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CYP2C8
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of CYP2C8 reduces the inducible metabolic clearance of substrates such as repaglinide and paclitaxel.
Affected substrate drugs (PharmGKB): ibuprofen; tacrolimus; rosiglitazone; pioglitazone; amodiaquine; paclitaxel
Scored variants near CYP2C8
chr10:94,936,771..95,169,497, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr10_94936934_T_A | chr10:94936934 | -66,240 | -24,192 | -29,760 | — |
| chr10_94936905_T_A | chr10:94936905 | -64,704 | -28,512 | -37,696 | — |
| chr10_94936924_C_A | chr10:94936924 | -61,216 | -27,264 | -37,504 | — |
| chr10_94936921_T_A | chr10:94936921 | -56,928 | -25,152 | -30,016 | — |
| chr10_94936924_C_T | chr10:94936924 | -56,096 | -24,832 | -32,960 | — |
| chr10_94936935_T_A | chr10:94936935 | -54,912 | -23,648 | -30,720 | — |
| chr10_94936937_C_A | chr10:94936937 | -53,984 | -21,856 | -28,480 | — |
| chr10_94936924_C_G | chr10:94936924 | -53,600 | -23,552 | -30,592 | — |
| chr10_94936910_T_A | chr10:94936910 | -53,376 | -19,520 | -23,488 | — |
| chr10_94936940_A_T | chr10:94936940 | -52,288 | -23,392 | -32,128 | — |
| chr10_94936897_A_G | chr10:94936897 | 52,160 | 14,144 | 17,024 | — |
| chr10_94936941_A_T | chr10:94936941 | -51,712 | -21,920 | -26,816 | — |
| chr10_94936916_A_T | chr10:94936916 | -51,072 | -23,200 | -29,504 | — |
| chr10_94936934_T_G | chr10:94936934 | -50,464 | -16,544 | -20,480 | — |
| chr10_94936935_T_C | chr10:94936935 | -49,792 | -21,408 | -26,432 | — |
| chr10_94936979_A_T | chr10:94936979 | -49,760 | -20,608 | -24,768 | — |
| chr10_94936934_T_C | chr10:94936934 | -49,568 | -16,672 | -20,096 | — |
| chr10_94936912_G_C | chr10:94936912 | -49,152 | -21,536 | -26,752 | 6.6e-6 |
| chr10_94936940_A_G | chr10:94936940 | -49,152 | -21,632 | -28,800 | — |
| chr10_94936939_A_G | chr10:94936939 | -48,768 | -21,376 | -28,288 | — |
| chr10_94936906_T_A | chr10:94936906 | -48,128 | -17,312 | -22,912 | — |
| chr10_94936913_A_G | chr10:94936913 | 46,848 | 11,520 | 16,896 | — |
| chr10_94936968_A_T | chr10:94936968 | -46,496 | -19,360 | -23,808 | — |
| chr10_94936913_A_T | chr10:94936913 | 45,952 | 11,072 | 16,256 | — |
| chr10_94936938_G_T | chr10:94936938 | -45,632 | -17,216 | -22,592 | — |
| chr10_94936948_A_G | chr10:94936948 | 45,440 | 11,328 | 18,176 | — |
| chr10_94936966_T_A | chr10:94936966 | -45,248 | -13,856 | -15,424 | — |
| chr10_94936898_T_C | chr10:94936898 | 45,056 | 10,752 | 14,720 | — |
| chr10_94936937_C_G | chr10:94936937 | -44,960 | -17,632 | -21,952 | — |
| chr10_94936969_A_T | chr10:94936969 | -44,928 | -17,088 | -20,288 | — |
| chr10_94936898_T_G | chr10:94936898 | 44,480 | 9,728 | 14,336 | — |
| chr10_94936923_A_T | chr10:94936923 | -43,904 | -19,104 | -23,040 | — |
| chr10_94936915_A_T | chr10:94936915 | -43,872 | -19,552 | -23,872 | — |
| chr10_94936941_A_C | chr10:94936941 | -43,744 | -18,464 | -21,568 | — |
| chr10_94936942_T_A | chr10:94936942 | -42,976 | -14,528 | -17,472 | — |
