 3,776 | 10,752 | — |
| chr10_94673775_A_C | chr10:94673775 | -5,344 | -1,264 | -6,848 | — |
| chr10_94673792_A_C | chr10:94673792 | 5,152 | 2,400 | 4,736 | — |
| chr10_94673790_A_G | chr10:94673790 | 5,120 | 2,608 | 1,664 | — |
| chr10_94673741_A_C | chr10:94673741 | 5,008 | 2,592 | 4,800 | — |
| chr10_94673686_C_T | chr10:94673686 | 4,976 | 1,808 | 4,800 | — |
| chr10_94673780_A_C | chr10:94673780 | -4,768 | -848 | -8,064 | — |
| chr10_94673757_A_T | chr10:94673757 | -4,480 | -928 | -2,752 | — |
| chr10_94673774_T_C | chr10:94673774 | -4,448 | -1,184 | -6,848 | — |
| chr10_94673793_T_C | chr10:94673793 | 4,416 | 2,544 | 1,664 | — |
| chr10_94673731_C_A | chr10:94673731 | 4,384 | 1,488 | 4,736 | — |
| chr10_94673757_A_G | chr10:94673757 | -4,304 | -1,392 | -2,944 | — |
| chr10_94673817_T_A | chr10:94673817 | 4,256 | 1,840 | 1,600 | — |
| chr10_94673699_A_T | chr10:94673699 | 4,208 | 1,968 | 3,264 | — |
| chr10_94673737_T_A | chr10:94673737 | -4,176 | -848 | -4,928 | 1.1e-4 |
| chr10_94673709_A_C | chr10:94673709 | 4,144 | 1,344 | 4,096 | — |
| chr10_94673785_A_C | chr10:94673785 | -4,064 | -1,568 | -2,944 | — |
| chr10_94673791_C_A | chr10:94673791 | 4,064 | 2,272 | 2,112 | — |
| chr10_94673779_C_T | chr10:94673779 | -4,032 | -192 | -4,672 | — |
| chr10_94673790_A_T | chr10:94673790 | 4,032 | 2,176 | 4,032 | — |
| chr10_94673777_A_G | chr10:94673777 | -3,936 | -1,632 | -2,688 | — |
| chr10_94673774_T_G | chr10:94673774 | -3,872 | -1,728 | -4,608 | — |
| chr10_94673743_C_A | chr10:94673743 | 3,856 | 1,920 | 2,240 | — |
| chr10_94673782_C_G | chr10:94673782 | -3,712 | -1,072 | -6,016 | — |
| chr10_94673763_C_T | chr10:94673763 | -3,712 | -224 | 3,520 | — |
| chr10_94673731_C_G | chr10:94673731 | 3,696 | 1,392 | 4,352 | — |
| chr10_94673824_T_G | chr10:94673824 | 3,680 | 2,016 | 2,048 | — |
| chr10_94673742_T_C | chr10:94673742 | -3,664 | -800 | -4,544 | — |
| chr10_94673742_T_A | chr10:94673742 | -3,552 | -464 | -4,736 | — |
| chr10_94673787_A_C | chr10:94673787 | 3,552 | 1,904 | 448 | — |
| chr10_94673825_G_T | chr10:94673825 | 3,488 | 1,472 | 1,728 | — |
| chr10_94673775_A_T | chr10:94673775 | 3,424 | 1,696 | 3,648 | — |
| chr10_94673791_C_G | chr10:94673791 | 3,392 | 1,376 | 2,816 | — |
| chr10_94673780_A_T | chr10:94673780 | -3,328 | -816 | -6,912 | 6.6e-6 |
| chr10_94673791_C_T | chr10:94673791 | 3,296 | 1,456 | 1,088 | — |
| chr10_94673777_A_C | chr10:94673777 | -3,264 | -672 | -3,456 | — |
| chr10_94673779_C_G | chr10:94673779 | -3,232 | 16 | -6,016 | — |
| chr10_94673739_A_G | chr10:94673739 | -3,232 | -560 | -3,776 | — |
