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SLC51B
receptor: FXRTier 1
CAMIP causal chains
FXR
Blunted receptor-mediated induction of SLC51B expression, reducing heteromeric basolateral bile acid efflux capacity in hepatocytes and enterocytes.
Affected substrate drugs (PharmGKB): none in routine clinical use, endogenous or bile acid pathway
Scored variants near SLC51B
chr15:64,945,386..65,153,397, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr15_64982020_C_A | chr15:64982020 | -96,288 | -37,056 | -58,240 | — |
| chr15_64982024_G_A | chr15:64982024 | -89,408 | -35,104 | -55,936 | — |
| chr15_64982022_A_C | chr15:64982022 | -89,312 | -35,072 | -52,288 | — |
| chr15_64982022_A_T | chr15:64982022 | -85,760 | -33,344 | -49,920 | — |
| chr15_64982024_G_C | chr15:64982024 | -81,792 | -31,968 | -48,896 | — |
| chr15_64982020_C_G | chr15:64982020 | -77,536 | -28,896 | -43,264 | — |
| chr15_64982022_A_G | chr15:64982022 | -74,912 | -28,800 | -41,344 | 6.6e-6 |
| chr15_64982021_A_T | chr15:64982021 | -73,888 | -29,632 | -48,896 | — |
| chr15_64982027_C_A | chr15:64982027 | -69,024 | -27,872 | -51,392 | — |
| chr15_64982027_C_G | chr15:64982027 | -68,512 | -27,712 | -50,048 | — |
| chr15_64982028_A_C | chr15:64982028 | -67,552 | -25,216 | -35,712 | — |
| chr15_64982024_G_T | chr15:64982024 | -66,624 | -27,072 | -41,728 | — |
| chr15_64982025_T_A | chr15:64982025 | -65,344 | -27,296 | -47,424 | — |
| chr15_64982025_T_C | chr15:64982025 | -64,960 | -27,328 | -46,400 | 6.6e-6 |
| chr15_64982026_C_G | chr15:64982026 | -64,224 | -23,904 | -35,072 | — |
| chr15_64982020_C_T | chr15:64982020 | -64,000 | -23,808 | -33,024 | — |
| chr15_64982023_A_C | chr15:64982023 | -63,616 | -25,408 | -45,440 | — |
| chr15_64982023_A_T | chr15:64982023 | -62,144 | -24,640 | -44,480 | — |
| chr15_64982025_T_G | chr15:64982025 | -60,448 | -24,928 | -41,024 | — |
| chr15_64982027_C_T | chr15:64982027 | -59,744 | -23,616 | -42,496 | — |
| chr15_64982044_T_G | chr15:64982044 | 57,664 | 21,920 | 20,480 | — |
| chr15_64982026_C_A | chr15:64982026 | -57,504 | -21,920 | -30,976 | — |
| chr15_64982028_A_T | chr15:64982028 | -56,672 | -20,800 | -28,160 | — |
| chr15_64982018_G_C | chr15:64982018 | -56,352 | -20,800 | -32,256 | — |
| chr15_64982023_A_G | chr15:64982023 | -55,904 | -21,856 | -39,168 | — |
| chr15_64982007_A_C | chr15:64982007 | 53,024 | 17,728 | 21,248 | — |
| chr15_64981991_A_G | chr15:64981991 | 52,096 | 18,368 | 26,112 | — |
| chr15_64982021_A_G | chr15:64982021 | -51,392 | -19,648 | -28,672 | — |
| chr15_64981991_A_C | chr15:64981991 | 48,704 | 19,424 | 19,968 | — |
| chr15_64981989_G_A | chr15:64981989 | 47,488 | 15,872 | 17,152 | — |
| chr15_64981985_A_T | chr15:64981985 | -43,040 | -17,376 | -23,936 | — |
| chr15_64982017_A_G | chr15:64982017 | 42,816 | 12,896 | 19,712 | — |
| chr15_64982050_T_A | chr15:64982050 | -42,624 | -16,768 | -22,912 | — |
| chr15_64981933_G_A | chr15:64981933 | 42,240 | 16,352 | 14,080 | — |
