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SLC10A1
receptor: FXRTier 1
CAMIP causal chains
FXR
Reduced FXR binding would weaken FXR-driven SHP induction; with SHP-mediated repression relieved, SLC10A1/NTCP expression would rise, thus increasing the hepatic clearance of NTCP substrates.
Affected substrate drugs (PharmGKB): rosuvastatin
Scored variants near SLC10A1
chr14:69,675,415..69,897,241, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr14_69685917_G_A | chr14:69685917 | 118,912 | 27,616 | 53,504 | — |
| chr14_69685885_T_G | chr14:69685885 | 90,240 | 24,416 | 34,816 | — |
| chr14_69685888_G_C | chr14:69685888 | 86,016 | 18,496 | 34,944 | — |
| chr14_69685888_G_A | chr14:69685888 | 76,736 | 20,256 | 30,080 | — |
| chr14_69685844_A_C | chr14:69685844 | 72,768 | 17,248 | 33,920 | — |
| chr14_69685844_A_T | chr14:69685844 | 71,232 | 16,064 | 34,048 | — |
| chr14_69685913_A_C | chr14:69685913 | 68,992 | 19,392 | 38,528 | — |
| chr14_69685862_T_A | chr14:69685862 | 65,024 | 18,080 | 29,952 | — |
| chr14_69685899_G_T | chr14:69685899 | 59,840 | 4,960 | 10,368 | — |
| chr14_69685905_A_C | chr14:69685905 | -57,344 | -11,968 | -34,368 | — |
| chr14_69685939_C_T | chr14:69685939 | -55,488 | -11,424 | -29,248 | — |
| chr14_69685937_G_C | chr14:69685937 | -55,040 | -10,592 | -29,376 | — |
| chr14_69685866_T_C | chr14:69685866 | 54,784 | 16,256 | 28,032 | — |
| chr14_69685939_C_A | chr14:69685939 | -54,528 | -10,912 | -28,800 | — |
| chr14_69685862_T_G | chr14:69685862 | 54,336 | 15,328 | 24,704 | — |
| chr14_69685937_G_A | chr14:69685937 | -54,080 | -10,304 | -29,248 | — |
| chr14_69685939_C_G | chr14:69685939 | -53,568 | -11,264 | -24,256 | — |
| chr14_69685872_G_C | chr14:69685872 | 52,928 | 12,960 | 21,248 | — |
| chr14_69685938_C_T | chr14:69685938 | -51,520 | -8,320 | -26,432 | — |
| chr14_69685871_T_G | chr14:69685871 | 49,152 | 13,568 | 16,640 | — |
| chr14_69685938_C_A | chr14:69685938 | -49,088 | -8,256 | -24,896 | — |
| chr14_69685930_G_T | chr14:69685930 | -45,248 | -7,200 | -24,576 | — |
| chr14_69685899_G_C | chr14:69685899 | 45,120 | 10,208 | 21,632 | — |
| chr14_69685885_T_A | chr14:69685885 | 44,736 | 11,072 | 20,224 | — |
| chr14_69685929_G_T | chr14:69685929 | -44,288 | -7,584 | -24,640 | — |
| chr14_69685941_G_C | chr14:69685941 | -43,712 | -7,200 | -19,712 | — |
| chr14_69685929_G_A | chr14:69685929 | -42,560 | -7,520 | -24,448 | — |
| chr14_69685931_C_T | chr14:69685931 | -42,048 | -6,976 | -20,224 | — |
| chr14_69685930_G_A | chr14:69685930 | -41,984 | -6,272 | -22,720 | — |
| chr14_69685929_G_C | chr14:69685929 | -41,664 | -8,064 | -23,232 | — |
| chr14_69685930_G_C | chr14:69685930 | -40,960 | -6,272 | -20,992 | — |
| chr14_69685895_C_T | chr14:69685895 | 40,640 | 10,336 | 18,432 | — |
| chr14_69685888_G_T | chr14:69685888 | 40,320 | 9,984 | 19,328 | — |
| chr14_69685931_C_G | chr14:69685931 | -40,320 | -5,824 | -18,816 | — |
| chr14_69685915_C_G | chr14:69685915 | -40,000 | -9,568 | -22,656 | — |