| chr10_94673808_A_G | chr10:94673808 | 3,072 | 1,024 | 4,032 | — |
| chr10_94673742_T_G | chr10:94673742 | -3,040 | -512 | -3,968 | — |
| chr10_94673725_C_G | chr10:94673725 | -3,024 | -1,184 | -2,432 | — |
| chr10_94673716_A_C | chr10:94673716 | -3,008 | -960 | -3,392 | — |
| chr10_94673780_A_G | chr10:94673780 | -2,880 | -720 | -5,376 | — |
| chr10_94673744_A_C | chr10:94673744 | -2,880 | -608 | -4,416 | — |
| chr10_94673809_C_T | chr10:94673809 | 2,880 | 528 | 2,176 | — |
| chr10_94673755_G_T | chr10:94673755 | -2,864 | -1,072 | -2,688 | — |
| chr10_94673776_C_A | chr10:94673776 | -2,848 | -416 | -4,672 | — |
| chr10_94673802_T_G | chr10:94673802 | 2,848 | 1,072 | 3,648 | — |
| chr10_94673746_C_A | chr10:94673746 | -2,752 | -832 | -3,392 | — |
| chr10_94673753_C_A | chr10:94673753 | -2,752 | -976 | -2,496 | — |
| chr10_94673738_G_C | chr10:94673738 | -2,736 | -320 | -3,904 | — |
| chr10_94673762_A_G | chr10:94673762 | -2,720 | -1,072 | -1,728 | — |
| chr10_94673767_T_G | chr10:94673767 | -2,720 | -736 | -2,176 | — |
| chr10_94673797_T_G | chr10:94673797 | -2,720 | -752 | -2,496 | — |
| chr10_94673722_A_T | chr10:94673722 | 2,640 | 1,200 | 3,072 | — |
| chr10_94673714_A_G | chr10:94673714 | -2,640 | -1,040 | -1,984 | — |
| chr10_94673836_T_C | chr10:94673836 | 2,592 | 432 | 1,536 | — |
| chr10_94673716_A_G | chr10:94673716 | -2,576 | -1,024 | -1,408 | — |
| chr10_94673778_T_C | chr10:94673778 | 2,560 | 992 | -384 | — |
| chr10_94673776_C_T | chr10:94673776 | -2,528 | -544 | -5,120 | — |
| chr10_94673739_A_C | chr10:94673739 | -2,512 | -352 | -3,200 | — |
| chr10_94673740_C_A | chr10:94673740 | -2,496 | -112 | -3,200 | — |
| chr10_94673745_C_T | chr10:94673745 | 2,496 | 368 | 2,752 | 6.6e-6 |
| chr10_94673776_C_G | chr10:94673776 | -2,464 | -768 | -4,544 | — |
| chr10_94673744_A_T | chr10:94673744 | -2,464 | -480 | -4,416 | — |
| chr10_94673810_C_G | chr10:94673810 | -2,464 | -704 | -1,536 | — |
| chr10_94673741_A_G | chr10:94673741 | 2,432 | -304 | 2,880 | — |
| chr10_94673790_A_C | chr10:94673790 | 2,432 | 1,552 | -512 | — |
| chr10_94673804_C_G | chr10:94673804 | -2,400 | -432 | -1,216 | — |
| chr10_94673808_A_T | chr10:94673808 | 2,400 | 880 | 2,176 | — |
| chr10_94673717_C_G | chr10:94673717 | 2,384 | 1,040 | 4,352 | — |
| chr10_94673717_C_A | chr10:94673717 | 2,384 | 832 | 3,200 | — |
| chr10_94673714_A_C | chr10:94673714 | -2,384 | -1,024 | -1,984 | — |
| chr10_94673765_G_C | chr10:94673765 | -2,368 | -464 | -2,816 | — |
