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CYP3A5
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of CYP3A5, reducing the inducible component of metabolic clearance specifically in CYP3A5-expressing individuals.
Affected substrate drugs (PharmGKB): tacrolimus; cyclosporine; everolimus; sirolimus; fentanyl; carbamazepine
Scored variants near CYP3A5
chr7:99,548,193..99,779,996, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr7_99680060_C_A | chr7:99680060 | -100,928 | -25,056 | -39,424 | — |
| chr7_99680041_G_T | chr7:99680041 | -97,024 | -22,848 | -43,776 | — |
| chr7_99680061_C_T | chr7:99680061 | -87,488 | -20,448 | -34,304 | — |
| chr7_99680063_A_T | chr7:99680063 | -82,240 | -19,744 | -35,456 | — |
| chr7_99680062_A_C | chr7:99680062 | -81,152 | -20,672 | -35,328 | — |
| chr7_99680061_C_A | chr7:99680061 | -75,392 | -17,696 | -29,184 | — |
| chr7_99680062_A_T | chr7:99680062 | -73,536 | -17,888 | -30,976 | — |
| chr7_99680048_C_G | chr7:99680048 | -73,472 | -16,768 | -34,688 | — |
| chr7_99680041_G_A | chr7:99680041 | -71,744 | -16,736 | -30,464 | — |
| chr7_99680060_C_G | chr7:99680060 | -71,424 | -17,568 | -23,680 | — |
| chr7_99680041_G_C | chr7:99680041 | -67,200 | -16,672 | -29,184 | — |
| chr7_99680060_C_T | chr7:99680060 | -64,256 | -16,256 | -24,448 | — |
| chr7_99680042_G_T | chr7:99680042 | -63,872 | -16,128 | -29,056 | — |
| chr7_99680061_C_G | chr7:99680061 | -61,376 | -14,688 | -21,504 | — |
| chr7_99680063_A_C | chr7:99680063 | -60,288 | -15,360 | -26,880 | — |
| chr7_99680063_A_G | chr7:99680063 | -59,968 | -15,360 | -26,624 | — |
| chr7_99680042_G_A | chr7:99680042 | -59,776 | -14,848 | -26,624 | — |
| chr7_99680045_G_A | chr7:99680045 | -58,432 | -12,672 | -24,064 | — |
| chr7_99680062_A_G | chr7:99680062 | -58,240 | -17,344 | -28,032 | — |
| chr7_99680040_A_T | chr7:99680040 | -56,448 | -12,864 | -22,272 | — |
| chr7_99680046_G_C | chr7:99680046 | -52,992 | -12,672 | -20,736 | — |
| chr7_99671516_G_C | chr7:99671516 | 51,968 | 16,864 | 23,808 | — |
| chr7_99680066_G_T | chr7:99680066 | -51,136 | -14,304 | -28,032 | — |
| chr7_99680081_C_G | chr7:99680081 | -51,008 | -10,144 | -22,784 | — |
| chr7_99680040_A_C | chr7:99680040 | -50,112 | -12,608 | -18,816 | — |
| chr7_99671533_T_A | chr7:99671533 | 48,128 | 14,944 | 25,216 | — |
| chr7_99680023_T_G | chr7:99680023 | -45,504 | -9,184 | -22,528 | — |
| chr7_99680011_C_A | chr7:99680011 | -44,864 | -10,816 | -22,400 | — |
| chr7_99680042_G_C | chr7:99680042 | -43,968 | -11,840 | -18,688 | — |
| chr7_99680064_T_A | chr7:99680064 | -42,944 | -10,912 | -16,768 | — |
| chr7_99680064_T_G | chr7:99680064 | -42,880 | -11,744 | -18,304 | — |
| chr7_99680058_A_C | chr7:99680058 | -41,920 | -11,360 | -16,384 | — |
| chr7_99680045_G_C | chr7:99680045 | -41,408 | -8,448 | -14,720 | — |
| chr7_99680023_T_A | chr7:99680023 | -41,344 | -7,584 | -20,480 | — |
