Home / Gene
CYP3A4
receptor: PXRTier 1
CAMIP causal chains
PXR
CYP3A subfamily enzymes metabolize ~30% of clinically used drugs. Blunted receptor-mediated induction of CYP3A4 reduces its inducible metabolic capacity under PXR inducers.
Drug context: quetiapine; tacrolimus; fentanyl; cyclosporine; sufentanil; simvastatin
Scored variants near CYP3A4
chr7:99,656,966..99,884,184, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr7_99680060_C_A | chr7:99680060 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680041_G_T | chr7:99680041 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680061_C_T | chr7:99680061 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680063_A_T | chr7:99680063 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680062_A_C | chr7:99680062 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680061_C_A | chr7:99680061 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680062_A_T | chr7:99680062 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680048_C_G | chr7:99680048 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680041_G_A | chr7:99680041 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680060_C_G | chr7:99680060 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680041_G_C | chr7:99680041 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680060_C_T | chr7:99680060 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680042_G_T | chr7:99680042 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680061_C_G | chr7:99680061 | -1.000 | -1.000 | -0.988 | — |
| chr7_99680063_A_C | chr7:99680063 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680063_A_G | chr7:99680063 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680042_G_A | chr7:99680042 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680045_G_A | chr7:99680045 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680062_A_G | chr7:99680062 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680040_A_T | chr7:99680040 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680046_G_C | chr7:99680046 | -1.000 | -1.000 | -0.953 | — |
| chr7_99671516_G_C | chr7:99671516 | 1.000 | 1.000 | 1.000 | — |
| chr7_99680066_G_T | chr7:99680066 | -1.000 | -1.000 | -1.000 | — |
| chr7_99680081_C_G | chr7:99680081 | -1.000 | -0.805 | -1.000 | — |
| chr7_99680040_A_C | chr7:99680040 | -1.000 | -1.000 | -0.865 | — |
| chr7_99671533_T_A | chr7:99671533 | 1.000 | 1.000 | 1.000 | — |
| chr7_99680023_T_G | chr7:99680023 | -1.000 | -0.728 | -1.000 | — |
| chr7_99680011_C_A | chr7:99680011 | -1.000 | -0.858 | -1.000 | — |
| chr7_99680042_G_C | chr7:99680042 | -1.000 | -0.939 | -0.859 | — |
| chr7_99680064_T_A | chr7:99680064 | -1.000 | -0.865 | -0.771 | — |
| chr7_99680064_T_G | chr7:99680064 | -1.000 | -0.931 | -0.841 | — |
| chr7_99680058_A_C | chr7:99680058 | -1.000 | -0.901 | -0.753 | — |
| chr7_99680045_G_C | chr7:99680045 | -1.000 | -0.670 | -0.676 | — |
