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FGF19
receptor: FXRTier 1
CAMIP causal chains
FXR
Attenuated receptor-mediated transcriptional activation of enterocyte FGF19, disrupting the intestinal endocrine signaling cascade required for the downstream feedback repression of hepatic bile acid biosynthesis.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near FGF19
chr11:69,598,237..69,804,022, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr11_69688546_T_A | chr11:69688546 | 19,776 | 5,920 | 8,448 | — |
| chr11_69688546_T_G | chr11:69688546 | 18,496 | 5,536 | 8,064 | — |
| chr11_69639073_A_C | chr11:69639073 | 14,432 | 3,968 | 12,288 | — |
| chr11_69688561_T_G | chr11:69688561 | 13,056 | 4,224 | 5,760 | — |
| chr11_69688555_G_T | chr11:69688555 | -11,712 | -4,256 | -8,960 | — |
| chr11_69688548_T_G | chr11:69688548 | 10,816 | 4,672 | 4,992 | — |
| chr11_69639076_A_C | chr11:69639076 | 10,688 | 2,752 | 9,984 | — |
| chr11_69639062_C_G | chr11:69639062 | -10,400 | -2,016 | -6,656 | 6.6e-6 |
| chr11_69638982_T_G | chr11:69638982 | 9,728 | 3,488 | 9,216 | — |
| chr11_69639077_A_C | chr11:69639077 | 9,504 | 1,536 | 9,472 | — |
| chr11_69688566_C_G | chr11:69688566 | -9,472 | -3,488 | -4,480 | 6.6e-6 |
| chr11_69688559_T_G | chr11:69688559 | 9,280 | 3,040 | 4,224 | — |
| chr11_69688568_T_A | chr11:69688568 | 8,960 | 3,136 | 4,352 | — |
| chr11_69688554_A_T | chr11:69688554 | 8,512 | 3,040 | 3,968 | — |
| chr11_69688564_A_C | chr11:69688564 | -8,448 | -3,232 | -3,456 | — |
| chr11_69688563_A_C | chr11:69688563 | -8,192 | -3,040 | -3,840 | — |
| chr11_69688565_A_T | chr11:69688565 | -8,192 | -2,432 | -2,432 | — |
| chr11_69639029_A_T | chr11:69639029 | 8,128 | 2,336 | -2,304 | — |
| chr11_69638962_T_G | chr11:69638962 | 8,096 | 2,176 | 9,728 | — |
| chr11_69688564_A_T | chr11:69688564 | -8,064 | -3,232 | -3,840 | — |
| chr11_69639045_T_G | chr11:69639045 | 7,904 | 1,600 | 9,216 | — |
| chr11_69688563_A_T | chr11:69688563 | -7,680 | -2,688 | -4,864 | — |
| chr11_69688551_C_A | chr11:69688551 | 7,616 | 2,880 | 4,224 | — |
| chr11_69639027_C_T | chr11:69639027 | -7,584 | -1,472 | -5,888 | — |
| chr11_69639090_G_T | chr11:69639090 | 7,552 | 2,304 | 7,424 | — |
| chr11_69639045_T_C | chr11:69639045 | 7,488 | 1,440 | 9,216 | — |
| chr11_69688562_C_T | chr11:69688562 | -7,488 | -2,688 | -4,480 | — |
| chr11_69688562_C_A | chr11:69688562 | -7,296 | -2,720 | -4,096 | — |
| chr11_69688563_A_G | chr11:69688563 | -7,296 | -2,688 | -1,920 | — |
| chr11_69688571_C_T | chr11:69688571 | -7,232 | -2,464 | -4,480 | — |
| chr11_69641834_C_G | chr11:69641834 | 7,104 | 1,616 | 1,536 | — |
| chr11_69639042_A_C | chr11:69639042 | 6,976 | 2,400 | 9,472 | 1.0e-3 |
| chr11_69688568_T_C | chr11:69688568 | 6,976 | 1,632 | 4,480 | — |
| chr11_69639088_G_C | chr11:69639088 | 6,912 | 2,432 | 8,448 | — |