| chr10_94936889_T_A | chr10:94936889 | -42,880 | -19,424 | -22,272 | — |
| chr10_94936903_G_T | chr10:94936903 | -42,656 | -18,016 | -23,808 | 6.6e-6 |
| chr10_94936936_A_C | chr10:94936936 | -42,400 | -18,816 | -22,656 | — |
| chr10_94936937_C_T | chr10:94936937 | -41,568 | -16,480 | -20,480 | 6.9e-4 |
| chr10_94936912_G_T | chr10:94936912 | -41,472 | -17,856 | -22,848 | 6.6e-6 |
| chr10_94936899_T_C | chr10:94936899 | 41,216 | 11,104 | 15,680 | — |
| chr10_94936909_T_A | chr10:94936909 | -41,056 | -16,928 | -20,224 | — |
| chr10_94936938_G_C | chr10:94936938 | -39,968 | -14,528 | -18,816 | — |
| chr10_94936968_A_G | chr10:94936968 | -39,424 | -15,776 | -19,328 | — |
| chr10_94936910_T_G | chr10:94936910 | -39,232 | -12,704 | -14,528 | — |
| chr10_94936908_T_C | chr10:94936908 | 38,912 | 11,904 | 15,488 | — |
| chr10_94936979_A_G | chr10:94936979 | -38,784 | -15,104 | -17,088 | 6.6e-6 |
| chr10_94936966_T_G | chr10:94936966 | -38,144 | -11,264 | -11,392 | — |
| chr10_94936897_A_C | chr10:94936897 | 37,760 | 9,216 | 12,928 | — |
| chr10_94936933_A_T | chr10:94936933 | -37,568 | -15,040 | -17,792 | — |
| chr10_94936969_A_G | chr10:94936969 | -37,184 | -14,080 | -15,872 | — |
| chr10_94936969_A_C | chr10:94936969 | -37,056 | -13,888 | -16,192 | — |
| chr10_94936938_G_A | chr10:94936938 | -36,800 | -12,864 | -16,704 | 3.9e-4 |
| chr10_94936900_A_C | chr10:94936900 | 36,608 | 10,880 | 12,800 | — |
| chr10_94936916_A_G | chr10:94936916 | -36,480 | -16,096 | -18,112 | — |
| chr10_94936950_C_T | chr10:94936950 | -36,480 | -11,104 | -13,632 | 6.6e-6 |
| chr10_94936890_T_A | chr10:94936890 | -36,160 | -15,072 | -16,896 | — |
| chr10_94936923_A_C | chr10:94936923 | -36,160 | -15,488 | -16,768 | 2.0e-5 |
| chr10_94936909_T_G | chr10:94936909 | -35,840 | -14,048 | -16,256 | — |
| chr10_94936890_T_G | chr10:94936890 | -35,712 | -15,616 | -16,704 | — |
| chr10_94936970_T_A | chr10:94936970 | -35,552 | -11,520 | -13,632 | — |
| chr10_94936971_A_T | chr10:94936971 | -35,552 | -14,048 | -17,024 | — |
| chr10_94936941_A_G | chr10:94936941 | -35,488 | -14,368 | -16,896 | — |
| chr10_94936967_A_G | chr10:94936967 | -35,392 | -14,112 | -16,128 | — |
| chr10_94936950_C_A | chr10:94936950 | -35,008 | -10,208 | -12,992 | — |
| chr10_94936892_A_T | chr10:94936892 | -34,496 | -15,616 | -19,072 | — |
| chr10_94936965_G_T | chr10:94936965 | -34,496 | -12,640 | -15,232 | — |
| chr10_94936899_T_G | chr10:94936899 | 34,368 | 9,120 | 13,120 | — |
| chr10_94936965_G_A | chr10:94936965 | -33,888 | -13,632 | -15,104 | — |
| chr10_94936967_A_T | chr10:94936967 | -33,696 | -13,056 | -15,040 | — |
| chr10_94936921_T_G | chr10:94936921 | -33,344 | -15,040 | -14,400 | — |
| chr10_94936918_A_C | chr10:94936918 | 33,088 | 8,384 | 10,752 | — |
| chr10_94936920_T_A | chr10:94936920 | -32,448 | -13,952 | -14,976 | — |
| chr10_94936925_T_G | chr10:94936925 | -32,192 | -14,208 | -13,056 | — |
| chr10_94936915_A_C | chr10:94936915 | -32,064 | -14,432 | -14,784 | — |