| chr15_64982060_C_A | chr15:64982060 | 41,568 | 16,992 | 12,160 | — |
| chr15_64982021_A_C | chr15:64982021 | -40,672 | -16,064 | -22,528 | — |
| chr15_64981985_A_C | chr15:64981985 | -38,464 | -15,392 | -18,944 | — |
| chr15_64982017_A_C | chr15:64982017 | -37,536 | -14,080 | -22,528 | — |
| chr15_64982011_G_A | chr15:64982011 | 35,840 | 12,320 | 16,384 | — |
| chr15_64981996_T_G | chr15:64981996 | 35,136 | 13,184 | 16,000 | — |
| chr15_64982044_T_A | chr15:64982044 | 35,136 | 14,976 | 12,544 | — |
| chr15_64981970_A_C | chr15:64981970 | -34,944 | -11,168 | -14,336 | — |
| chr15_64982008_A_T | chr15:64982008 | -34,368 | -12,768 | -17,536 | — |
| chr15_64982049_T_A | chr15:64982049 | -34,176 | -14,944 | -22,272 | — |
| chr15_64982004_G_T | chr15:64982004 | -33,888 | -11,808 | -13,184 | — |
| chr15_64982051_G_A | chr15:64982051 | -33,792 | -13,536 | -19,200 | — |
| chr15_64982050_T_G | chr15:64982050 | -33,728 | -12,288 | -16,896 | — |
| chr15_64981942_T_C | chr15:64981942 | -33,664 | -9,600 | -11,648 | — |
| chr15_64982026_C_T | chr15:64982026 | -33,664 | -11,104 | -17,792 | — |
| chr15_64982018_G_A | chr15:64982018 | -32,992 | -11,616 | -17,280 | — |
| chr15_64982016_A_C | chr15:64982016 | -32,256 | -11,968 | -14,976 | — |
| chr15_64981958_G_T | chr15:64981958 | -31,360 | -10,400 | -11,392 | — |
| chr15_64981963_T_G | chr15:64981963 | -30,976 | -11,616 | -20,352 | — |
| chr15_64982018_G_T | chr15:64982018 | -30,688 | -10,944 | -17,536 | — |
| chr15_64982017_A_T | chr15:64982017 | -30,080 | -10,752 | -17,408 | — |
| chr15_64982048_T_C | chr15:64982048 | -29,952 | -11,712 | -14,592 | — |
| chr15_64981956_C_T | chr15:64981956 | -29,696 | -8,800 | -9,472 | — |
| chr15_64981960_G_A | chr15:64981960 | 29,440 | 800 | 7,040 | — |
| chr15_64982051_G_T | chr15:64982051 | -29,056 | -11,392 | -15,488 | — |
| chr15_64981983_T_G | chr15:64981983 | -28,640 | -10,688 | -13,312 | — |
| chr15_64982033_G_T | chr15:64982033 | -28,576 | -10,656 | -18,048 | — |
| chr15_64982053_A_G | chr15:64982053 | -28,544 | -12,096 | -14,464 | — |
| chr15_64982008_A_C | chr15:64982008 | -27,744 | -9,888 | -14,080 | — |
| chr15_64981988_G_A | chr15:64981988 | -27,616 | -9,760 | -13,312 | — |
| chr15_64982051_G_C | chr15:64982051 | -27,552 | -10,880 | -12,672 | — |
| chr15_64982011_G_T | chr15:64982011 | 27,456 | 9,376 | 12,544 | — |
| chr15_64982008_A_G | chr15:64982008 | -27,264 | -9,760 | -13,824 | — |
| chr15_64982060_C_T | chr15:64982060 | -27,264 | -10,656 | -14,080 | — |
| chr15_64982045_C_T | chr15:64982045 | -26,528 | -10,464 | -14,848 | — |
| chr15_64982006_T_A | chr15:64982006 | -26,304 | -7,296 | -10,240 | — |
| chr15_64981955_T_C | chr15:64981955 | 26,240 | 3,616 | 9,856 | — |
| chr15_64982038_A_T | chr15:64982038 | -26,016 | -8,480 | -11,520 | — |
| chr15_64981962_G_A | chr15:64981962 | -25,984 | -8,736 | -10,496 | 6.6e-6 |
| chr15_64981980_G_C | chr15:64981980 | -25,984 | -10,944 | -8,576 | — |
| chr15_64981988_G_T | chr15:64981988 | 25,792 | 8,896 | 9,728 | — |