| chr11_69688573_A_G | chr11:69688573 | 6,720 | 2,176 | 4,224 | — |
| chr11_69688565_A_C | chr11:69688565 | -6,656 | -2,336 | -640 | — |
| chr11_69638980_A_T | chr11:69638980 | 6,528 | 1,216 | 7,168 | — |
| chr11_69688544_C_A | chr11:69688544 | -6,496 | -2,272 | -6,528 | — |
| chr11_69639082_C_A | chr11:69639082 | 6,304 | 2,400 | 5,120 | — |
| chr11_69639074_C_T | chr11:69639074 | 6,272 | 2,368 | 7,936 | 6.6e-6 |
| chr11_69688564_A_G | chr11:69688564 | -6,272 | -2,464 | -2,560 | — |
| chr11_69688569_A_C | chr11:69688569 | -6,272 | -2,048 | -3,072 | — |
| chr11_69639047_G_C | chr11:69639047 | 6,176 | 1,056 | 7,936 | — |
| chr11_69639076_A_T | chr11:69639076 | 6,144 | 2,304 | 9,984 | — |
| chr11_69638995_C_G | chr11:69638995 | 6,144 | 256 | 6,656 | — |
| chr11_69688565_A_G | chr11:69688565 | -6,080 | -2,016 | -1,536 | — |
| chr11_69641732_A_G | chr11:69641732 | -5,952 | -2,352 | -17,536 | — |
| chr11_69639078_G_C | chr11:69639078 | 5,920 | 2,560 | 11,520 | — |
| chr11_69638995_C_A | chr11:69638995 | 5,920 | 64 | 6,400 | — |
| chr11_69688558_A_G | chr11:69688558 | -5,888 | -2,208 | -1,024 | — |
| chr11_69639029_A_C | chr11:69639029 | 5,824 | 1,472 | 768 | — |
| chr11_69688560_T_A | chr11:69688560 | -5,760 | -2,976 | -3,456 | — |
| chr11_69639077_A_G | chr11:69639077 | 5,600 | 816 | 6,144 | — |
| chr11_69639033_G_T | chr11:69639033 | 5,536 | 2,400 | 6,656 | — |
| chr11_69641747_A_G | chr11:69641747 | -5,440 | -976 | -14,464 | — |
| chr11_69639074_C_A | chr11:69639074 | -5,440 | -912 | -3,840 | 6.6e-6 |
| chr11_69639010_A_C | chr11:69639010 | 5,408 | 1,184 | 4,096 | — |
| chr11_69688547_T_C | chr11:69688547 | -5,376 | -1,600 | -3,712 | 6.6e-6 |
| chr11_69639078_G_T | chr11:69639078 | 5,344 | 896 | 6,656 | — |
| chr11_69688559_T_C | chr11:69688559 | -5,312 | -1,632 | -1,536 | — |
| chr11_69638964_C_G | chr11:69638964 | 5,184 | 1,568 | 9,472 | — |
| chr11_69688570_C_G | chr11:69688570 | 5,184 | 1,824 | 4,352 | — |
| chr11_69638994_C_A | chr11:69638994 | 5,088 | 576 | 5,632 | — |
| chr11_69639079_T_C | chr11:69639079 | 4,960 | -96 | 5,120 | — |
| chr11_69638984_C_G | chr11:69638984 | 4,960 | 992 | 4,608 | — |
| chr11_69639062_C_A | chr11:69639062 | -4,960 | -448 | -3,072 | — |
| chr11_69638994_C_T | chr11:69638994 | 4,928 | 128 | 5,376 | — |
| chr11_69639044_T_A | chr11:69639044 | 4,928 | 1,184 | 5,376 | — |
| chr11_69638981_A_G | chr11:69638981 | 4,928 | 960 | 5,120 | — |
| chr11_69638963_T_C | chr11:69638963 | 4,928 | 1,120 | 3,840 | — |
| chr11_69688574_A_G | chr11:69688574 | 4,864 | 1,664 | 2,560 | — |
| chr11_69688577_G_A | chr11:69688577 | -4,864 | -1,888 | -4,608 | — |
| chr11_69639048_C_G | chr11:69639048 | -4,768 | -832 | -5,888 | — |
| chr11_69638976_C_T | chr11:69638976 | 4,736 | 992 | 3,328 | — |
| chr11_69638991_C_A | chr11:69638991 | -4,736 | -1,376 | -2,048 | — |