| chr10_94673723_T_C | chr10:94673723 | 2,368 | 1,040 | 2,112 | — |
| chr10_94673785_A_T | chr10:94673785 | -2,368 | -848 | -832 | — |
| chr10_94673675_A_T | chr10:94673675 | 2,320 | 896 | 1,152 | — |
| chr10_94673729_A_C | chr10:94673729 | -2,288 | -720 | -896 | — |
| chr10_94673738_G_T | chr10:94673738 | 2,272 | 1,360 | 2,880 | — |
| chr10_94673693_A_C | chr10:94673693 | 2,272 | 752 | 2,240 | — |
| chr10_94673806_A_G | chr10:94673806 | 2,272 | 832 | 1,600 | — |
| chr10_94673737_T_C | chr10:94673737 | -2,240 | -400 | -2,624 | 6.6e-6 |
| chr10_94673797_T_A | chr10:94673797 | -2,240 | -496 | -2,496 | — |
| chr10_94673681_A_C | chr10:94673681 | -2,224 | -752 | -2,816 | — |
| chr10_94673746_C_G | chr10:94673746 | -2,224 | -704 | -2,560 | — |
| chr10_94673831_A_C | chr10:94673831 | -2,208 | -944 | -2,752 | — |
| chr10_94673795_A_G | chr10:94673795 | 2,208 | 1,088 | -320 | — |
| chr10_94673836_T_G | chr10:94673836 | 2,208 | 512 | 1,472 | — |
| chr10_94673657_C_A | chr10:94673657 | 2,192 | 944 | 2,176 | — |
| chr10_94673788_T_A | chr10:94673788 | -2,176 | 368 | -5,312 | — |
| chr10_94673624_C_T | chr10:94673624 | 2,160 | 1,040 | 2,304 | — |
| chr10_94673762_A_T | chr10:94673762 | -2,144 | -816 | -2,304 | — |
| chr10_94673812_A_C | chr10:94673812 | -2,144 | -528 | -1,600 | — |
| chr10_94673737_T_G | chr10:94673737 | -2,096 | 32 | -2,944 | — |
| chr10_94673673_G_T | chr10:94673673 | 2,080 | 896 | 2,624 | — |
| chr10_94673811_T_C | chr10:94673811 | -2,080 | -656 | -2,112 | — |
| chr10_94673752_C_A | chr10:94673752 | 2,080 | 640 | 768 | — |
| chr10_94673762_A_C | chr10:94673762 | -1,984 | -768 | -1,088 | — |
| chr10_94673766_C_A | chr10:94673766 | -1,968 | -736 | -4,096 | — |
| chr10_94673730_T_G | chr10:94673730 | 1,952 | 816 | 4,288 | — |
| chr10_94673686_C_G | chr10:94673686 | 1,952 | 592 | 1,408 | — |
| chr10_94673727_A_C | chr10:94673727 | -1,920 | -672 | -1,920 | — |
| chr10_94673771_G_T | chr10:94673771 | -1,920 | -304 | -1,472 | — |
| chr10_94673728_C_G | chr10:94673728 | 1,904 | 704 | 2,176 | — |
| chr10_94673755_G_C | chr10:94673755 | -1,888 | -624 | 960 | — |
| chr10_94673765_G_T | chr10:94673765 | -1,856 | -400 | -2,624 | — |
| chr10_94673772_A_C | chr10:94673772 | -1,856 | -480 | -2,560 | — |
| chr10_94673663_T_G | chr10:94673663 | 1,856 | 624 | 1,792 | — |
| chr10_94673802_T_A | chr10:94673802 | -1,856 | -464 | -1,216 | — |
| chr10_94673707_A_G | chr10:94673707 | 1,840 | 784 | 2,496 | — |
| chr10_94673778_T_G | chr10:94673778 | -1,824 | -64 | -4,864 | — |
| chr10_94673833_C_G | chr10:94673833 | -1,824 | -432 | -1,920 | — |