| chr7_99680023_T_A | chr7:99680023 | -1.000 | -0.602 | -0.941 | — |
| chr7_99671585_A_G | chr7:99671585 | 1.000 | 0.784 | 0.844 | — |
| chr7_99679979_T_A | chr7:99679979 | -1.000 | -0.586 | -0.771 | — |
| chr7_99680048_C_A | chr7:99680048 | -0.957 | -0.680 | -0.824 | — |
| chr7_99680064_T_C | chr7:99680064 | -0.942 | -0.779 | -0.706 | — |
| chr7_99680081_C_T | chr7:99680081 | -0.935 | -0.602 | -0.718 | — |
| chr7_99679973_T_A | chr7:99679973 | 0.902 | 0.185 | 0.935 | — |
| chr7_99680009_A_T | chr7:99680009 | -0.892 | -0.528 | -0.541 | — |
| chr7_99680059_G_T | chr7:99680059 | -0.857 | -0.561 | -0.606 | — |
| chr7_99680030_C_A | chr7:99680030 | -0.855 | -0.561 | -0.694 | — |
| chr7_99680047_G_C | chr7:99680047 | -0.849 | -0.477 | -0.594 | — |
| chr7_99679981_C_A | chr7:99679981 | 0.842 | 0.792 | 0.394 | — |
| chr7_99680010_G_T | chr7:99680010 | -0.832 | -0.256 | -0.553 | — |
| chr7_99680039_G_C | chr7:99680039 | -0.825 | -0.599 | -0.624 | — |
| chr7_99680059_G_C | chr7:99680059 | -0.819 | -0.538 | -0.541 | — |
| chr7_99680045_G_T | chr7:99680045 | -0.812 | -0.459 | -0.559 | — |
| chr7_99680006_C_A | chr7:99680006 | -0.789 | -0.462 | -0.553 | — |
| chr7_99680083_C_T | chr7:99680083 | -0.787 | -0.594 | -0.629 | — |
| chr7_99671585_A_T | chr7:99671585 | 0.785 | 0.561 | 0.615 | — |
| chr7_99679970_G_T | chr7:99679970 | -0.785 | -0.325 | -0.506 | — |
| chr7_99679971_C_T | chr7:99679971 | -0.785 | -0.274 | -0.624 | — |
| chr7_99680046_G_A | chr7:99680046 | -0.779 | -0.574 | -0.594 | — |
| chr7_99680046_G_T | chr7:99680046 | -0.770 | -0.556 | -0.594 | — |
| chr7_99679995_G_T | chr7:99679995 | -0.769 | -0.332 | -0.512 | — |
| chr7_99679997_A_T | chr7:99679997 | -0.752 | -0.510 | -0.382 | — |
| chr7_99679971_C_A | chr7:99679971 | -0.745 | -0.216 | -0.535 | — |
| chr7_99680006_C_T | chr7:99680006 | -0.722 | -0.365 | -0.506 | — |
| chr7_99680043_C_A | chr7:99680043 | -0.722 | -0.500 | -0.553 | — |
| chr7_99679970_G_C | chr7:99679970 | -0.719 | -0.302 | -0.476 | — |
| chr7_99680071_G_C | chr7:99680071 | 0.707 | 0.416 | 0.329 | — |
| chr7_99680007_C_A | chr7:99680007 | -0.699 | -0.327 | -0.482 | — |
| chr7_99680038_G_T | chr7:99680038 | -0.697 | -0.528 | -0.547 | — |
| chr7_99680043_C_G | chr7:99680043 | -0.697 | -0.477 | -0.494 | — |
| chr7_99671516_G_T | chr7:99671516 | 0.692 | 0.734 | 0.621 | — |
| chr7_99679972_C_A | chr7:99679972 | -0.679 | -0.173 | -0.500 | — |
| chr7_99679973_T_C | chr7:99679973 | 0.679 | 0.119 | 0.794 | — |
| chr7_99680043_C_T | chr7:99680043 | -0.674 | -0.429 | -0.488 | — |
| chr7_99680058_A_T | chr7:99680058 | -0.674 | -0.599 | -0.482 | — |
| chr7_99671593_A_T | chr7:99671593 | 0.671 | 0.695 | 0.641 | — |
| chr7_99671577_C_T | chr7:99671577 | 0.669 | 0.520 | 0.553 | — |
| chr7_99679964_C_G | chr7:99679964 | -0.652 | -0.201 | -0.529 | — |
| chr7_99680005_G_A | chr7:99680005 | -0.642 | -0.206 | -0.459 | — |