| chr11_69639046_T_G | chr11:69639046 | 4,672 | 1,760 | 6,912 | — |
| chr11_69639008_G_C | chr11:69639008 | -4,640 | -2,048 | -7,424 | — |
| chr11_69638977_C_A | chr11:69638977 | 4,544 | 736 | 6,656 | — |
| chr11_69688550_A_T | chr11:69688550 | -4,544 | -1,536 | -3,200 | — |
| chr11_69639050_C_G | chr11:69639050 | -4,480 | -1,344 | -3,584 | — |
| chr11_69688567_A_C | chr11:69688567 | -4,480 | -1,408 | -896 | — |
| chr11_69638976_C_A | chr11:69638976 | 4,448 | 1,056 | 5,888 | — |
| chr11_69639011_C_G | chr11:69639011 | -4,448 | -608 | -4,096 | — |
| chr11_69641741_T_G | chr11:69641741 | -4,416 | -1,184 | -12,416 | — |
| chr11_69638999_C_G | chr11:69638999 | -4,384 | -928 | -5,120 | — |
| chr11_69638961_A_T | chr11:69638961 | 4,352 | 1,152 | 5,120 | — |
| chr11_69638963_T_G | chr11:69638963 | 4,320 | 1,248 | 8,448 | — |
| chr11_69639044_T_G | chr11:69639044 | 4,320 | 896 | 6,144 | — |
| chr11_69639093_C_G | chr11:69639093 | -4,288 | -1,152 | -5,632 | 2.0e-5 |
| chr11_69639023_C_G | chr11:69639023 | 4,288 | 1,824 | 4,608 | — |
| chr11_69639075_G_A | chr11:69639075 | 4,192 | 1,792 | 6,912 | — |
| chr11_69639040_C_A | chr11:69639040 | -4,192 | -1,280 | -5,632 | — |
| chr11_69638981_A_T | chr11:69638981 | 4,160 | 1,216 | 6,144 | — |
| chr11_69638960_A_T | chr11:69638960 | 4,128 | 768 | 4,864 | — |
| chr11_69639042_A_G | chr11:69639042 | 4,128 | 768 | 4,864 | — |
| chr11_69638995_C_T | chr11:69638995 | 4,128 | 96 | 4,608 | — |
| chr11_69688556_A_T | chr11:69688556 | -4,032 | -704 | -4,992 | — |
| chr11_69638965_C_G | chr11:69638965 | 4,000 | 1,888 | 7,168 | — |
| chr11_69641752_T_G | chr11:69641752 | -3,968 | -896 | -10,496 | — |
| chr11_69639012_G_A | chr11:69639012 | 3,936 | 672 | 5,888 | — |
| chr11_69638981_A_C | chr11:69638981 | 3,904 | 544 | 4,352 | — |
| chr11_69641738_G_T | chr11:69641738 | 3,712 | 1,120 | 10,496 | — |
| chr11_69638962_T_A | chr11:69638962 | 3,712 | 1,344 | 5,888 | — |
| chr11_69639080_T_G | chr11:69639080 | 3,680 | 672 | 5,120 | — |
| chr11_69639045_T_A | chr11:69639045 | 3,648 | 832 | 7,680 | — |
| chr11_69638956_C_T | chr11:69638956 | 3,616 | 1,120 | 6,144 | — |
| chr11_69638977_C_G | chr11:69638977 | 3,616 | 128 | 6,144 | — |
| chr11_69639089_A_T | chr11:69639089 | 3,552 | 1,552 | 8,704 | — |
| chr11_69639090_G_A | chr11:69639090 | -3,520 | -416 | -4,608 | — |
| chr11_69639046_T_C | chr11:69639046 | 3,488 | 928 | 5,632 | — |
| chr11_69639035_G_A | chr11:69639035 | 3,488 | 1,440 | 4,608 | — |
| chr11_69639079_T_G | chr11:69639079 | 3,488 | 512 | 4,352 | — |
| chr11_69688561_T_C | chr11:69688561 | -3,392 | -3,584 | -9,344 | — |
| chr11_69638996_C_G | chr11:69638996 | 3,392 | 128 | 6,144 | — |
| chr11_69641739_G_A | chr11:69641739 | 3,328 | 1,424 | 9,728 | 6.6e-6 |
| chr11_69639053_G_A | chr11:69639053 | -3,328 | -1,440 | -5,120 | — |
| chr11_69638998_G_C | chr11:69638998 | -3,296 | -352 | -5,888 | — |