| chr7_99671585_A_G | chr7:99671585 | 40,832 | 9,888 | 18,368 | — |
| chr7_99679979_T_A | chr7:99679979 | -39,168 | -7,392 | -16,768 | — |
| chr7_99680048_C_A | chr7:99680048 | -36,800 | -8,576 | -17,920 | — |
| chr7_99680064_T_C | chr7:99680064 | -36,224 | -9,824 | -15,360 | — |
| chr7_99680081_C_T | chr7:99680081 | -35,968 | -7,584 | -15,616 | — |
| chr7_99679973_T_A | chr7:99679973 | 34,688 | 2,336 | 20,352 | — |
| chr7_99680009_A_T | chr7:99680009 | -34,304 | -6,656 | -11,776 | — |
| chr7_99680059_G_T | chr7:99680059 | -32,960 | -7,072 | -13,184 | — |
| chr7_99680030_C_A | chr7:99680030 | -32,896 | -7,072 | -15,104 | — |
| chr7_99680047_G_C | chr7:99680047 | -32,640 | -6,016 | -12,928 | — |
| chr7_99679981_C_A | chr7:99679981 | 32,384 | 9,984 | 8,576 | — |
| chr7_99680010_G_T | chr7:99680010 | -32,000 | -3,232 | -12,032 | — |
| chr7_99680039_G_C | chr7:99680039 | -31,744 | -7,552 | -13,568 | — |
| chr7_99680059_G_C | chr7:99680059 | -31,488 | -6,784 | -11,776 | — |
| chr7_99680045_G_T | chr7:99680045 | -31,232 | -5,792 | -12,160 | — |
| chr7_99680006_C_A | chr7:99680006 | -30,336 | -5,824 | -12,032 | — |
| chr7_99680083_C_T | chr7:99680083 | -30,272 | -7,488 | -13,696 | — |
| chr7_99671585_A_T | chr7:99671585 | 30,208 | 7,072 | 13,376 | — |
| chr7_99679970_G_T | chr7:99679970 | -30,208 | -4,096 | -11,008 | — |
| chr7_99679971_C_T | chr7:99679971 | -30,208 | -3,456 | -13,568 | — |
| chr7_99680046_G_A | chr7:99680046 | -29,952 | -7,232 | -12,928 | — |
| chr7_99680046_G_T | chr7:99680046 | -29,632 | -7,008 | -12,928 | — |
| chr7_99679995_G_T | chr7:99679995 | -29,568 | -4,192 | -11,136 | — |
| chr7_99679997_A_T | chr7:99679997 | -28,928 | -6,432 | -8,320 | — |
| chr7_99679971_C_A | chr7:99679971 | -28,672 | -2,720 | -11,648 | — |
| chr7_99680006_C_T | chr7:99680006 | -27,776 | -4,608 | -11,008 | — |
| chr7_99680043_C_A | chr7:99680043 | -27,776 | -6,304 | -12,032 | — |
| chr7_99679970_G_C | chr7:99679970 | -27,648 | -3,808 | -10,368 | — |
| chr7_99680071_G_C | chr7:99680071 | 27,200 | 5,248 | 7,168 | — |
| chr7_99680007_C_A | chr7:99680007 | -26,880 | -4,128 | -10,496 | — |
| chr7_99680038_G_T | chr7:99680038 | -26,816 | -6,656 | -11,904 | — |
| chr7_99680043_C_G | chr7:99680043 | -26,816 | -6,016 | -10,752 | — |
| chr7_99671516_G_T | chr7:99671516 | 26,624 | 9,248 | 13,504 | — |
| chr7_99679972_C_A | chr7:99679972 | -26,112 | -2,176 | -10,880 | — |
| chr7_99679973_T_C | chr7:99679973 | 26,112 | 1,504 | 17,280 | — |
| chr7_99680043_C_T | chr7:99680043 | -25,920 | -5,408 | -10,624 | — |
| chr7_99680058_A_T | chr7:99680058 | -25,920 | -7,552 | -10,496 | — |
| chr7_99671593_A_T | chr7:99671593 | 25,792 | 8,768 | 13,952 | — |
| chr7_99671577_C_T | chr7:99671577 | 25,728 | 6,560 | 12,032 | — |
| chr7_99679964_C_G | chr7:99679964 | -25,088 | -2,528 | -11,520 | — |
| chr7_99680005_G_A | chr7:99680005 | -24,704 | -2,592 | -9,984 | — |