| chr14_69685914_G_C | chr14:69685914 | 39,680 | 9,472 | 12,416 | — |
| chr14_69685907_C_G | chr14:69685907 | -39,616 | -8,704 | -16,128 | — |
| chr14_69685920_G_T | chr14:69685920 | -39,488 | -8,064 | -22,080 | — |
| chr14_69685928_T_C | chr14:69685928 | -39,296 | -7,296 | -21,376 | — |
| chr14_69685862_T_C | chr14:69685862 | 39,104 | 10,624 | 16,128 | — |
| chr14_69685940_A_T | chr14:69685940 | -38,656 | -7,296 | -20,608 | — |
| chr14_69685941_G_T | chr14:69685941 | -38,656 | -6,656 | -17,216 | — |
| chr14_69685937_G_T | chr14:69685937 | -38,528 | -7,584 | -19,840 | — |
| chr14_69685938_C_G | chr14:69685938 | -38,464 | -6,432 | -18,112 | — |
| chr14_69685962_G_T | chr14:69685962 | -37,888 | -5,760 | -19,136 | — |
| chr14_69685950_A_C | chr14:69685950 | -37,440 | -5,024 | -17,216 | — |
| chr14_69685907_C_T | chr14:69685907 | -37,248 | -8,768 | -16,896 | — |
| chr14_69685940_A_G | chr14:69685940 | -36,864 | -8,576 | -21,248 | — |
| chr14_69685928_T_A | chr14:69685928 | -35,968 | -6,592 | -19,904 | — |
| chr14_69685880_A_T | chr14:69685880 | -35,712 | -9,408 | -20,288 | — |
| chr14_69685849_C_G | chr14:69685849 | -35,392 | -9,664 | -22,592 | — |
| chr14_69685877_T_A | chr14:69685877 | -34,048 | -8,480 | -16,000 | — |
| chr14_69685928_T_G | chr14:69685928 | -33,856 | -6,816 | -20,224 | — |
| chr14_69685874_A_C | chr14:69685874 | 33,728 | 10,624 | 19,584 | — |
| chr14_69685886_G_T | chr14:69685886 | -33,472 | -8,416 | -19,584 | — |
| chr14_69685878_G_A | chr14:69685878 | -33,344 | -7,616 | -18,880 | — |
| chr14_69685882_T_A | chr14:69685882 | -33,344 | -7,552 | -16,128 | — |
| chr14_69685884_T_A | chr14:69685884 | -32,896 | -8,288 | -17,408 | — |
| chr14_69685878_G_C | chr14:69685878 | -32,640 | -7,296 | -18,112 | — |
| chr14_69685877_T_G | chr14:69685877 | -32,512 | -8,384 | -15,936 | — |
| chr14_69685879_G_C | chr14:69685879 | -32,128 | -9,440 | -15,104 | — |
| chr14_69685927_G_T | chr14:69685927 | 32,000 | 5,472 | 14,848 | — |
| chr14_69685886_G_A | chr14:69685886 | -31,168 | -7,520 | -14,464 | — |
| chr14_69685881_C_G | chr14:69685881 | -30,656 | -8,704 | -17,728 | — |
| chr14_69685882_T_C | chr14:69685882 | 30,656 | 8,512 | 14,592 | — |
| chr14_69685880_A_G | chr14:69685880 | -30,464 | -8,512 | -17,728 | — |
| chr14_69685910_T_G | chr14:69685910 | 30,336 | 9,312 | 22,656 | — |
| chr14_69685861_C_G | chr14:69685861 | 30,272 | 8,864 | 14,464 | 6.6e-6 |
| chr14_69685879_G_T | chr14:69685879 | -29,888 | -7,552 | -18,624 | — |
| chr14_69685860_C_T | chr14:69685860 | -29,760 | -7,840 | -16,000 | — |
| chr14_69685907_C_A | chr14:69685907 | -29,376 | -5,312 | -11,904 | — |
| chr14_69685927_G_C | chr14:69685927 | 29,056 | 3,680 | 15,104 | — |
| chr14_69685915_C_A | chr14:69685915 | -28,992 | -6,688 | -16,384 | — |
| chr14_69685940_A_C | chr14:69685940 | -28,992 | -5,408 | -13,888 | — |
| chr14_69685878_G_T | chr14:69685878 | -28,608 | -6,656 | -16,768 | — |
| chr14_69685886_G_C | chr14:69685886 | -28,480 | -7,616 | -15,680 | — |