| chr7_99671485_A_G | chr7:99671485 | 0.639 | 0.596 | 0.509 | — |
| chr7_99671575_T_G | chr7:99671575 | 0.636 | 0.637 | 0.721 | — |
| chr7_99680026_T_G | chr7:99680026 | -0.624 | -0.401 | -0.571 | — |
| chr7_99680076_G_C | chr7:99680076 | -0.624 | -0.393 | -0.624 | — |
| chr7_99680066_G_C | chr7:99680066 | -0.621 | -0.533 | -0.559 | — |
| chr7_99680038_G_C | chr7:99680038 | -0.619 | -0.515 | -0.429 | — |
| chr7_99680007_C_T | chr7:99680007 | -0.602 | -0.345 | -0.382 | — |
| chr7_99671569_A_G | chr7:99671569 | 0.596 | 0.558 | 0.574 | — |
| chr7_99680005_G_C | chr7:99680005 | -0.596 | -0.168 | -0.500 | — |
| chr7_99680005_G_T | chr7:99680005 | -0.592 | -0.228 | -0.400 | — |
| chr7_99680081_C_A | chr7:99680081 | -0.592 | -0.419 | -0.500 | — |
| chr7_99679996_C_A | chr7:99679996 | -0.582 | -0.231 | -0.441 | — |
| chr7_99680080_A_C | chr7:99680080 | -0.577 | -0.345 | -0.547 | — |
| chr7_99680008_A_C | chr7:99680008 | -0.569 | -0.388 | -0.418 | — |
| chr7_99680003_C_A | chr7:99680003 | -0.549 | -0.320 | -0.412 | — |
| chr7_99679972_C_G | chr7:99679972 | -0.546 | -0.160 | -0.353 | — |
| chr7_99680079_C_T | chr7:99680079 | -0.539 | -0.348 | -0.441 | — |
| chr7_99680084_C_T | chr7:99680084 | -0.537 | -0.459 | -0.400 | — |
| chr7_99671575_T_A | chr7:99671575 | 0.534 | 0.462 | 0.532 | — |
| chr7_99679963_G_T | chr7:99679963 | -0.532 | -0.150 | -0.429 | — |
| chr7_99679981_C_G | chr7:99679981 | 0.522 | 0.335 | 0.341 | — |
| chr7_99680079_C_G | chr7:99680079 | -0.521 | -0.325 | -0.441 | — |
| chr7_99680007_C_G | chr7:99680007 | -0.516 | -0.203 | -0.194 | — |
| chr7_99679978_C_T | chr7:99679978 | 0.512 | 0.284 | 0.312 | — |
| chr7_99680054_C_A | chr7:99680054 | -0.511 | -0.315 | -0.412 | — |
| chr7_99679972_C_T | chr7:99679972 | -0.506 | -0.114 | -0.435 | — |
| chr7_99680006_C_G | chr7:99680006 | -0.506 | -0.307 | -0.335 | — |
| chr7_99680048_C_T | chr7:99680048 | -0.506 | -0.317 | -0.465 | — |
| chr7_99679963_G_C | chr7:99679963 | -0.502 | -0.195 | -0.359 | — |
| chr7_99680047_G_T | chr7:99680047 | -0.502 | -0.244 | -0.441 | — |
| chr7_99680027_G_T | chr7:99680027 | 0.489 | 0.414 | 0.224 | — |
| chr7_99671574_A_G | chr7:99671574 | 0.484 | 0.421 | 0.456 | — |
| chr7_99671553_T_G | chr7:99671553 | -0.474 | -0.490 | -0.515 | — |
| chr7_99679969_T_A | chr7:99679969 | -0.469 | -0.140 | -0.359 | — |
| chr7_99680085_C_A | chr7:99680085 | -0.461 | -0.317 | -0.365 | — |
| chr7_99679963_G_A | chr7:99679963 | -0.456 | -0.117 | -0.429 | — |
| chr7_99671553_T_A | chr7:99671553 | -0.454 | -0.470 | -0.497 | — |
| chr7_99679964_C_T | chr7:99679964 | -0.453 | -0.096 | -0.406 | — |
| chr7_99680059_G_A | chr7:99680059 | -0.453 | -0.251 | -0.306 | — |
| chr7_99679983_C_G | chr7:99679983 | 0.449 | 0.459 | 0.465 | — |
| chr7_99680080_A_T | chr7:99680080 | -0.448 | -0.254 | -0.447 | — |
| chr7_99680082_A_C | chr7:99680082 | -0.439 | -0.363 | -0.465 | — |
