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SLC51A
receptor: FXRTier 1
CAMIP causal chains
FXR
Blunted receptor-mediated induction of SLC51A expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near SLC51A
chr3:196,116,533..196,333,427, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr3_196163877_C_G | chr3:196163877 | 60,800 | 17,600 | 58,624 | — |
| chr3_196163877_C_T | chr3:196163877 | 59,008 | 17,632 | 51,968 | — |
| chr3_196163875_C_T | chr3:196163875 | 58,752 | 16,288 | 59,008 | — |
| chr3_196163875_C_G | chr3:196163875 | 58,688 | 17,376 | 65,152 | — |
| chr3_196163876_C_A | chr3:196163876 | 54,016 | 17,248 | 55,040 | — |
| chr3_196163875_C_A | chr3:196163875 | 53,056 | 16,896 | 57,216 | — |
| chr3_196163876_C_G | chr3:196163876 | 52,672 | 15,232 | 57,088 | — |
| chr3_196163869_T_A | chr3:196163869 | 51,392 | 16,960 | 63,104 | — |
| chr3_196163847_C_T | chr3:196163847 | 50,848 | 22,752 | 57,216 | — |
| chr3_196163874_C_G | chr3:196163874 | 50,176 | 14,848 | 52,480 | — |
| chr3_196163872_A_T | chr3:196163872 | 49,280 | 16,992 | 49,408 | — |
| chr3_196163874_C_T | chr3:196163874 | 47,232 | 12,672 | 47,104 | — |
| chr3_196163873_G_A | chr3:196163873 | 42,176 | 14,176 | 37,632 | — |
| chr3_196163876_C_T | chr3:196163876 | 39,168 | 11,872 | 44,288 | — |
| chr3_196163869_T_G | chr3:196163869 | 39,040 | 13,312 | 52,096 | — |
| chr3_196163873_G_C | chr3:196163873 | 39,040 | 12,864 | 37,632 | — |
| chr3_196163872_A_C | chr3:196163872 | 38,080 | 12,480 | 35,840 | — |
| chr3_196163878_C_A | chr3:196163878 | 33,728 | 11,104 | 39,040 | — |
| chr3_196160291_C_G | chr3:196160291 | 33,088 | 7,392 | 36,480 | — |
| chr3_196163878_C_G | chr3:196163878 | 31,424 | 10,560 | 35,456 | — |
| chr3_196160362_T_C | chr3:196160362 | 27,840 | 9,856 | 24,704 | — |
| chr3_196163877_C_A | chr3:196163877 | 23,936 | 6,816 | 20,224 | — |
| chr3_196160361_T_G | chr3:196160361 | 22,592 | 7,456 | 21,632 | — |
| chr3_196163872_A_G | chr3:196163872 | 22,016 | 7,168 | 24,576 | — |
| chr3_196163898_A_C | chr3:196163898 | -21,600 | -4,096 | 9,344 | — |
| chr3_196163880_G_C | chr3:196163880 | 20,800 | 6,496 | 21,760 | — |
| chr3_196163898_A_T | chr3:196163898 | -20,608 | -8,720 | -33,792 | — |
| chr3_196160287_G_C | chr3:196160287 | 20,224 | 6,144 | 19,584 | — |
| chr3_196163870_G_T | chr3:196163870 | 19,968 | 7,648 | 24,832 | — |
| chr3_196163899_A_C | chr3:196163899 | -19,936 | -9,296 | -33,280 | — |
| chr3_196163897_T_G | chr3:196163897 | -19,904 | -8,768 | -35,328 | — |
| chr3_196163896_A_G | chr3:196163896 | 19,392 | 7,520 | 24,064 | — |
| chr3_196163928_T_G | chr3:196163928 | 19,328 | 9,328 | 21,504 | — |
| chr3_196163870_G_C | chr3:196163870 | 19,200 | 6,944 | 22,016 | — |
| chr3_196163909_T_G | chr3:196163909 | -19,104 | -7,904 | -26,112 | — |
| chr3_196163897_T_A | chr3:196163897 | -18,592 | -7,776 | -27,136 | — |
| chr3_196160351_A_G | chr3:196160351 | 18,560 | 5,856 | 15,360 | — |