| chr14_69685845_T_C | chr14:69685845 | 28,288 | 7,936 | 15,104 | — |
| chr14_69685852_C_A | chr14:69685852 | 28,160 | 6,592 | 11,392 | — |
| chr14_69685881_C_T | chr14:69685881 | -28,160 | -7,872 | -18,560 | — |
| chr14_69685971_G_T | chr14:69685971 | -27,712 | -3,648 | -14,592 | — |
| chr14_69685913_A_T | chr14:69685913 | 27,520 | 6,432 | 13,696 | — |
| chr14_69685877_T_C | chr14:69685877 | -27,008 | -7,200 | -12,288 | — |
| chr14_69685908_T_C | chr14:69685908 | -26,688 | -6,176 | -16,192 | — |
| chr14_69685889_C_G | chr14:69685889 | -26,304 | -6,784 | -13,760 | — |
| chr14_69685884_T_G | chr14:69685884 | -25,792 | -6,720 | -12,928 | — |
| chr14_69685828_C_G | chr14:69685828 | -25,408 | -7,680 | -15,616 | — |
| chr14_69685851_C_T | chr14:69685851 | -25,216 | -6,560 | -13,440 | 2.0e-5 |
| chr14_69685876_T_A | chr14:69685876 | -25,216 | -5,952 | -12,992 | — |
| chr14_69685853_C_G | chr14:69685853 | 25,088 | 6,400 | 15,616 | — |
| chr14_69685825_G_A | chr14:69685825 | -25,024 | -7,040 | -15,104 | — |
| chr14_69685898_A_G | chr14:69685898 | 24,768 | 5,952 | 11,776 | — |
| chr14_69685828_C_A | chr14:69685828 | -24,320 | -7,008 | -17,152 | — |
| chr14_69685835_A_C | chr14:69685835 | 24,320 | 5,856 | 9,728 | — |
| chr14_69685847_G_C | chr14:69685847 | -24,192 | -6,304 | -16,640 | — |
| chr14_69685883_T_G | chr14:69685883 | -24,000 | -6,880 | -11,264 | — |
| chr14_69685891_G_T | chr14:69685891 | -23,808 | -5,056 | -11,648 | — |
| chr14_69685887_T_A | chr14:69685887 | 23,744 | 6,048 | 11,904 | — |
| chr14_69685858_T_G | chr14:69685858 | 23,616 | 5,792 | 9,088 | — |
| chr14_69685894_G_T | chr14:69685894 | -23,424 | -5,536 | -14,016 | — |
| chr14_69685843_A_G | chr14:69685843 | -23,296 | -4,736 | -16,896 | 6.6e-6 |
| chr14_69685933_G_T | chr14:69685933 | -23,296 | -2,336 | -4,800 | — |
| chr14_69685829_T_G | chr14:69685829 | -23,232 | -6,304 | -11,264 | — |
| chr14_69685898_A_T | chr14:69685898 | 23,168 | 6,016 | 11,776 | — |
| chr14_69685889_C_A | chr14:69685889 | -22,784 | -6,176 | -11,712 | — |
| chr14_69685832_G_C | chr14:69685832 | -22,720 | -2,784 | -5,504 | — |
| chr14_69685882_T_G | chr14:69685882 | -22,656 | -6,016 | -8,832 | — |
| chr14_69685915_C_T | chr14:69685915 | -22,592 | -5,376 | -12,160 | — |
| chr14_69685859_G_T | chr14:69685859 | -21,952 | -4,800 | -7,552 | — |
| chr14_69685936_T_C | chr14:69685936 | -21,952 | -4,512 | -9,728 | — |
| chr14_69685819_C_G | chr14:69685819 | -21,888 | -7,584 | -14,848 | — |
| chr14_69685829_T_A | chr14:69685829 | -21,696 | -6,016 | -11,648 | — |
| chr14_69685914_G_T | chr14:69685914 | 21,504 | 5,792 | 7,040 | — |
| chr14_69685883_T_A | chr14:69685883 | -21,376 | -6,240 | -10,752 | — |
| chr14_69685970_A_C | chr14:69685970 | -21,312 | -2,592 | -8,384 | — |
| chr14_69685818_A_C | chr14:69685818 | -21,120 | -5,696 | -11,520 | — |
| chr14_69685875_T_C | chr14:69685875 | 20,992 | 6,624 | 8,576 | — |
| chr14_69685967_G_C | chr14:69685967 | -20,864 | -2,880 | -10,752 | — |