| chr7_99671485_A_G | chr7:99671485 | 24,576 | 7,520 | 11,072 | — |
| chr7_99671575_T_G | chr7:99671575 | 24,448 | 8,032 | 15,680 | — |
| chr7_99680026_T_G | chr7:99680026 | -24,000 | -5,056 | -12,416 | — |
| chr7_99680076_G_C | chr7:99680076 | -24,000 | -4,960 | -13,568 | — |
| chr7_99680066_G_C | chr7:99680066 | -23,872 | -6,720 | -12,160 | — |
| chr7_99680038_G_C | chr7:99680038 | -23,808 | -6,496 | -9,344 | — |
| chr7_99680007_C_T | chr7:99680007 | -23,168 | -4,352 | -8,320 | — |
| chr7_99671569_A_G | chr7:99671569 | 22,912 | 7,040 | 12,480 | — |
| chr7_99680005_G_C | chr7:99680005 | -22,912 | -2,112 | -10,880 | — |
| chr7_99680005_G_T | chr7:99680005 | -22,784 | -2,880 | -8,704 | — |
| chr7_99680081_C_A | chr7:99680081 | -22,784 | -5,280 | -10,880 | — |
| chr7_99679996_C_A | chr7:99679996 | -22,400 | -2,912 | -9,600 | — |
| chr7_99680080_A_C | chr7:99680080 | -22,208 | -4,352 | -11,904 | — |
| chr7_99680008_A_C | chr7:99680008 | -21,888 | -4,896 | -9,088 | — |
| chr7_99680003_C_A | chr7:99680003 | -21,120 | -4,032 | -8,960 | — |
| chr7_99679972_C_G | chr7:99679972 | -20,992 | -2,016 | -7,680 | — |
| chr7_99680079_C_T | chr7:99680079 | -20,736 | -4,384 | -9,600 | — |
| chr7_99680084_C_T | chr7:99680084 | -20,672 | -5,792 | -8,704 | — |
| chr7_99671575_T_A | chr7:99671575 | 20,544 | 5,824 | 11,584 | — |
| chr7_99679963_G_T | chr7:99679963 | -20,480 | -1,888 | -9,344 | — |
| chr7_99679981_C_G | chr7:99679981 | 20,096 | 4,224 | 7,424 | — |
| chr7_99680079_C_G | chr7:99680079 | -20,032 | -4,096 | -9,600 | — |
| chr7_99680007_C_G | chr7:99680007 | -19,840 | -2,560 | -4,224 | — |
| chr7_99679978_C_T | chr7:99679978 | 19,712 | 3,584 | 6,784 | — |
| chr7_99680054_C_A | chr7:99680054 | -19,648 | -3,968 | -8,960 | — |
| chr7_99679972_C_T | chr7:99679972 | -19,456 | -1,440 | -9,472 | — |
| chr7_99680006_C_G | chr7:99680006 | -19,456 | -3,872 | -7,296 | — |
| chr7_99680048_C_T | chr7:99680048 | -19,456 | -4,000 | -10,112 | — |
| chr7_99679963_G_C | chr7:99679963 | -19,328 | -2,464 | -7,808 | — |
| chr7_99680047_G_T | chr7:99680047 | -19,328 | -3,072 | -9,600 | — |
| chr7_99680027_G_T | chr7:99680027 | 18,816 | 5,216 | 4,864 | — |
| chr7_99671574_A_G | chr7:99671574 | 18,624 | 5,312 | 9,920 | — |
| chr7_99671553_T_G | chr7:99671553 | -18,240 | -6,176 | -11,200 | — |
| chr7_99679969_T_A | chr7:99679969 | -18,048 | -1,760 | -7,808 | — |
| chr7_99680085_C_A | chr7:99680085 | -17,728 | -4,000 | -7,936 | — |
| chr7_99679963_G_A | chr7:99679963 | -17,536 | -1,472 | -9,344 | — |
| chr7_99671553_T_A | chr7:99671553 | -17,472 | -5,920 | -10,816 | — |
| chr7_99679964_C_T | chr7:99679964 | -17,408 | -1,216 | -8,832 | — |
| chr7_99680059_G_A | chr7:99680059 | -17,408 | -3,168 | -6,656 | — |
| chr7_99679983_C_G | chr7:99679983 | 17,280 | 5,792 | 10,112 | — |
| chr7_99680080_A_T | chr7:99680080 | -17,216 | -3,200 | -9,728 | — |
| chr7_99680082_A_C | chr7:99680082 | -16,896 | -4,576 | -10,112 | — |