| chr3_196163909_T_C | chr3:196163909 | -18,496 | -8,416 | -25,472 | — |
| chr3_196160367_G_C | chr3:196160367 | -18,496 | -6,272 | -18,048 | — |
| chr3_196163909_T_A | chr3:196163909 | -18,304 | -8,000 | -27,008 | — |
| chr3_196163899_A_G | chr3:196163899 | -17,920 | -8,720 | -29,696 | — |
| chr3_196160360_A_G | chr3:196160360 | 17,792 | 6,688 | 19,072 | — |
| chr3_196163851_A_G | chr3:196163851 | 17,728 | 8,544 | 23,808 | — |
| chr3_196163899_A_T | chr3:196163899 | -17,568 | -8,576 | -32,384 | — |
| chr3_196160291_C_T | chr3:196160291 | 17,280 | 4,448 | 23,040 | — |
| chr3_196160325_C_A | chr3:196160325 | -17,280 | -2,112 | -11,520 | — |
| chr3_196163859_A_G | chr3:196163859 | -17,216 | -5,920 | -24,448 | — |
| chr3_196163907_G_C | chr3:196163907 | 17,024 | 1,504 | 28,160 | — |
| chr3_196160338_A_T | chr3:196160338 | 16,960 | 6,400 | 15,104 | — |
| chr3_196163906_A_T | chr3:196163906 | -16,896 | -7,520 | -22,144 | — |
| chr3_196160282_G_T | chr3:196160282 | 16,896 | 2,368 | 10,112 | — |
| chr3_196163893_T_A | chr3:196163893 | -16,608 | -7,200 | -30,336 | — |
| chr3_196163912_G_T | chr3:196163912 | 16,384 | 5,376 | 25,600 | — |
| chr3_196163942_C_G | chr3:196163942 | 16,384 | 6,912 | 19,200 | — |
| chr3_196160269_C_A | chr3:196160269 | -16,320 | -5,376 | -16,896 | — |
| chr3_196160357_A_C | chr3:196160357 | -16,256 | -5,024 | -17,920 | — |
| chr3_196160367_G_A | chr3:196160367 | -16,192 | -5,760 | -17,920 | — |
| chr3_196163873_G_T | chr3:196163873 | 16,128 | 4,544 | 16,128 | — |
| chr3_196163893_T_G | chr3:196163893 | -16,096 | -6,576 | -28,288 | — |
| chr3_196163939_C_G | chr3:196163939 | 16,064 | 5,216 | 16,128 | — |
| chr3_196163893_T_C | chr3:196163893 | -15,424 | -6,864 | -30,848 | — |
| chr3_196163894_G_C | chr3:196163894 | -15,296 | -6,848 | -33,664 | — |
| chr3_196163879_G_C | chr3:196163879 | -15,232 | -6,080 | -24,704 | — |
| chr3_196163878_C_T | chr3:196163878 | 15,232 | 4,864 | 17,280 | — |
| chr3_196160292_C_G | chr3:196160292 | 14,976 | 5,376 | 23,808 | — |
| chr3_196163841_G_C | chr3:196163841 | 14,976 | 3,136 | 9,984 | — |
| chr3_196160269_C_T | chr3:196160269 | -14,912 | -4,768 | -15,360 | — |
| chr3_196163895_C_G | chr3:196163895 | -14,848 | -7,056 | -35,200 | — |
| chr3_196160269_C_G | chr3:196160269 | -14,848 | -4,992 | -14,976 | — |
| chr3_196163895_C_T | chr3:196163895 | -14,784 | -6,512 | -31,872 | — |
| chr3_196163863_G_C | chr3:196163863 | 14,784 | 5,504 | 21,504 | — |
| chr3_196163905_G_C | chr3:196163905 | -14,720 | -5,376 | -19,840 | — |
| chr3_196160357_A_T | chr3:196160357 | -14,720 | -4,608 | -18,048 | — |
| chr3_196160349_A_T | chr3:196160349 | -14,656 | -4,256 | -14,848 | — |
| chr3_196160356_C_G | chr3:196160356 | -14,656 | -4,448 | -14,848 | — |
| chr3_196160317_C_G | chr3:196160317 | -14,656 | -3,296 | -11,264 | — |
| chr3_196160355_A_T | chr3:196160355 | -14,528 | -4,192 | -17,536 | — |
| chr3_196163896_A_T | chr3:196163896 | -14,368 | -6,256 | -26,368 | — |