| chr10_94673825_G_A | chr10:94673825 | 1,824 | 1,232 | -1,216 | — |
| chr10_94673772_A_T | chr10:94673772 | -1,792 | -256 | -3,712 | — |
| chr10_94673681_A_T | chr10:94673681 | -1,776 | -544 | -1,856 | — |
| chr10_94673705_T_C | chr10:94673705 | -1,776 | -704 | -1,728 | — |
| chr10_94673701_G_C | chr10:94673701 | -1,760 | -704 | -2,560 | — |
| chr10_94673786_G_A | chr10:94673786 | -1,760 | -256 | -1,920 | — |
| chr10_94673771_G_A | chr10:94673771 | -1,760 | 192 | -64 | — |
| chr10_94673747_T_A | chr10:94673747 | -1,744 | -960 | -384 | — |
| chr10_94673826_A_C | chr10:94673826 | -1,696 | -432 | -3,968 | — |
| chr10_94673775_A_G | chr10:94673775 | 1,664 | 1,600 | 11,072 | — |
| chr10_94673831_A_T | chr10:94673831 | -1,664 | -496 | -3,200 | — |
| chr10_94673749_G_T | chr10:94673749 | 1,616 | 912 | 2,304 | — |
| chr10_94673817_T_G | chr10:94673817 | 1,600 | 752 | 2,432 | — |
| chr10_94673754_A_G | chr10:94673754 | 1,504 | 480 | 3,456 | — |
| chr10_94673724_C_G | chr10:94673724 | -1,488 | -720 | -2,048 | — |
| chr10_94673714_A_T | chr10:94673714 | -1,488 | -576 | -1,856 | — |
| chr10_94673783_T_C | chr10:94673783 | 1,472 | 320 | 2,688 | — |
| chr10_94673743_C_T | chr10:94673743 | -1,456 | 256 | -2,624 | — |
| chr10_94673813_A_T | chr10:94673813 | 1,440 | 672 | 2,304 | — |
| chr10_94673679_C_T | chr10:94673679 | 1,408 | 448 | 1,792 | — |
| chr10_94673815_C_T | chr10:94673815 | 1,376 | 720 | 2,112 | — |
| chr10_94673679_C_A | chr10:94673679 | 1,360 | 496 | 2,112 | — |
| chr10_94673826_A_T | chr10:94673826 | -1,344 | -144 | -3,648 | — |
| chr10_94673828_T_G | chr10:94673828 | 1,344 | -768 | 3,392 | — |
| chr10_94707948_A_C | chr10:94707948 | 1,344 | 640 | 1,984 | 6.6e-6 |
| chr10_94673788_T_C | chr10:94673788 | -1,312 | 496 | -3,456 | 6.6e-6 |
| chr10_94673781_C_A | chr10:94673781 | -1,312 | -128 | -3,200 | — |
| chr10_94673792_A_T | chr10:94673792 | 1,280 | 1,184 | 2,304 | — |
| chr10_94673801_G_A | chr10:94673801 | -1,280 | -576 | -2,240 | — |
| chr10_94673697_G_A | chr10:94673697 | -1,264 | -656 | -1,920 | — |
| chr10_94673783_T_G | chr10:94673783 | -1,248 | -672 | -1,920 | — |
| chr10_94673754_A_C | chr10:94673754 | 1,232 | 336 | 2,048 | — |
| chr10_94673745_C_G | chr10:94673745 | 1,216 | 512 | 2,176 | — |
| chr10_94673789_G_C | chr10:94673789 | 1,184 | 1,344 | -2,688 | — |
| chr10_94673768_G_T | chr10:94673768 | -1,184 | -336 | -2,112 | — |
| chr10_94673827_C_T | chr10:94673827 | -1,184 | 0 | -2,048 | — |
| chr10_94673750_G_C | chr10:94673750 | -1,168 | -128 | 1,984 | — |