| chr7_99679974_G_T | chr7:99679974 | -16,768 | -1,824 | -8,192 | — |
| chr7_99671570_A_T | chr7:99671570 | 16,512 | 4,064 | 7,872 | — |
| chr7_99680009_A_C | chr7:99680009 | -16,512 | -2,720 | -2,560 | — |
| chr7_99679999_T_A | chr7:99679999 | 16,384 | 3,552 | 6,144 | — |
| chr7_99680021_A_G | chr7:99680021 | 16,384 | 4,256 | 896 | — |
| chr7_99671533_T_G | chr7:99671533 | 16,320 | 5,440 | 9,344 | — |
| chr7_99679985_G_T | chr7:99679985 | -16,128 | -3,040 | -4,224 | — |
| chr7_99680027_G_C | chr7:99680027 | 16,128 | 4,000 | 128 | — |
| chr7_99680023_T_C | chr7:99680023 | -15,936 | -2,784 | -9,984 | — |
| chr7_99680058_A_G | chr7:99680058 | -15,872 | -4,832 | -6,528 | — |
| chr7_99679989_T_G | chr7:99679989 | 15,744 | 1,152 | 8,064 | — |
| chr7_99671568_T_G | chr7:99671568 | 15,552 | 5,728 | 8,832 | — |
| chr7_99671569_A_C | chr7:99671569 | 15,552 | 5,184 | 8,576 | — |
| chr7_99680067_C_T | chr7:99680067 | -15,488 | -3,168 | -6,912 | — |
| chr7_99680085_C_T | chr7:99680085 | -15,424 | -2,976 | -6,400 | — |
| chr7_99679969_T_G | chr7:99679969 | -15,360 | -1,216 | -7,552 | — |
| chr7_99671485_A_T | chr7:99671485 | 15,296 | 4,736 | 6,912 | — |
| chr7_99671577_C_G | chr7:99671577 | -15,296 | -4,736 | -9,536 | — |
| chr7_99671593_A_C | chr7:99671593 | 15,232 | 4,480 | 8,384 | — |
| chr7_99679970_G_A | chr7:99679970 | -15,104 | 1,088 | -5,888 | — |
| chr7_99679974_G_C | chr7:99679974 | -15,104 | -1,888 | -3,328 | — |
| chr7_99679964_C_A | chr7:99679964 | -14,976 | -1,472 | -8,192 | — |
| chr7_99679982_C_G | chr7:99679982 | 14,976 | 3,840 | 5,760 | — |
| chr7_99680052_A_C | chr7:99680052 | 14,912 | 1,824 | 5,120 | — |
| chr7_99679969_T_C | chr7:99679969 | -14,848 | -1,600 | -4,096 | — |
| chr7_99671516_G_A | chr7:99671516 | 14,784 | 5,376 | 7,488 | — |
| chr7_99680085_C_G | chr7:99680085 | -14,528 | -3,872 | -3,584 | — |
| chr7_99680020_G_A | chr7:99680020 | -14,336 | -2,816 | -9,344 | — |
| chr7_99671577_C_A | chr7:99671577 | -14,208 | -4,320 | -9,152 | — |
| chr7_99680029_G_T | chr7:99680029 | -14,208 | -1,984 | -6,400 | — |
| chr7_99680037_A_T | chr7:99680037 | -14,080 | -2,592 | -6,656 | — |
| chr7_99680039_G_A | chr7:99680039 | -14,080 | -2,656 | -7,424 | — |
| chr7_99671520_A_C | chr7:99671520 | 13,952 | 4,896 | 8,960 | — |
| chr7_99679971_C_G | chr7:99679971 | -13,952 | -736 | -6,016 | — |
| chr7_99679986_C_A | chr7:99679986 | 13,824 | 3,936 | 2,304 | — |
| chr7_99680008_A_G | chr7:99680008 | -13,696 | -2,144 | -2,432 | — |
| chr7_99680057_C_A | chr7:99680057 | -13,632 | -3,328 | -6,912 | — |
| chr7_99680031_T_A | chr7:99680031 | -13,440 | -2,528 | -6,528 | — |
| chr7_99680079_C_A | chr7:99680079 | -13,440 | -2,816 | -7,296 | — |
| chr7_99679977_G_A | chr7:99679977 | 13,312 | 2,304 | 5,376 | — |
| chr7_99680052_A_T | chr7:99680052 | 13,248 | 2,368 | 4,864 | — |
| chr7_99680076_G_T | chr7:99680076 | -13,248 | -2,208 | -7,424 | — |