| chr15_64981957_T_G | chr15:64981957 | -25,568 | -8,672 | -11,264 | — |
| chr15_64981993_C_G | chr15:64981993 | 25,472 | 8,864 | 13,056 | — |
| chr15_64982045_C_A | chr15:64982045 | 25,120 | 11,744 | 11,904 | — |
| chr15_64982047_C_T | chr15:64982047 | -24,992 | -10,240 | -15,616 | — |
| chr15_64982048_T_A | chr15:64982048 | -24,768 | -10,784 | -12,544 | — |
| chr15_64982084_T_A | chr15:64982084 | 24,640 | 9,568 | 10,240 | — |
| chr15_64982050_T_C | chr15:64982050 | -24,608 | -9,664 | -10,496 | — |
| chr15_64981961_G_A | chr15:64981961 | -24,416 | -8,224 | -12,928 | — |
| chr15_64982058_C_G | chr15:64982058 | 24,416 | 8,512 | 10,368 | — |
| chr15_64981968_G_T | chr15:64981968 | -24,192 | -6,880 | -10,496 | — |
| chr15_64981964_G_C | chr15:64981964 | -24,064 | -4,832 | -7,680 | 1.3e-5 |
| chr15_64982040_C_G | chr15:64982040 | -24,064 | -8,192 | -12,160 | — |
| chr15_64982053_A_T | chr15:64982053 | -23,776 | -10,144 | -11,392 | — |
| chr15_64982052_G_C | chr15:64982052 | -23,584 | -9,920 | -9,856 | — |
| chr15_64981958_G_A | chr15:64981958 | -23,552 | -8,384 | -9,984 | — |
| chr15_64982019_G_A | chr15:64982019 | -23,488 | -7,648 | -13,184 | 2.0e-5 |
| chr15_64981980_G_T | chr15:64981980 | -23,360 | -9,760 | -7,552 | — |
| chr15_64981978_C_G | chr15:64981978 | -23,296 | -8,320 | -8,960 | — |
| chr15_64981994_A_C | chr15:64981994 | -22,912 | -7,168 | -8,448 | — |
| chr15_64981959_T_G | chr15:64981959 | -22,432 | -6,784 | -11,008 | — |
| chr15_64982016_A_T | chr15:64982016 | -22,432 | -8,512 | -11,136 | — |
| chr15_64982064_T_A | chr15:64982064 | -22,048 | -9,920 | -9,856 | — |
| chr15_64981964_G_A | chr15:64981964 | -21,696 | -5,568 | -8,064 | — |
| chr15_64982042_G_C | chr15:64982042 | -21,600 | -7,520 | -10,368 | — |
| chr15_64982002_C_A | chr15:64982002 | -21,536 | -6,912 | -9,984 | — |
| chr15_64981972_A_C | chr15:64981972 | -21,504 | -6,048 | -4,864 | — |
| chr15_64981984_C_A | chr15:64981984 | -21,184 | -9,312 | -8,320 | 2.0e-5 |
| chr15_64981987_T_A | chr15:64981987 | -21,152 | -7,456 | -10,496 | — |
| chr15_64982004_G_C | chr15:64982004 | -20,864 | -7,136 | -8,192 | — |
| chr15_64982003_A_G | chr15:64982003 | -20,832 | -7,040 | -10,240 | — |
| chr15_64982085_C_A | chr15:64982085 | -20,800 | -8,320 | -11,648 | — |
| chr15_64982042_G_A | chr15:64982042 | -20,768 | -8,064 | -12,288 | — |
| chr15_64982062_G_A | chr15:64982062 | -20,352 | -8,576 | -10,624 | 1.3e-5 |
| chr15_64981994_A_T | chr15:64981994 | -20,288 | -6,784 | -8,192 | — |
| chr15_64982055_T_A | chr15:64982055 | -19,648 | -8,000 | -12,288 | — |
| chr15_64982006_T_G | chr15:64982006 | -19,584 | -5,472 | -8,064 | — |
| chr15_64981949_T_C | chr15:64981949 | 19,392 | 4,704 | 7,680 | — |
| chr15_64981987_T_G | chr15:64981987 | -19,200 | -6,048 | -8,192 | — |
| chr15_64982072_G_C | chr15:64982072 | 19,104 | 7,712 | 7,936 | — |
| chr15_64981990_C_G | chr15:64981990 | 19,008 | 7,616 | 7,424 | — |
| chr15_64981960_G_C | chr15:64981960 | -18,944 | -5,248 | -5,632 | — |
| chr15_64981971_C_A | chr15:64981971 | 18,624 | 7,296 | 7,168 | — |