| chr10_94673817_T_C | chr10:94673817 | 1,056 | 512 | 1,984 | 1.3e-5 |
| chr10_94673786_G_T | chr10:94673786 | -1,056 | -224 | -1,920 | — |
| chr10_94673795_A_C | chr10:94673795 | -1,024 | 352 | -4,224 | — |
| chr10_94673765_G_A | chr10:94673765 | -992 | -400 | -2,048 | — |
| chr10_94673824_T_C | chr10:94673824 | -992 | -192 | -2,048 | 6.6e-6 |
| chr10_94673834_C_A | chr10:94673834 | -992 | -304 | -2,048 | — |
| chr10_94673827_C_G | chr10:94673827 | -992 | -32 | -1,984 | — |
| chr10_94673796_C_T | chr10:94673796 | 960 | 208 | 2,112 | 6.6e-6 |
| chr10_94673827_C_A | chr10:94673827 | -928 | 240 | -2,496 | — |
| chr10_94673795_A_T | chr10:94673795 | 896 | 960 | -2,944 | — |
| chr10_94673826_A_G | chr10:94673826 | -896 | 32 | -2,368 | — |
| chr10_94673719_A_G | chr10:94673719 | 880 | 384 | 2,176 | — |
| chr10_94673774_T_A | chr10:94673774 | -864 | -832 | -5,824 | — |
| chr10_94673710_A_T | chr10:94673710 | -848 | -384 | -2,112 | — |
| chr10_94673643_G_A | chr10:94673643 | -832 | -336 | -1,728 | 2.6e-5 |
| chr10_94673824_T_A | chr10:94673824 | -800 | 80 | -2,560 | — |
| chr10_94673782_C_A | chr10:94673782 | -736 | -400 | -3,712 | — |
| chr10_94673797_T_C | chr10:94673797 | 736 | 176 | 2,880 | — |
| chr10_94673813_A_G | chr10:94673813 | 704 | 240 | 3,456 | — |
| chr10_94673729_A_G | chr10:94673729 | 656 | 432 | 1,984 | — |
| chr10_94673832_C_A | chr10:94673832 | -576 | 80 | -2,432 | — |
| chr10_94673818_T_A | chr10:94673818 | 512 | 224 | 4,160 | — |
| chr10_94673782_C_T | chr10:94673782 | -512 | -272 | -2,240 | 6.6e-6 |
| chr10_94673740_C_T | chr10:94673740 | -464 | 192 | -2,112 | — |
| chr10_94673766_C_T | chr10:94673766 | -448 | -224 | -1,984 | — |
| chr10_94673674_A_C | chr10:94673674 | 432 | 304 | 1,728 | — |
| chr10_94673747_T_C | chr10:94673747 | 416 | -256 | 2,560 | — |
| chr10_94673730_T_C | chr10:94673730 | 416 | 272 | 2,112 | — |
| chr10_94673814_T_A | chr10:94673814 | -384 | 176 | 3,200 | 5.3e-5 |
| chr10_94673818_T_G | chr10:94673818 | -352 | 112 | 3,456 | — |
| chr10_94673825_G_C | chr10:94673825 | 352 | 640 | -1,792 | — |
| chr10_94673733_C_G | chr10:94673733 | 336 | 224 | 1,920 | — |
| chr10_94673747_T_G | chr10:94673747 | -272 | -544 | 1,920 | — |
| chr10_94673623_G_T | chr10:94673623 | -256 | -160 | -1,792 | — |
| chr10_94673669_A_G | chr10:94673669 | 192 | 224 | 1,728 | — |
| chr10_94673748_T_C | chr10:94673748 | 128 | -112 | 2,688 | — |
| chr10_94673788_T_G | chr10:94673788 | 96 | 1,248 | -3,520 | — |
| chr10_94673787_A_T | chr10:94673787 | 64 | 800 | -3,072 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.