| chr7_99671564_C_T | chr7:99671564 | 12,992 | 5,408 | 7,104 | — |
| chr7_99679999_T_G | chr7:99679999 | 12,928 | 2,560 | 11,136 | — |
| chr7_99679988_C_G | chr7:99679988 | 12,800 | 2,880 | 13,696 | — |
| chr7_99671549_A_C | chr7:99671549 | -12,608 | -4,320 | -7,552 | — |
| chr7_99680044_A_C | chr7:99680044 | -12,608 | -2,400 | -5,760 | — |
| chr7_99679995_G_A | chr7:99679995 | -12,544 | -1,984 | -4,992 | — |
| chr7_99679974_G_A | chr7:99679974 | 12,416 | 2,976 | 640 | — |
| chr7_99680050_A_T | chr7:99680050 | 12,416 | 2,848 | 7,168 | — |
| chr7_99680051_T_G | chr7:99680051 | 12,416 | 1,824 | 4,992 | — |
| chr7_99671481_T_G | chr7:99671481 | 12,352 | 3,104 | 5,568 | — |
| chr7_99671547_T_A | chr7:99671547 | -12,352 | -4,224 | -8,640 | — |
| chr7_99680001_T_G | chr7:99680001 | 12,288 | 1,632 | 9,984 | — |
| chr7_99679984_T_C | chr7:99679984 | -12,160 | -3,872 | -768 | — |
| chr7_99671547_T_G | chr7:99671547 | -12,096 | -4,288 | -8,000 | — |
| chr7_99671555_G_C | chr7:99671555 | -11,968 | -4,064 | -8,064 | — |
| chr7_99680034_A_C | chr7:99680034 | 11,904 | 1,536 | 7,168 | — |
| chr7_99680019_A_G | chr7:99680019 | -11,776 | -2,400 | -7,296 | — |
| chr7_99680024_T_A | chr7:99680024 | 11,776 | 3,168 | 3,200 | — |
| chr7_99671553_T_C | chr7:99671553 | -11,712 | -4,000 | -7,744 | — |
| chr7_99671581_T_A | chr7:99671581 | -11,712 | -3,712 | -6,848 | — |
| chr7_99671555_G_A | chr7:99671555 | -11,648 | -3,968 | -8,128 | — |
| chr7_99680068_A_T | chr7:99680068 | -11,584 | -4,064 | -5,888 | — |
| chr7_99680019_A_T | chr7:99680019 | 11,520 | 3,584 | 5,632 | — |
| chr7_99671549_A_T | chr7:99671549 | -11,456 | -4,096 | -7,424 | — |
| chr7_99671570_A_G | chr7:99671570 | 11,456 | 3,392 | 5,824 | — |
| chr7_99671555_G_T | chr7:99671555 | -11,392 | -3,904 | -8,064 | — |
| chr7_99680010_G_C | chr7:99680010 | -11,392 | 512 | -5,376 | — |
| chr7_99680012_T_A | chr7:99680012 | -11,264 | -2,208 | -5,248 | — |
| chr7_99680016_G_T | chr7:99680016 | -11,264 | -1,984 | -7,680 | — |
| chr7_99671579_A_T | chr7:99671579 | -11,200 | -3,808 | -7,104 | — |
| chr7_99680080_A_G | chr7:99680080 | -11,136 | -2,144 | -4,352 | — |
| chr7_99671579_A_G | chr7:99671579 | -11,008 | -3,680 | -7,040 | — |
| chr7_99680011_C_G | chr7:99680011 | 11,008 | -2,464 | -4,864 | — |
| chr7_99680055_T_A | chr7:99680055 | 11,008 | 2,368 | 4,224 | — |
| chr7_99671570_A_C | chr7:99671570 | 10,880 | 2,976 | 5,376 | — |
| chr7_99671501_T_G | chr7:99671501 | 10,816 | 4,544 | 7,104 | — |
| chr7_99671554_T_G | chr7:99671554 | -10,752 | -3,584 | -7,232 | — |
| chr7_99679996_C_G | chr7:99679996 | -10,752 | -1,440 | -6,784 | — |
| chr7_99679997_A_G | chr7:99679997 | 10,752 | 1,664 | 5,632 | — |
| chr7_99680004_A_T | chr7:99680004 | 10,752 | 1,504 | 4,352 | — |
| chr7_99671495_T_A | chr7:99671495 | 10,688 | 3,872 | 5,696 | — |
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