| chr3_196163898_A_G | chr3:196163898 | -14,304 | -5,568 | -30,976 | — |
| chr3_196163896_A_C | chr3:196163896 | -14,272 | -6,352 | -22,784 | — |
| chr3_196163906_A_C | chr3:196163906 | -14,272 | -6,656 | -18,560 | — |
| chr3_196160263_C_A | chr3:196160263 | -14,272 | -5,280 | -15,360 | — |
| chr3_196160289_C_A | chr3:196160289 | -14,272 | -4,608 | -15,232 | — |
| chr3_196160349_A_C | chr3:196160349 | -14,208 | -3,776 | -11,904 | — |
| chr3_196163895_C_A | chr3:196163895 | -14,016 | -6,608 | -33,280 | — |
| chr3_196163881_G_C | chr3:196163881 | -13,952 | -5,632 | -18,304 | — |
| chr3_196163874_C_A | chr3:196163874 | -13,760 | -4,736 | -20,480 | — |
| chr3_196160357_A_G | chr3:196160357 | -13,696 | -3,648 | -14,208 | — |
| chr3_196160353_A_T | chr3:196160353 | -13,568 | -3,968 | -13,568 | — |
| chr3_196163894_G_T | chr3:196163894 | -13,472 | -5,536 | -24,192 | — |
| chr3_196163906_A_G | chr3:196163906 | -13,440 | -4,672 | -25,088 | — |
| chr3_196163907_G_A | chr3:196163907 | -13,440 | -5,504 | -14,976 | — |
| chr3_196160356_C_A | chr3:196160356 | -13,376 | -4,480 | -15,360 | — |
| chr3_196163902_C_G | chr3:196163902 | 13,184 | 1,696 | 18,688 | — |
| chr3_196163950_C_G | chr3:196163950 | 12,736 | 3,328 | 13,824 | — |
| chr3_196160367_G_T | chr3:196160367 | -12,736 | -4,384 | -13,568 | — |
| chr3_196163931_C_T | chr3:196163931 | 12,480 | 5,344 | 15,104 | — |
| chr3_196163911_A_T | chr3:196163911 | -12,320 | -5,840 | -24,320 | — |
| chr3_196163942_C_A | chr3:196163942 | 12,224 | 4,800 | 13,824 | — |
| chr3_196160329_G_T | chr3:196160329 | -12,160 | -3,840 | -12,416 | — |
| chr3_196160293_C_G | chr3:196160293 | 12,096 | 4,288 | 16,000 | — |
| chr3_196160351_A_T | chr3:196160351 | -12,032 | -3,680 | -12,288 | — |
| chr3_196160368_G_C | chr3:196160368 | -12,032 | -4,224 | -11,520 | — |
| chr3_196163911_A_C | chr3:196163911 | -11,936 | -6,112 | -24,832 | — |
| chr3_196163842_C_T | chr3:196163842 | -11,872 | -2,400 | -11,136 | — |
| chr3_196163959_A_C | chr3:196163959 | 11,840 | 6,144 | 12,032 | — |
| chr3_196163910_C_A | chr3:196163910 | -11,840 | -3,584 | -4,480 | — |
| chr3_196163910_C_T | chr3:196163910 | -11,776 | -5,120 | -20,736 | — |
| chr3_196160327_C_A | chr3:196160327 | -11,776 | -3,584 | -7,296 | — |
| chr3_196163847_C_G | chr3:196163847 | 11,680 | 4,768 | 14,720 | — |
| chr3_196160332_A_T | chr3:196160332 | 11,648 | 5,504 | 17,152 | — |
| chr3_196160361_T_C | chr3:196160361 | 11,648 | 3,712 | 11,136 | — |
| chr3_196163844_G_C | chr3:196163844 | 11,648 | 3,712 | 11,264 | — |
| chr3_196160355_A_G | chr3:196160355 | -11,584 | -3,200 | -12,160 | — |
| chr3_196160270_T_A | chr3:196160270 | -11,520 | -5,088 | -16,128 | — |
| chr3_196160345_A_G | chr3:196160345 | 11,520 | 2,560 | 5,376 | — |
| chr3_196163871_C_A | chr3:196163871 | -11,328 | -2,944 | -13,696 | — |
| chr3_196163905_G_A | chr3:196163905 | -11,136 | -3,072 | -19,456 | — |