| chr7_99679974_G_T | chr7:99679974 | -0.436 | -0.145 | -0.376 | — |
| chr7_99671570_A_T | chr7:99671570 | 0.429 | 0.322 | 0.362 | — |
| chr7_99680009_A_C | chr7:99680009 | -0.429 | -0.216 | -0.118 | — |
| chr7_99679999_T_A | chr7:99679999 | 0.426 | 0.282 | 0.282 | — |
| chr7_99680021_A_G | chr7:99680021 | 0.426 | 0.338 | 0.041 | — |
| chr7_99671533_T_G | chr7:99671533 | 0.424 | 0.431 | 0.429 | — |
| chr7_99679985_G_T | chr7:99679985 | -0.419 | -0.241 | -0.194 | — |
| chr7_99680027_G_C | chr7:99680027 | 0.419 | 0.317 | 0.006 | — |
| chr7_99680023_T_C | chr7:99680023 | -0.414 | -0.221 | -0.459 | — |
| chr7_99680058_A_G | chr7:99680058 | -0.413 | -0.383 | -0.300 | — |
| chr7_99679989_T_G | chr7:99679989 | 0.409 | 0.091 | 0.371 | — |
| chr7_99671568_T_G | chr7:99671568 | 0.404 | 0.454 | 0.406 | — |
| chr7_99671569_A_C | chr7:99671569 | 0.404 | 0.411 | 0.394 | — |
| chr7_99680067_C_T | chr7:99680067 | -0.403 | -0.251 | -0.318 | — |
| chr7_99680085_C_T | chr7:99680085 | -0.401 | -0.236 | -0.294 | — |
| chr7_99679969_T_G | chr7:99679969 | -0.399 | -0.096 | -0.347 | — |
| chr7_99671485_A_T | chr7:99671485 | 0.398 | 0.376 | 0.318 | — |
| chr7_99671577_C_G | chr7:99671577 | -0.398 | -0.376 | -0.438 | — |
| chr7_99671593_A_C | chr7:99671593 | 0.396 | 0.355 | 0.385 | — |
| chr7_99679970_G_A | chr7:99679970 | -0.393 | 0.086 | -0.271 | — |
| chr7_99679974_G_C | chr7:99679974 | -0.393 | -0.150 | -0.153 | — |
| chr7_99679964_C_A | chr7:99679964 | -0.389 | -0.117 | -0.376 | — |
| chr7_99679982_C_G | chr7:99679982 | 0.389 | 0.305 | 0.265 | — |
| chr7_99680052_A_C | chr7:99680052 | 0.388 | 0.145 | 0.235 | — |
| chr7_99679969_T_C | chr7:99679969 | -0.386 | -0.127 | -0.188 | — |
| chr7_99671516_G_A | chr7:99671516 | 0.384 | 0.426 | 0.344 | — |
| chr7_99680085_C_G | chr7:99680085 | -0.378 | -0.307 | -0.165 | — |
| chr7_99680020_G_A | chr7:99680020 | -0.373 | -0.223 | -0.429 | — |
| chr7_99671577_C_A | chr7:99671577 | -0.369 | -0.343 | -0.421 | — |
| chr7_99680029_G_T | chr7:99680029 | -0.369 | -0.157 | -0.294 | — |
| chr7_99680037_A_T | chr7:99680037 | -0.366 | -0.206 | -0.306 | — |
| chr7_99680039_G_A | chr7:99680039 | -0.366 | -0.211 | -0.341 | — |
| chr7_99671520_A_C | chr7:99671520 | 0.363 | 0.388 | 0.412 | — |
| chr7_99679971_C_G | chr7:99679971 | -0.363 | -0.058 | -0.276 | — |
| chr7_99679986_C_A | chr7:99679986 | 0.359 | 0.312 | 0.106 | — |
| chr7_99679988_C_G | chr7:99679988 | 0.333 | 0.228 | 0.629 | — |
| chr7_99680008_A_G | chr7:99680008 | -0.356 | -0.170 | -0.112 | — |
| chr7_99680057_C_A | chr7:99680057 | -0.354 | -0.264 | -0.318 | — |
| chr7_99680031_T_A | chr7:99680031 | -0.349 | -0.201 | -0.300 | — |
| chr7_99680079_C_A | chr7:99680079 | -0.349 | -0.223 | -0.335 | — |
| chr7_99679977_G_A | chr7:99679977 | 0.346 | 0.183 | 0.247 | — |
| chr7_99680052_A_T | chr7:99680052 | 0.344 | 0.188 | 0.224 | — |