| chr15_64982071_T_G | chr15:64982071 | 18,592 | 7,648 | 9,728 | — |
| chr15_64981951_T_C | chr15:64981951 | 18,560 | 1,920 | 7,680 | 6.6e-6 |
| chr15_64981940_A_T | chr15:64981940 | -18,368 | -5,056 | -6,400 | — |
| chr15_64982040_C_T | chr15:64982040 | -18,304 | -6,944 | -9,984 | — |
| chr15_64982001_G_T | chr15:64982001 | 18,144 | 5,248 | 5,760 | — |
| chr15_64982066_A_T | chr15:64982066 | -18,112 | -7,520 | -8,960 | — |
| chr15_64981973_C_T | chr15:64981973 | 17,984 | 8,384 | 5,888 | — |
| chr15_64982069_G_T | chr15:64982069 | -17,984 | -7,168 | -10,240 | — |
| chr15_64982019_G_T | chr15:64982019 | 17,696 | 6,560 | 6,784 | 6.6e-6 |
| chr15_64981985_A_G | chr15:64981985 | -17,632 | -6,912 | -5,504 | — |
| chr15_64982007_A_G | chr15:64982007 | -17,440 | -6,336 | -10,880 | — |
| chr15_64982047_C_A | chr15:64982047 | -17,312 | -7,360 | -10,496 | — |
| chr15_64982059_A_T | chr15:64982059 | -17,280 | -6,048 | -9,344 | — |
| chr15_64982080_T_G | chr15:64982080 | 17,216 | 4,480 | 5,248 | 6.6e-6 |
| chr15_64981991_A_T | chr15:64981991 | 17,088 | 7,104 | 8,064 | — |
| chr15_64982071_T_C | chr15:64982071 | 17,024 | 6,368 | 9,472 | — |
| chr15_64982117_C_G | chr15:64982117 | 17,024 | 5,984 | 8,960 | — |
| chr15_64982065_C_A | chr15:64982065 | -16,960 | -7,808 | -9,344 | — |
| chr15_64981966_C_G | chr15:64981966 | -16,896 | -4,064 | -7,296 | — |
| chr15_64981983_T_A | chr15:64981983 | -16,768 | -7,584 | -7,424 | — |
| chr15_64981959_T_A | chr15:64981959 | -16,704 | -5,568 | -7,936 | — |
| chr15_64981995_C_A | chr15:64981995 | 16,544 | 5,696 | 7,936 | — |
| chr15_64982035_C_T | chr15:64982035 | -16,448 | -5,664 | -10,112 | — |
| chr15_64982033_G_A | chr15:64982033 | -16,288 | -5,632 | -9,344 | — |
| chr15_64982032_A_G | chr15:64982032 | -16,160 | -4,608 | -7,296 | — |
| chr15_64981984_C_G | chr15:64981984 | -16,064 | -6,912 | -3,072 | — |
| chr15_64982010_T_C | chr15:64982010 | 16,064 | 6,496 | 7,552 | 6.6e-6 |
| chr15_64982036_C_A | chr15:64982036 | -16,064 | -5,408 | -6,784 | — |
| chr15_64981970_A_G | chr15:64981970 | -16,000 | -5,600 | -4,736 | — |
| chr15_64982070_A_C | chr15:64982070 | 16,000 | 5,632 | 6,144 | — |
| chr15_64982080_T_C | chr15:64982080 | 16,000 | 4,736 | 7,552 | — |
| chr15_64982072_G_T | chr15:64982072 | 15,744 | 5,664 | 5,504 | — |
| chr15_64981929_C_G | chr15:64981929 | -15,680 | -4,960 | -6,528 | — |
| chr15_64982054_C_T | chr15:64982054 | -15,680 | -7,232 | -5,760 | — |
| chr15_64981982_G_A | chr15:64981982 | -15,616 | -7,488 | -6,528 | 1.3e-5 |
| chr15_64981998_G_C | chr15:64981998 | 15,552 | 6,048 | 7,168 | — |
| chr15_64982065_C_T | chr15:64982065 | -15,520 | -7,104 | -9,728 | — |
| chr15_64982032_A_C | chr15:64982032 | 15,392 | 5,344 | 9,088 | — |
| chr15_64982096_G_C | chr15:64982096 | -15,232 | -5,664 | -8,960 | — |
| chr15_64982061_A_T | chr15:64982061 | -15,200 | -6,880 | -8,320 | — |
| chr15_64982071_T_A | chr15:64982071 | 14,848 | 6,400 | 7,936 | — |
| chr15_64982110_T_C | chr15:64982110 | -14,784 | -4,896 | -8,064 | — |