| chr3_196160325_C_G | chr3:196160325 | -11,136 | -2,752 | -11,648 | — |
| chr3_196160353_A_G | chr3:196160353 | -11,072 | -3,104 | -11,904 | — |
| chr3_196163969_G_T | chr3:196163969 | 10,944 | 6,016 | 12,544 | — |
| chr3_196160263_C_T | chr3:196160263 | -10,944 | -3,808 | -11,520 | — |
| chr3_196163973_C_T | chr3:196163973 | 10,816 | 4,064 | 13,568 | — |
| chr3_196160243_C_A | chr3:196160243 | 10,752 | 5,344 | 25,088 | — |
| chr3_196160354_A_T | chr3:196160354 | -10,688 | -3,328 | -13,568 | — |
| chr3_196160343_G_T | chr3:196160343 | -10,688 | -2,688 | -8,448 | — |
| chr3_196163911_A_G | chr3:196163911 | -10,528 | -5,248 | -19,328 | — |
| chr3_196163910_C_G | chr3:196163910 | -10,528 | -4,192 | -16,000 | — |
| chr3_196163861_C_A | chr3:196163861 | -10,496 | -4,288 | -18,304 | — |
| chr3_196160354_A_G | chr3:196160354 | -10,304 | -2,912 | -11,776 | — |
| chr3_196160324_A_C | chr3:196160324 | -10,240 | -3,264 | -10,880 | — |
| chr3_196160355_A_C | chr3:196160355 | -10,240 | -512 | -8,192 | — |
| chr3_196163900_C_A | chr3:196163900 | -9,984 | -4,880 | -14,848 | — |
| chr3_196160321_G_T | chr3:196160321 | -9,984 | -2,784 | -8,448 | — |
| chr3_196163974_C_G | chr3:196163974 | 9,792 | 3,472 | 14,848 | — |
| chr3_196160321_G_A | chr3:196160321 | -9,792 | -2,848 | -8,704 | — |
| chr3_196163840_G_C | chr3:196163840 | -9,664 | -3,776 | -16,128 | — |
| chr3_196160267_T_G | chr3:196160267 | 9,664 | 3,104 | 11,008 | — |
| chr3_196163908_G_A | chr3:196163908 | -9,568 | -4,352 | -12,160 | — |
| chr3_196163892_T_G | chr3:196163892 | -9,408 | -3,936 | -22,400 | — |
| chr3_196160364_A_C | chr3:196160364 | 9,408 | 3,840 | 13,824 | — |
| chr3_196163904_T_C | chr3:196163904 | -9,344 | -3,488 | -15,616 | — |
| chr3_196160366_A_T | chr3:196160366 | -9,152 | -3,616 | -10,112 | — |
| chr3_196163891_G_T | chr3:196163891 | -9,024 | -4,224 | -21,376 | — |
| chr3_196163892_T_C | chr3:196163892 | -8,992 | -4,416 | -20,224 | — |
| chr3_196160270_T_G | chr3:196160270 | -8,896 | -4,256 | -10,496 | — |
| chr3_196160303_G_T | chr3:196160303 | -8,832 | -2,240 | -10,240 | — |
| chr3_196163879_G_A | chr3:196163879 | -8,768 | -2,944 | -9,856 | — |
| chr3_196160352_T_G | chr3:196160352 | -8,640 | -2,976 | -10,752 | — |
| chr3_196163855_T_G | chr3:196163855 | -8,576 | -3,760 | -15,616 | — |
| chr3_196163947_G_C | chr3:196163947 | 8,384 | 3,168 | 12,544 | — |
| chr3_196160251_T_G | chr3:196160251 | 8,384 | 3,360 | 11,264 | — |
| chr3_196163865_T_C | chr3:196163865 | -8,384 | -1,696 | -11,008 | — |
| chr3_196163880_G_T | chr3:196163880 | 8,384 | 2,560 | 10,240 | — |
| chr3_196163908_G_C | chr3:196163908 | -8,192 | -4,384 | -9,856 | — |
| chr3_196163908_G_T | chr3:196163908 | -8,128 | -4,096 | -15,232 | — |
| chr3_196160341_G_C | chr3:196160341 | 8,064 | 3,328 | 11,904 | — |
| chr3_196160311_G_C | chr3:196160311 | -8,064 | -2,272 | -9,856 | — |
| chr3_196163892_T_A | chr3:196163892 | -7,872 | -4,464 | -20,864 | — |