| chr11_69639084_A_C | chr11:69639084 | -3,296 | -1,376 | -5,376 | — |
| chr11_69641739_G_T | chr11:69641739 | 3,264 | 1,120 | 8,576 | — |
| chr11_69638959_A_T | chr11:69638959 | 3,264 | 1,184 | 6,912 | — |
| chr11_69639022_G_T | chr11:69639022 | -3,264 | -800 | -6,400 | — |
| chr11_69638964_C_A | chr11:69638964 | 3,232 | 1,472 | 7,168 | — |
| chr11_69641743_C_G | chr11:69641743 | -3,104 | -1,248 | -10,368 | — |
| chr11_69638979_A_T | chr11:69638979 | 3,104 | 960 | 5,376 | — |
| chr11_69641739_G_C | chr11:69641739 | 3,008 | 1,360 | 10,880 | — |
| chr11_69641738_G_A | chr11:69641738 | 3,008 | 1,424 | 9,856 | — |
| chr11_69641830_T_G | chr11:69641830 | -3,008 | -336 | -5,760 | — |
| chr11_69639041_A_C | chr11:69639041 | 2,976 | 1,344 | 8,704 | — |
| chr11_69641735_A_G | chr11:69641735 | -2,944 | -1,072 | -8,960 | — |
| chr11_69638983_T_G | chr11:69638983 | 2,944 | 704 | 5,120 | — |
| chr11_69638956_C_A | chr11:69638956 | 2,848 | 960 | 6,400 | — |
| chr11_69641738_G_C | chr11:69641738 | 2,816 | 1,440 | 11,520 | — |
| chr11_69641750_G_T | chr11:69641750 | 2,816 | 912 | 8,064 | — |
| chr11_69638993_C_T | chr11:69638993 | 2,752 | 224 | 5,632 | — |
| chr11_69638975_C_T | chr11:69638975 | 2,720 | 1,152 | 4,352 | — |
| chr11_69639029_A_G | chr11:69639029 | 2,688 | 992 | 4,352 | — |
| chr11_69638968_C_A | chr11:69638968 | -2,656 | -480 | -5,376 | — |
| chr11_69639091_A_C | chr11:69639091 | 2,656 | 880 | 4,864 | — |
| chr11_69641737_G_A | chr11:69641737 | 2,624 | 1,072 | 8,448 | — |
| chr11_69641748_G_C | chr11:69641748 | 2,624 | 592 | 6,016 | — |
| chr11_69639075_G_C | chr11:69639075 | 2,624 | 928 | 5,888 | 6.6e-6 |
| chr11_69638962_T_C | chr11:69638962 | 2,592 | 448 | 5,120 | — |
| chr11_69641734_A_G | chr11:69641734 | -2,560 | -1,088 | -7,808 | — |
| chr11_69638965_C_A | chr11:69638965 | 2,560 | 1,696 | 6,912 | — |
| chr11_69641750_G_A | chr11:69641750 | 2,496 | 992 | 8,320 | — |
| chr11_69641748_G_T | chr11:69641748 | 2,496 | 656 | 6,528 | — |
| chr11_69638992_T_C | chr11:69638992 | -2,464 | -576 | -6,656 | — |
| chr11_69641744_G_C | chr11:69641744 | 2,432 | 944 | 8,320 | — |
| chr11_69641762_A_G | chr11:69641762 | -2,432 | -448 | -4,608 | — |
| chr11_69638979_A_C | chr11:69638979 | 2,400 | 992 | 4,864 | — |
| chr11_69641740_G_A | chr11:69641740 | 2,368 | 1,072 | 7,296 | — |
| chr11_69641737_G_C | chr11:69641737 | 2,304 | 1,184 | 9,472 | — |
| chr11_69641737_G_T | chr11:69641737 | 2,304 | 1,264 | 7,680 | — |
| chr11_69641802_C_G | chr11:69641802 | -2,304 | -64 | -4,992 | — |
| chr11_69688574_A_C | chr11:69688574 | 2,304 | 1,120 | 4,736 | 6.6e-6 |
| chr11_69638955_C_A | chr11:69638955 | 2,272 | 1,216 | 4,352 | — |
| chr11_69641750_G_C | chr11:69641750 | 2,240 | 1,056 | 8,448 | — |
| chr11_69638956_C_G | chr11:69638956 | 2,144 | 800 | 4,864 | — |