| chr10_94936965_G_C | chr10:94936965 | -32,032 | -11,456 | -13,312 | — |
| chr10_94936893_T_G | chr10:94936893 | -31,744 | -14,016 | -14,208 | — |
| chr10_94936931_G_T | chr10:94936931 | -31,680 | -12,992 | -15,616 | — |
| chr10_94936948_A_C | chr10:94936948 | 31,232 | 7,488 | 11,392 | — |
| chr10_94936884_A_C | chr10:94936884 | -30,656 | -14,720 | -16,512 | — |
| chr10_94936927_G_T | chr10:94936927 | -30,656 | -12,448 | -14,720 | — |
| chr10_94936884_A_T | chr10:94936884 | -30,272 | -14,432 | -17,088 | — |
| chr10_94936887_T_G | chr10:94936887 | 30,272 | 9,504 | 11,136 | — |
| chr10_94936959_C_T | chr10:94936959 | -30,144 | -11,072 | -13,056 | — |
| chr10_94936904_T_C | chr10:94936904 | -29,632 | -9,760 | -13,440 | — |
| chr10_94936893_T_C | chr10:94936893 | 29,376 | 9,344 | 10,880 | — |
| chr10_94936918_A_G | chr10:94936918 | 28,928 | 5,568 | 9,472 | — |
| chr10_94936922_T_A | chr10:94936922 | 28,928 | 7,456 | 10,112 | — |
| chr10_94936917_T_A | chr10:94936917 | -28,864 | -12,320 | -13,376 | — |
| chr10_94936923_A_G | chr10:94936923 | -28,288 | -12,064 | -11,968 | — |
| chr10_94936968_A_C | chr10:94936968 | -28,256 | -10,560 | -12,352 | — |
| chr10_94936913_A_C | chr10:94936913 | 28,032 | 8,000 | 11,392 | — |
| chr10_94936891_A_T | chr10:94936891 | -27,264 | -13,120 | -14,336 | — |
| chr10_94937022_A_C | chr10:94937022 | 27,264 | 8,416 | 6,720 | — |
| chr10_94936972_T_A | chr10:94936972 | -26,912 | -11,264 | -12,480 | — |
| chr10_94936895_A_T | chr10:94936895 | -26,496 | -10,784 | -12,352 | — |
| chr10_94936976_T_G | chr10:94936976 | -26,336 | -9,728 | -10,688 | — |
| chr10_94936892_A_G | chr10:94936892 | -26,048 | -11,360 | -12,416 | — |
| chr10_94936839_A_G | chr10:94936839 | 25,856 | 8,864 | 9,664 | 6.6e-6 |
| chr10_94936888_A_T | chr10:94936888 | -25,792 | -11,968 | -14,080 | — |
| chr10_94936925_T_A | chr10:94936925 | -25,472 | -10,368 | -10,368 | — |
| chr10_94936894_G_T | chr10:94936894 | -25,152 | -8,224 | -10,944 | — |
| chr10_94936883_T_A | chr10:94936883 | -25,088 | -11,520 | -12,928 | — |
| chr10_94936970_T_G | chr10:94936970 | -24,960 | -7,520 | -8,768 | — |
| chr10_94936903_G_A | chr10:94936903 | -24,832 | -11,008 | -13,760 | 1.3e-5 |
| chr10_94936905_T_C | chr10:94936905 | -24,704 | -7,424 | -10,048 | 3.9e-5 |
| chr10_94936889_T_C | chr10:94936889 | -24,064 | -11,488 | -10,816 | — |
| chr10_94936893_T_A | chr10:94936893 | -23,936 | -10,560 | -11,776 | — |
| chr10_94936971_A_G | chr10:94936971 | -23,872 | -8,896 | -10,176 | — |
| chr10_94936914_A_C | chr10:94936914 | 23,616 | 6,208 | 8,704 | — |
| chr10_94936884_A_G | chr10:94936884 | -23,552 | -11,392 | -12,096 | — |
| chr10_94936912_G_A | chr10:94936912 | -23,424 | -9,792 | -12,416 | — |
| chr10_94936960_T_G | chr10:94936960 | 23,424 | 5,472 | 9,152 | — |
| chr10_94936906_T_C | chr10:94936906 | -23,232 | -5,984 | -8,512 | — |
| chr10_94936971_A_C | chr10:94936971 | -23,136 | -9,120 | -10,112 | — |
| chr10_94936892_A_C | chr10:94936892 | -23,104 | -10,912 | -11,328 | — |
| chr10_94936883_T_G | chr10:94936883 | -22,912 | -10,848 | -11,584 | — |