| chr15_64981965_G_A | chr15:64981965 | -14,656 | -4,064 | -4,608 | — |
| chr15_64981983_T_C | chr15:64981983 | -14,656 | -6,496 | -4,992 | — |
| chr15_64981968_G_C | chr15:64981968 | -14,464 | -3,744 | -4,480 | — |
| chr15_64981961_G_C | chr15:64981961 | -14,368 | -4,288 | -3,840 | — |
| chr15_64982054_C_G | chr15:64982054 | -14,304 | -5,600 | -6,400 | — |
| chr15_64981939_G_A | chr15:64981939 | 14,272 | 5,760 | 5,120 | — |
| chr15_64982084_T_G | chr15:64982084 | 13,920 | 5,120 | 6,912 | — |
| chr15_64981960_G_T | chr15:64981960 | -13,888 | -4,672 | -4,992 | — |
| chr15_64981961_G_T | chr15:64981961 | -13,856 | -4,352 | -4,992 | — |
| chr15_64981980_G_A | chr15:64981980 | 13,824 | 4,288 | 4,352 | — |
| chr15_64981996_T_A | chr15:64981996 | -13,792 | -4,096 | -4,224 | — |
| chr15_64982029_G_C | chr15:64982029 | 13,792 | 4,448 | 6,784 | — |
| chr15_64981952_C_G | chr15:64981952 | -13,760 | -3,328 | -5,248 | — |
| chr15_64981988_G_C | chr15:64981988 | -13,760 | -4,256 | -6,016 | — |
| chr15_64982055_T_C | chr15:64982055 | -13,760 | -5,504 | -8,064 | — |
| chr15_64981977_C_A | chr15:64981977 | 13,696 | 5,088 | 7,296 | — |
| chr15_64982006_T_C | chr15:64982006 | -13,696 | -4,064 | -5,760 | — |
| chr15_64982046_C_T | chr15:64982046 | -13,696 | -5,984 | -7,040 | 1.3e-5 |
| chr15_64981956_C_A | chr15:64981956 | -13,632 | -3,488 | -4,608 | — |
| chr15_64981973_C_G | chr15:64981973 | 13,632 | 4,256 | 5,248 | — |
| chr15_64981987_T_C | chr15:64981987 | -13,632 | -4,672 | -6,016 | — |
| chr15_64982112_T_C | chr15:64982112 | 13,632 | 5,952 | 7,296 | — |
| chr15_64982015_C_T | chr15:64982015 | -13,568 | -5,152 | -8,576 | — |
| chr15_64982085_C_G | chr15:64982085 | -13,440 | -4,512 | -5,888 | — |
| chr15_64981997_A_G | chr15:64981997 | 13,280 | 5,152 | 6,400 | — |
| chr15_64981963_T_C | chr15:64981963 | 13,120 | 6,208 | 6,400 | — |
| chr15_64981999_G_C | chr15:64981999 | 13,024 | 4,192 | 6,144 | 1.3e-5 |
| chr15_64982086_T_G | chr15:64982086 | 12,800 | 4,320 | 7,936 | — |
| chr15_64982015_C_G | chr15:64982015 | -12,768 | -4,736 | -6,784 | 6.6e-6 |
| chr15_64982049_T_C | chr15:64982049 | -12,736 | -5,824 | -7,040 | 6.6e-6 |
| chr15_64982005_A_C | chr15:64982005 | -12,512 | -4,192 | -5,248 | — |
| chr15_64982029_G_A | chr15:64982029 | 12,512 | 5,152 | 5,376 | — |
| chr15_64981951_T_G | chr15:64981951 | -12,448 | -4,000 | -5,504 | — |
| chr15_64982066_A_C | chr15:64982066 | -12,416 | -5,696 | -4,864 | — |
| chr15_64981940_A_G | chr15:64981940 | -12,352 | -3,232 | -2,688 | — |
| chr15_64982028_A_G | chr15:64982028 | -12,352 | -3,744 | -3,840 | — |
| chr15_64982049_T_G | chr15:64982049 | -12,352 | -5,824 | -6,400 | — |
| chr15_64982070_A_G | chr15:64982070 | 12,352 | 5,088 | 5,376 | — |
| chr15_64982005_A_T | chr15:64982005 | -12,320 | -3,968 | -5,376 | — |
| chr15_64982053_A_C | chr15:64982053 | -12,320 | -5,600 | -4,864 | — |
| chr15_64982041_A_C | chr15:64982041 | 12,256 | 4,512 | 6,528 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.