| chr11_69639089_A_C | chr11:69639089 | 2,112 | 512 | 6,656 | — |
| chr11_69641740_G_C | chr11:69641740 | 2,048 | 1,008 | 7,168 | — |
| chr11_69641749_G_T | chr11:69641749 | 1,984 | 576 | 5,632 | — |
| chr11_69639043_T_A | chr11:69639043 | 1,920 | 896 | 4,352 | — |
| chr11_69641749_G_C | chr11:69641749 | 1,856 | 544 | 6,656 | — |
| chr11_69641745_G_T | chr11:69641745 | 1,856 | 704 | 5,120 | — |
| chr11_69639041_A_T | chr11:69639041 | 1,792 | 192 | 5,632 | — |
| chr11_69639066_G_C | chr11:69639066 | 1,664 | 1,696 | 7,680 | 2.0e-5 |
| chr11_69641740_G_T | chr11:69641740 | 1,600 | 992 | 5,760 | — |
| chr11_69639083_T_A | chr11:69639083 | -1,600 | -1,056 | -5,120 | — |
| chr11_69641746_G_C | chr11:69641746 | 1,600 | 464 | 4,480 | — |
| chr11_69639002_G_A | chr11:69639002 | -1,568 | -1,184 | -5,376 | — |
| chr11_69641855_T_C | chr11:69641855 | -1,536 | -464 | -5,120 | — |
| chr11_69638944_T_C | chr11:69638944 | -1,440 | -480 | -4,608 | — |
| chr11_69641736_G_C | chr11:69641736 | 1,408 | 944 | 7,808 | — |
| chr11_69641746_G_A | chr11:69641746 | 1,408 | 880 | 6,272 | — |
| chr11_69641748_G_A | chr11:69641748 | 1,408 | 528 | 6,144 | — |
| chr11_69638959_A_C | chr11:69638959 | 1,408 | 896 | 5,376 | — |
| chr11_69641749_G_A | chr11:69641749 | 1,344 | 416 | 5,632 | 2.0e-5 |
| chr11_69641736_G_T | chr11:69641736 | 1,344 | 608 | 4,736 | — |
| chr11_69638957_C_A | chr11:69638957 | 1,344 | 320 | 4,608 | — |
| chr11_69639066_G_T | chr11:69639066 | -1,312 | 640 | 4,352 | — |
| chr11_69639099_G_C | chr11:69639099 | -1,248 | -720 | -4,608 | — |
| chr11_69639092_T_C | chr11:69639092 | -1,216 | -448 | -7,424 | — |
| chr11_69639007_T_G | chr11:69639007 | 1,184 | 1,248 | 4,608 | — |
| chr11_69641736_G_A | chr11:69641736 | 1,152 | 624 | 5,248 | — |
| chr11_69641745_G_C | chr11:69641745 | 1,152 | 544 | 5,248 | — |
| chr11_69639066_G_A | chr11:69639066 | 1,088 | 1,152 | 6,144 | — |
| chr11_69639071_C_G | chr11:69639071 | 1,056 | 256 | 4,864 | — |
| chr11_69639026_G_A | chr11:69639026 | -896 | -96 | -4,352 | — |
| chr11_69638966_A_C | chr11:69638966 | -832 | 832 | 4,608 | — |
| chr11_69641847_A_G | chr11:69641847 | -832 | -352 | -4,480 | — |
| chr11_69639040_C_G | chr11:69639040 | 576 | -1,152 | -5,632 | — |
| chr11_69638964_C_T | chr11:69638964 | 480 | 1,248 | 5,120 | — |
| chr11_69639006_C_G | chr11:69639006 | -448 | 992 | 5,632 | — |
| chr11_69638986_A_C | chr11:69638986 | 448 | 704 | 5,376 | — |
| chr11_69639039_G_T | chr11:69639039 | -416 | 960 | 5,376 | — |
| chr11_69639079_T_A | chr11:69639079 | -384 | -1,104 | -4,608 | — |
| chr11_69639084_A_G | chr11:69639084 | 320 | 1,360 | 5,632 | — |
| chr11_69639093_C_T | chr11:69639093 | -192 | 112 | -5,632 | — |
| chr11_69639069_A_G | chr11:69639069 | -160 | 304 | 6,656 | — |
| chr11_69639064_G_C | chr11:69639064 | 64 | 2,240 | 10,240 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.