| chr10_94936916_A_C | chr10:94936916 | -22,912 | -9,216 | -9,536 | — |
| chr10_94936883_T_C | chr10:94936883 | -22,784 | -10,496 | -11,008 | — |
| chr10_94936984_A_C | chr10:94936984 | -22,784 | -7,808 | -8,704 | — |
| chr10_94936897_A_T | chr10:94936897 | 22,656 | 5,120 | 7,040 | — |
| chr10_94936890_T_C | chr10:94936890 | -22,592 | -10,208 | -8,896 | — |
| chr10_94936886_T_G | chr10:94936886 | -22,336 | -9,376 | -8,960 | — |
| chr10_94937038_T_C | chr10:94937038 | 22,272 | 6,624 | 5,888 | — |
| chr10_94936973_T_C | chr10:94936973 | -21,696 | -7,360 | -8,256 | — |
| chr10_94936888_A_C | chr10:94936888 | -21,632 | -10,880 | -11,776 | — |
| chr10_94936821_C_G | chr10:94936821 | 21,568 | 6,112 | 7,296 | — |
| chr10_94936974_G_T | chr10:94936974 | 21,440 | 4,512 | 6,272 | — |
| chr10_94936885_A_G | chr10:94936885 | -21,376 | -10,400 | -9,600 | — |
| chr10_94936891_A_C | chr10:94936891 | -21,312 | -10,880 | -10,560 | — |
| chr10_94936881_T_C | chr10:94936881 | -21,056 | -9,536 | -8,640 | — |
| chr10_94936983_A_C | chr10:94936983 | -21,056 | -7,360 | -7,808 | — |
| chr10_94936894_G_A | chr10:94936894 | -20,992 | -7,616 | -9,792 | — |
| chr10_94936931_G_A | chr10:94936931 | -20,960 | -8,352 | -9,984 | — |
| chr10_94936904_T_G | chr10:94936904 | -20,928 | -5,152 | -8,768 | — |
| chr10_94936929_C_T | chr10:94936929 | -20,864 | -8,064 | -9,152 | 1.3e-5 |
| chr10_94936951_A_T | chr10:94936951 | 20,736 | 8,256 | 6,784 | — |
| chr10_94936895_A_C | chr10:94936895 | -20,672 | -8,512 | -7,488 | — |
| chr10_94936957_C_T | chr10:94936957 | -20,608 | -8,416 | -9,216 | — |
| chr10_94936917_T_C | chr10:94936917 | -20,416 | -9,504 | -7,808 | 1.6e-2 |
| chr10_94936926_A_G | chr10:94936926 | -20,352 | -6,816 | -6,784 | — |
| chr10_94937011_A_T | chr10:94937011 | 20,352 | 7,744 | 5,504 | — |
| chr10_94936915_A_G | chr10:94936915 | -20,288 | -8,384 | -8,320 | — |
| chr10_94936889_T_G | chr10:94936889 | -20,160 | -8,480 | -8,832 | — |
| chr10_94936901_A_C | chr10:94936901 | 20,096 | 6,144 | 7,552 | — |
| chr10_94936887_T_C | chr10:94936887 | 20,032 | 7,456 | 8,448 | — |
| chr10_94936838_T_C | chr10:94936838 | 19,712 | 6,272 | 5,248 | — |
| chr10_94936900_A_G | chr10:94936900 | 19,328 | 6,080 | 7,424 | — |
| chr10_94936858_C_A | chr10:94936858 | -19,264 | -7,392 | -7,936 | — |
| chr10_94936902_T_C | chr10:94936902 | -19,200 | -3,584 | -6,144 | — |
| chr10_94936877_G_A | chr10:94936877 | -19,008 | -7,040 | -8,128 | — |
| chr10_94936882_G_T | chr10:94936882 | 19,008 | 5,184 | 6,016 | 6.6e-6 |
| chr10_94937035_G_C | chr10:94937035 | 18,944 | 6,112 | 7,744 | — |
| chr10_94936946_G_A | chr10:94936946 | -18,560 | -4,928 | -6,976 | — |
| chr10_94936854_T_A | chr10:94936854 | -18,496 | -6,176 | -6,784 | 6.6e-6 |
| chr10_94936911_T_C | chr10:94936911 | -18,496 | -6,016 | -6,592 | — |
| chr10_94937039_T_A | chr10:94937039 | 18,496 | 6,688 | 4,992 | — |
| chr10_94936929_C_A | chr10:94936929 | -18,304 | -6,592 | -7,616 | — |
| chr10_94936855_G_C | chr10:94936855 | -17,984 | -6,816 | -7,808 | — |