| chr14_69685872_G_T | chr14:69685872 | -20,800 | -5,120 | -14,272 | — |
| chr14_69685884_T_C | chr14:69685884 | -20,800 | -5,792 | -9,600 | — |
| chr14_69685831_T_A | chr14:69685831 | -20,736 | -4,704 | -10,368 | — |
| chr14_69685923_A_T | chr14:69685923 | 20,416 | 3,072 | 10,496 | — |
| chr14_69685820_A_C | chr14:69685820 | -20,352 | -6,048 | -11,264 | — |
| chr14_69685895_C_G | chr14:69685895 | -20,288 | -2,176 | -6,784 | — |
| chr14_69685900_A_C | chr14:69685900 | 20,288 | 5,024 | 9,728 | — |
| chr14_69685860_C_A | chr14:69685860 | 20,160 | 4,992 | 7,168 | — |
| chr14_69685948_G_T | chr14:69685948 | -20,032 | -3,200 | -11,968 | — |
| chr14_69685847_G_A | chr14:69685847 | -19,968 | -5,344 | -14,720 | — |
| chr14_69685973_T_C | chr14:69685973 | -19,968 | -3,072 | -10,240 | — |
| chr14_69685969_C_A | chr14:69685969 | -19,904 | -2,976 | -9,792 | — |
| chr14_69685887_T_G | chr14:69685887 | 19,584 | 4,384 | 9,216 | — |
| chr14_69685842_A_G | chr14:69685842 | -19,520 | -4,768 | -14,720 | — |
| chr14_69685931_C_A | chr14:69685931 | -19,456 | -2,688 | -8,704 | — |
| chr14_69685867_G_C | chr14:69685867 | -19,328 | -5,216 | -11,776 | — |
| chr14_69685855_G_T | chr14:69685855 | -19,200 | -4,608 | -9,600 | — |
| chr14_69685847_G_T | chr14:69685847 | -19,072 | -5,152 | -14,720 | — |
| chr14_69741167_T_A | chr14:69741167 | -19,008 | -5,344 | -17,216 | — |
| chr14_69685880_A_C | chr14:69685880 | -18,944 | -5,920 | -8,448 | — |
| chr14_69685819_C_A | chr14:69685819 | -18,752 | -7,328 | -13,312 | — |
| chr14_69685920_G_A | chr14:69685920 | 18,688 | 4,832 | 12,288 | 2.0e-5 |
| chr14_69685971_G_C | chr14:69685971 | -18,624 | -960 | -8,064 | 6.6e-6 |
| chr14_69685866_T_G | chr14:69685866 | -18,560 | -3,968 | -9,216 | — |
| chr14_69685853_C_A | chr14:69685853 | 18,432 | 4,512 | 10,752 | — |
| chr14_69685871_T_A | chr14:69685871 | 18,368 | 4,544 | 4,992 | — |
| chr14_69685887_T_C | chr14:69685887 | 18,368 | 4,800 | 12,160 | — |
| chr14_69685897_G_A | chr14:69685897 | -18,304 | -5,280 | -9,728 | — |
| chr14_69685838_T_C | chr14:69685838 | 18,240 | 4,160 | 10,496 | — |
| chr14_69685889_C_T | chr14:69685889 | -18,240 | -4,768 | -8,704 | — |
| chr14_69685824_T_G | chr14:69685824 | -18,048 | -6,432 | -11,904 | — |
| chr14_69685869_A_T | chr14:69685869 | -17,984 | -5,280 | -10,752 | — |
| chr14_69685871_T_C | chr14:69685871 | 17,856 | 4,192 | 10,112 | — |
| chr14_69685818_A_T | chr14:69685818 | -17,728 | -4,928 | -9,728 | — |
| chr14_69685855_G_A | chr14:69685855 | -17,728 | -3,616 | -9,472 | 6.6e-6 |
| chr14_69685866_T_A | chr14:69685866 | -17,664 | -3,488 | -7,808 | — |
| chr14_69685872_G_A | chr14:69685872 | -17,536 | -3,296 | -8,320 | — |
| chr14_69685913_A_G | chr14:69685913 | 17,472 | 3,712 | 8,064 | — |
| chr14_69685964_C_A | chr14:69685964 | -17,408 | -2,112 | -9,536 | — |
| chr14_69685864_T_A | chr14:69685864 | -17,280 | -4,256 | -10,624 | — |
| chr14_69685922_G_A | chr14:69685922 | -17,152 | -3,136 | -6,016 | — |
| chr14_69685985_G_T | chr14:69685985 | -17,088 | -2,048 | -7,808 | — |
