Home / Gene
SULT2A1
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of SULT2A1, reducing the inducible sulfonation capacity for hydroxysteroids and clinical substrates such as budesonide.
Affected substrate drugs (PharmGKB): DHEA; budesonide
Scored variants near SULT2A1
chr19:47,770,466..47,986,315, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr19_47778453_C_A | chr19:47778453 | -27,808 | -18,160 | -175,872 | — |
| chr19_47778453_C_G | chr19:47778453 | -27,488 | -18,128 | -174,592 | — |
| chr19_47778454_C_G | chr19:47778454 | -26,592 | -15,952 | -179,968 | — |
| chr19_47778454_C_A | chr19:47778454 | -22,912 | -14,576 | -162,048 | — |
| chr19_47778446_G_A | chr19:47778446 | -20,736 | -9,792 | -97,792 | — |
| chr19_47778452_A_G | chr19:47778452 | -17,728 | -11,584 | -105,984 | — |
| chr19_47778450_G_T | chr19:47778450 | -13,984 | -10,240 | -98,560 | — |
| chr19_47778452_A_C | chr19:47778452 | -13,600 | -10,912 | -87,552 | — |
| chr19_47778446_G_T | chr19:47778446 | -12,992 | -7,712 | -68,352 | — |
| chr19_47778455_A_T | chr19:47778455 | -11,968 | -12,928 | -110,592 | — |
| chr19_47778386_C_G | chr19:47778386 | 11,328 | 1,888 | 1,024 | — |
| chr19_47778455_A_C | chr19:47778455 | -10,784 | -13,056 | -102,400 | — |
| chr19_47778402_C_G | chr19:47778402 | -10,048 | -2,624 | -17,920 | — |
| chr19_47778386_C_A | chr19:47778386 | 9,920 | 1,888 | -7,168 | — |
| chr19_47778402_C_A | chr19:47778402 | -9,664 | -1,728 | -14,336 | — |
| chr19_47778385_A_T | chr19:47778385 | 9,280 | 1,824 | -1,280 | — |
| chr19_47778385_A_G | chr19:47778385 | 9,248 | 2,464 | 0 | — |
| chr19_47778383_C_T | chr19:47778383 | 8,960 | 2,624 | 5,632 | — |
| chr19_47778428_T_G | chr19:47778428 | 8,928 | 4,064 | 21,504 | — |
| chr19_47778384_C_T | chr19:47778384 | 8,672 | 3,360 | 3,840 | — |
| chr19_47778384_C_A | chr19:47778384 | 7,872 | 3,040 | 5,120 | — |
| chr19_47778446_G_C | chr19:47778446 | -7,488 | -6,368 | -47,616 | — |
| chr19_47778451_T_G | chr19:47778451 | 7,040 | -4,160 | -13,312 | — |
| chr19_47778381_G_C | chr19:47778381 | 6,976 | 2,464 | 3,072 | — |
| chr19_47778433_C_A | chr19:47778433 | 6,976 | 288 | 2,560 | — |
| chr19_47778386_C_T | chr19:47778386 | 6,912 | 416 | -1,536 | — |
| chr19_47778402_C_T | chr19:47778402 | -6,848 | -1,920 | -16,128 | — |
| chr19_47778432_T_G | chr19:47778432 | 6,848 | 1,312 | 9,984 | — |
| chr19_47778382_A_G | chr19:47778382 | 6,560 | 2,976 | 10,240 | — |
| chr19_47778444_T_G | chr19:47778444 | -6,272 | -4,128 | -33,536 | — |
| chr19_47778401_C_A | chr19:47778401 | -6,112 | -1,888 | -9,728 | — |
| chr19_47778448_C_G | chr19:47778448 | -6,080 | -6,208 | -39,936 | — |
| chr19_47778401_C_T | chr19:47778401 | -5,952 | -2,176 | -10,240 | — |
| chr19_47778401_C_G | chr19:47778401 | -5,824 | -2,176 | -10,496 | — |
| chr19_47778467_G_A | chr19:47778467 | 5,792 | 160 | 3,072 | — |
| chr19_47778467_G_C | chr19:47778467 | 5,792 | -448 | 3,584 | — |
| chr19_47778468_G_A | chr19:47778468 | 5,760 | -64 | 1,024 | — |
| chr19_47778466_G_C | chr19:47778466 | 5,696 | -512 | 5,632 | — |
| chr19_47778466_G_A | chr19:47778466 | 5,664 | 352 | 7,680 | — |
| chr19_47778468_G_T | chr19:47778468 | 5,600 | 2,496 | 11,264 | — |
| chr19_47778383_C_G | chr19:47778383 | 5,408 | 2,720 | 3,072 | — |
| chr19_47778383_C_A | chr19:47778383 | 5,376 | 2,496 | 256 | — |
| chr19_47778429_A_C | chr19:47778429 | -5,344 | 320 | -4,864 | — |
| chr19_47778467_G_T | chr19:47778467 | 5,280 | -128 | 5,120 | — |
| chr19_47778428_T_A | chr19:47778428 | 5,216 | 640 | 4,608 | — |