| chr3_196163866_C_T | chr3:196163866 | 7,808 | 3,040 | 17,792 | — |
| chr3_196160356_C_T | chr3:196160356 | -7,744 | -2,656 | -10,624 | — |
| chr3_196160293_C_A | chr3:196160293 | 7,488 | 3,040 | 11,520 | — |
| chr3_196160267_T_C | chr3:196160267 | -7,360 | -2,784 | -11,392 | — |
| chr3_196163935_C_A | chr3:196163935 | -7,296 | -2,128 | -10,624 | — |
| chr3_196163949_G_T | chr3:196163949 | -7,232 | -3,200 | -16,000 | — |
| chr3_196160337_A_G | chr3:196160337 | 7,232 | 2,656 | 11,264 | — |
| chr3_196163891_G_A | chr3:196163891 | 7,168 | 2,272 | 10,752 | — |
| chr3_196163840_G_A | chr3:196163840 | -7,104 | -2,688 | -10,880 | — |
| chr3_196163847_C_A | chr3:196163847 | 7,072 | 2,976 | 11,904 | — |
| chr3_196163879_G_T | chr3:196163879 | -7,040 | -3,264 | -12,544 | — |
| chr3_196163839_A_C | chr3:196163839 | -7,040 | -2,464 | -9,856 | — |
| chr3_196163973_C_A | chr3:196163973 | 6,848 | 3,008 | 10,240 | — |
| chr3_196163840_G_T | chr3:196163840 | -6,848 | -2,688 | -9,856 | — |
| chr3_196160292_C_T | chr3:196160292 | 6,784 | 1,888 | 10,368 | — |
| chr3_196163972_C_T | chr3:196163972 | 6,784 | 2,432 | 9,984 | — |
| chr3_196163905_G_T | chr3:196163905 | -6,592 | -2,336 | -11,776 | — |
| chr3_196160268_C_T | chr3:196160268 | -6,336 | -3,360 | -10,752 | — |
| chr3_196163853_A_G | chr3:196163853 | -6,336 | -3,488 | -10,496 | — |
| chr3_196163975_A_C | chr3:196163975 | -6,048 | -2,640 | -14,336 | — |
| chr3_196163894_G_A | chr3:196163894 | -5,728 | -2,240 | -14,976 | — |
| chr3_196163975_A_T | chr3:196163975 | -5,696 | -2,384 | -12,544 | — |
| chr3_196163912_G_A | chr3:196163912 | -5,440 | -1,920 | -14,720 | — |
| chr3_196163972_C_G | chr3:196163972 | 5,312 | 2,304 | 13,056 | — |
| chr3_196163853_A_T | chr3:196163853 | -5,312 | -2,560 | -11,136 | — |
| chr3_196163924_G_T | chr3:196163924 | 5,312 | 2,656 | 10,112 | — |
| chr3_196163904_T_A | chr3:196163904 | -5,248 | -832 | -11,520 | — |
| chr3_196163913_C_G | chr3:196163913 | -5,248 | -2,112 | -9,984 | — |
| chr3_196163903_A_T | chr3:196163903 | -5,056 | -512 | -12,544 | — |
| chr3_196160338_A_G | chr3:196160338 | 4,992 | 2,880 | 14,720 | — |
| chr3_196160346_A_G | chr3:196160346 | 4,864 | 3,744 | 9,984 | — |
| chr3_196163972_C_A | chr3:196163972 | 4,416 | 2,272 | 11,520 | — |
| chr3_196163946_G_A | chr3:196163946 | 4,352 | 1,952 | 17,408 | — |
| chr3_196163842_C_G | chr3:196163842 | -4,032 | -672 | -13,056 | — |
| chr3_196163925_C_A | chr3:196163925 | 3,904 | 1,792 | 10,624 | — |
| chr3_196163903_A_C | chr3:196163903 | -3,840 | 0 | -10,368 | — |
| chr3_196163946_G_T | chr3:196163946 | 1,856 | 928 | 10,240 | — |
| chr3_196163970_G_C | chr3:196163970 | 1,408 | 2,496 | 11,776 | — |
| chr3_196163961_C_T | chr3:196163961 | 1,280 | 960 | 9,984 | — |
| chr3_196163963_C_G | chr3:196163963 | 832 | 1,888 | 11,008 | — |
| chr3_196163862_T_C | chr3:196163862 | -256 | 64 | 10,368 | — |
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