| chr14_69685819_C_T | chr14:69685819 | -17,024 | -6,080 | -11,264 | — |
| chr14_69685841_T_C | chr14:69685841 | -16,960 | -3,648 | -10,752 | — |
| chr14_69685870_A_T | chr14:69685870 | 16,832 | 3,744 | 7,936 | — |
| chr14_69685941_G_A | chr14:69685941 | 16,640 | 3,040 | 3,840 | — |
| chr14_69685864_T_C | chr14:69685864 | -16,576 | -4,256 | -10,624 | — |
| chr14_69685909_C_A | chr14:69685909 | 16,512 | 3,968 | 9,728 | — |
| chr14_69685924_G_C | chr14:69685924 | 16,512 | 4,480 | 12,544 | — |
| chr14_69685850_A_G | chr14:69685850 | -16,448 | -4,800 | -10,240 | — |
| chr14_69685840_G_C | chr14:69685840 | -16,384 | -4,576 | -14,976 | — |
| chr14_69685865_G_T | chr14:69685865 | -16,256 | -4,096 | -11,136 | — |
| chr14_69685870_A_C | chr14:69685870 | 16,064 | 3,456 | 7,168 | — |
| chr14_69685855_G_C | chr14:69685855 | -16,000 | -3,744 | -8,320 | — |
| chr14_69685921_T_G | chr14:69685921 | 16,000 | 3,008 | 3,968 | — |
| chr14_69685952_A_C | chr14:69685952 | -15,872 | -1,312 | -6,272 | — |
| chr14_69685963_C_G | chr14:69685963 | 15,808 | 960 | 5,376 | — |
| chr14_69685826_T_C | chr14:69685826 | -15,744 | -4,416 | -8,832 | — |
| chr14_69685869_A_G | chr14:69685869 | -15,744 | -2,848 | -5,888 | 1.3e-5 |
| chr14_69685958_A_G | chr14:69685958 | 15,680 | 3,424 | 8,960 | — |
| chr14_69685970_A_G | chr14:69685970 | -15,616 | -2,400 | -7,168 | — |
| chr14_69685897_G_C | chr14:69685897 | 15,424 | 3,520 | 6,144 | — |
| chr14_69685894_G_C | chr14:69685894 | -15,296 | -1,440 | -6,272 | — |
| chr14_69685881_C_A | chr14:69685881 | -15,168 | -3,776 | -3,328 | — |
| chr14_69685896_T_C | chr14:69685896 | 15,168 | 3,008 | 6,272 | — |
| chr14_69685843_A_T | chr14:69685843 | -15,104 | -3,488 | -13,184 | — |
| chr14_69685900_A_T | chr14:69685900 | 15,104 | 3,968 | 11,648 | — |
| chr14_69685865_G_C | chr14:69685865 | -15,040 | -4,032 | -10,112 | — |
| chr14_69685825_G_C | chr14:69685825 | -14,976 | -5,152 | -8,960 | — |
| chr14_69685863_T_A | chr14:69685863 | -14,976 | -3,648 | -5,632 | — |
| chr14_69685841_T_G | chr14:69685841 | -14,912 | -3,616 | -10,624 | — |
| chr14_69685921_T_A | chr14:69685921 | 14,912 | 2,912 | 4,096 | — |
| chr14_69685981_T_G | chr14:69685981 | 14,912 | 192 | 6,016 | — |
| chr14_69685828_C_T | chr14:69685828 | -14,848 | -5,184 | -11,008 | — |
| chr14_69685846_T_A | chr14:69685846 | 14,848 | 3,296 | 5,760 | — |
| chr14_69685856_A_T | chr14:69685856 | 14,656 | 4,064 | 9,088 | — |
| chr14_69685919_C_G | chr14:69685919 | 14,656 | 4,608 | 6,272 | — |
| chr14_69685977_T_G | chr14:69685977 | -14,592 | -640 | -2,688 | — |
| chr14_69685918_T_G | chr14:69685918 | 14,528 | 3,808 | 8,192 | — |
| chr14_69685970_A_T | chr14:69685970 | -14,528 | -1,760 | -6,528 | — |
| chr14_69685902_A_C | chr14:69685902 | 14,464 | 4,800 | 7,680 | — |
| chr14_69685914_G_A | chr14:69685914 | 14,464 | 4,576 | 6,144 | — |
| chr14_69719739_T_A | chr14:69719739 | 3,008 | 2,240 | 16,384 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.