| chr7_99680076_G_T | chr7:99680076 | -0.344 | -0.175 | -0.341 | — |
| chr7_99671564_C_T | chr7:99671564 | 0.338 | 0.429 | 0.326 | — |
| chr7_99679999_T_G | chr7:99679999 | 0.336 | 0.203 | 0.512 | — |
| chr7_99671549_A_C | chr7:99671549 | -0.328 | -0.343 | -0.347 | — |
| chr7_99680044_A_C | chr7:99680044 | -0.328 | -0.190 | -0.265 | — |
| chr7_99679995_G_A | chr7:99679995 | -0.326 | -0.157 | -0.229 | — |
| chr7_99679974_G_A | chr7:99679974 | 0.323 | 0.236 | 0.029 | — |
| chr7_99680050_A_T | chr7:99680050 | 0.323 | 0.226 | 0.329 | — |
| chr7_99680051_T_G | chr7:99680051 | 0.323 | 0.145 | 0.229 | — |
| chr7_99671481_T_G | chr7:99671481 | 0.321 | 0.246 | 0.256 | — |
| chr7_99671547_T_A | chr7:99671547 | -0.321 | -0.335 | -0.397 | — |
| chr7_99680001_T_G | chr7:99680001 | 0.319 | 0.129 | 0.459 | — |
| chr7_99679984_T_C | chr7:99679984 | -0.316 | -0.307 | -0.035 | — |
| chr7_99671547_T_G | chr7:99671547 | -0.314 | -0.340 | -0.368 | — |
| chr7_99671555_G_C | chr7:99671555 | -0.311 | -0.322 | -0.371 | — |
| chr7_99680034_A_C | chr7:99680034 | 0.309 | 0.122 | 0.329 | — |
| chr7_99680019_A_G | chr7:99680019 | -0.306 | -0.190 | -0.335 | — |
| chr7_99680024_T_A | chr7:99680024 | 0.306 | 0.251 | 0.147 | — |
| chr7_99671553_T_C | chr7:99671553 | -0.304 | -0.317 | -0.356 | — |
| chr7_99671581_T_A | chr7:99671581 | -0.304 | -0.294 | -0.315 | — |
| chr7_99671555_G_A | chr7:99671555 | -0.303 | -0.315 | -0.374 | — |
| chr7_99680068_A_T | chr7:99680068 | -0.301 | -0.322 | -0.271 | — |
| chr7_99680019_A_T | chr7:99680019 | 0.300 | 0.284 | 0.259 | — |
| chr7_99671549_A_T | chr7:99671549 | -0.298 | -0.325 | -0.341 | — |
| chr7_99671570_A_G | chr7:99671570 | 0.298 | 0.269 | 0.268 | — |
| chr7_99671555_G_T | chr7:99671555 | -0.296 | -0.310 | -0.371 | — |
| chr7_99680010_G_C | chr7:99680010 | -0.296 | 0.041 | -0.247 | — |
| chr7_99680012_T_A | chr7:99680012 | -0.293 | -0.175 | -0.241 | — |
| chr7_99680016_G_T | chr7:99680016 | -0.293 | -0.157 | -0.353 | — |
| chr7_99671579_A_T | chr7:99671579 | -0.291 | -0.302 | -0.326 | — |
| chr7_99680080_A_G | chr7:99680080 | -0.290 | -0.170 | -0.200 | — |
| chr7_99671579_A_G | chr7:99671579 | -0.286 | -0.292 | -0.324 | — |
| chr7_99680011_C_G | chr7:99680011 | 0.286 | -0.195 | -0.224 | — |
| chr7_99680055_T_A | chr7:99680055 | 0.286 | 0.188 | 0.194 | — |
| chr7_99671570_A_C | chr7:99671570 | 0.283 | 0.236 | 0.247 | — |
| chr7_99671501_T_G | chr7:99671501 | 0.281 | 0.360 | 0.326 | — |
| chr7_99671554_T_G | chr7:99671554 | -0.280 | -0.284 | -0.332 | — |
| chr7_99679996_C_G | chr7:99679996 | -0.280 | -0.114 | -0.312 | — |
| chr7_99679997_A_G | chr7:99679997 | 0.280 | 0.132 | 0.259 | — |
| chr7_99680004_A_T | chr7:99680004 | 0.280 | 0.119 | 0.200 | — |
| chr7_99671495_T_A | chr7:99671495 | 0.278 | 0.307 | 0.262 | — |
Showing 200 of 200 in this window. Scores are the p99-scaled [−1, 1] value; click a column to sort.