| chr10_94936902_T_G | chr10:94936902 | -17,856 | -3,072 | -6,016 | — |
| chr10_94936888_A_G | chr10:94936888 | -17,792 | -8,960 | -9,088 | — |
| chr10_94936903_G_C | chr10:94936903 | -17,792 | -6,016 | -7,872 | — |
| chr10_94936967_A_C | chr10:94936967 | -17,696 | -7,168 | -7,488 | — |
| chr10_94936914_A_T | chr10:94936914 | 17,600 | 3,776 | 6,400 | — |
| chr10_94936946_G_C | chr10:94936946 | -17,536 | -4,768 | -7,040 | — |
| chr10_94936854_T_G | chr10:94936854 | -17,408 | -5,504 | -6,016 | — |
| chr10_94936882_G_C | chr10:94936882 | -17,344 | -5,984 | -6,400 | — |
| chr10_94936858_C_T | chr10:94936858 | -16,960 | -6,016 | -6,784 | — |
| chr10_94936882_G_A | chr10:94936882 | -16,896 | -6,816 | -6,976 | — |
| chr10_94936964_A_C | chr10:94936964 | -16,864 | -6,080 | -7,040 | — |
| chr10_94936947_A_T | chr10:94936947 | -16,800 | -6,080 | -7,872 | — |
| chr10_94936907_A_T | chr10:94936907 | -16,768 | -4,576 | -8,064 | — |
| chr10_94936911_T_A | chr10:94936911 | 16,704 | 6,144 | 6,144 | — |
| chr10_94936954_G_T | chr10:94936954 | -16,576 | -4,672 | -5,632 | 6.6e-6 |
| chr10_94936885_A_T | chr10:94936885 | -16,512 | -8,928 | -7,552 | — |
| chr10_94936896_A_G | chr10:94936896 | 16,512 | 5,376 | 6,656 | — |
| chr10_94936977_G_T | chr10:94936977 | 16,128 | 4,032 | 4,288 | — |
| chr10_94936886_T_C | chr10:94936886 | -16,064 | -6,656 | -5,376 | — |
| chr10_94936899_T_A | chr10:94936899 | 16,000 | 3,744 | 5,760 | — |
| chr10_94936998_T_A | chr10:94936998 | -16,000 | -6,080 | -5,504 | — |
| chr10_94936996_G_C | chr10:94936996 | -15,936 | -6,080 | -6,336 | — |
| chr10_94937045_C_G | chr10:94937045 | 15,936 | 5,216 | 5,120 | — |
| chr10_94936920_T_C | chr10:94936920 | -15,808 | -7,776 | -6,336 | — |
| chr10_94936874_C_A | chr10:94936874 | -15,744 | -5,408 | -6,144 | — |
| chr10_94936946_G_T | chr10:94936946 | -15,680 | -4,000 | -5,952 | — |
| chr10_94936974_G_C | chr10:94936974 | -15,680 | -4,320 | -4,608 | — |
| chr10_94937041_T_G | chr10:94937041 | -15,616 | -6,592 | -5,312 | — |
| chr10_94936931_G_C | chr10:94936931 | -15,488 | -5,728 | -6,976 | — |
| chr10_94936963_C_T | chr10:94936963 | -15,488 | -5,376 | -6,144 | — |
| chr10_94936879_G_T | chr10:94936879 | 15,360 | 5,504 | 6,208 | — |
| chr10_94937012_A_G | chr10:94937012 | 15,296 | 5,792 | 4,352 | — |
| chr10_94936947_A_C | chr10:94936947 | -15,264 | -5,152 | -6,848 | — |
| chr10_94936887_T_A | chr10:94936887 | -15,232 | -5,664 | -7,104 | — |
| chr10_94936817_T_C | chr10:94936817 | 15,168 | 5,088 | 5,248 | — |
| chr10_94936874_C_T | chr10:94936874 | -15,168 | -5,504 | -5,760 | 6.6e-6 |
| chr10_94936910_T_C | chr10:94936910 | 15,168 | 4,736 | 5,760 | — |
| chr10_94936961_A_C | chr10:94936961 | 15,104 | 3,552 | 4,992 | — |
| chr10_94936979_A_C | chr10:94936979 | -15,040 | -5,024 | -5,184 | — |
| chr10_94936904_T_A | chr10:94936904 | -14,976 | -3,840 | -6,464 | — |
| chr10_94936954_G_A | chr10:94936954 | -14,848 | -3,936 | -5,120 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.