| chr19_47778432_T_C | chr19:47778432 | 5,056 | 800 | 4,608 | — |
| chr19_47778454_C_T | chr19:47778454 | -5,024 | -9,376 | -82,432 | — |
| chr19_47778382_A_T | chr19:47778382 | 4,992 | 2,912 | 8,960 | — |
| chr19_47778464_G_T | chr19:47778464 | 4,992 | -736 | -1,280 | — |
| chr19_47778509_G_T | chr19:47778509 | 4,960 | 1,696 | -2,048 | — |
| chr19_47778432_T_A | chr19:47778432 | 4,928 | 544 | 2,816 | — |
| chr19_47778400_T_G | chr19:47778400 | -4,864 | -2,144 | -14,080 | — |
| chr19_47778436_C_A | chr19:47778436 | -4,800 | -1,504 | -14,080 | — |
| chr19_47778428_T_C | chr19:47778428 | 4,800 | 640 | 7,936 | — |
| chr19_47778451_T_C | chr19:47778451 | 4,768 | -2,912 | -5,632 | — |
| chr19_47778537_C_T | chr19:47778537 | 4,736 | 288 | -5,120 | — |
| chr19_47778433_C_G | chr19:47778433 | 4,704 | 576 | 6,144 | — |
| chr19_47778468_G_C | chr19:47778468 | 4,704 | 768 | 6,144 | — |
| chr19_47778381_G_A | chr19:47778381 | 4,672 | 1,856 | 1,280 | — |
| chr19_47778434_A_C | chr19:47778434 | 4,640 | 1,408 | 6,656 | — |
| chr19_47778457_T_G | chr19:47778457 | 4,640 | -1,664 | -2,560 | — |
| chr19_47778457_T_A | chr19:47778457 | 4,576 | -1,120 | -2,560 | — |
| chr19_47778380_A_T | chr19:47778380 | 4,544 | 1,952 | 5,888 | — |
| chr19_47778455_A_G | chr19:47778455 | -4,512 | -11,888 | -83,712 | — |
| chr19_47778399_T_C | chr19:47778399 | -4,416 | -1,248 | -8,448 | — |
| chr19_47778456_T_G | chr19:47778456 | 4,384 | -5,184 | -27,904 | — |
| chr19_47778381_G_T | chr19:47778381 | 4,384 | 2,112 | 1,536 | — |
| chr19_47778451_T_A | chr19:47778451 | 4,352 | -1,888 | -4,608 | — |
| chr19_47778465_G_C | chr19:47778465 | 4,288 | 320 | 7,680 | — |
| chr19_47778400_T_A | chr19:47778400 | -4,224 | -2,112 | -15,616 | — |
| chr19_47778541_A_T | chr19:47778541 | -4,224 | 384 | -10,240 | — |
| chr19_47778465_G_T | chr19:47778465 | 4,224 | 512 | 8,704 | — |
| chr19_47778399_T_G | chr19:47778399 | -4,160 | -1,632 | -6,656 | — |
| chr19_47778449_C_G | chr19:47778449 | 4,128 | -3,488 | -10,240 | — |
| chr19_47778477_A_G | chr19:47778477 | -4,064 | 0 | -12,288 | — |
| chr19_47778403_G_A | chr19:47778403 | -4,032 | -1,728 | -10,240 | — |
| chr19_47778398_A_C | chr19:47778398 | 4,032 | 3,552 | 9,984 | — |
| chr19_47778436_C_T | chr19:47778436 | -4,000 | -1,152 | -11,264 | — |
| chr19_47778403_G_T | chr19:47778403 | -3,968 | -2,240 | -14,336 | — |
| chr19_47778403_G_C | chr19:47778403 | -3,904 | -2,560 | -11,776 | — |
| chr19_47778400_T_C | chr19:47778400 | -3,776 | -2,112 | -11,776 | — |
| chr19_47778465_G_A | chr19:47778465 | 3,712 | 416 | 6,656 | — |
| chr19_47778431_A_G | chr19:47778431 | 3,648 | -64 | 6,912 | — |
| chr19_47778452_A_T | chr19:47778452 | -3,584 | -7,968 | -52,736 | — |
| chr19_47778416_A_G | chr19:47778416 | -3,520 | -1,984 | -11,520 | — |
| chr19_47778419_G_T | chr19:47778419 | -3,424 | 576 | -8,448 | — |
| chr19_47778429_A_G | chr19:47778429 | 3,424 | 992 | 6,400 | — |
| chr19_47778445_G_A | chr19:47778445 | 3,392 | -2,592 | -12,800 | — |
| chr19_47778482_A_G | chr19:47778482 | -3,328 | -1,280 | -9,472 | — |
| chr19_47778427_G_A | chr19:47778427 | -3,328 | -1,248 | -5,632 | — |
| chr19_47778450_G_C | chr19:47778450 | -3,296 | -6,080 | -40,704 | — |
| chr19_47778480_G_T | chr19:47778480 | 3,296 | 2,880 | 11,520 | — |
| chr19_47778424_G_T | chr19:47778424 | 3,264 | 960 | 5,632 | — |
| chr19_47778292_C_G | chr19:47778292 | 3,136 | 576 | 6,912 | — |
| chr19_47778549_A_G | chr19:47778549 | 3,136 | -288 | -5,888 | — |
| chr19_47778296_G_C | chr19:47778296 | 3,104 | -960 | -10,496 | — |
| chr19_47778430_A_G | chr19:47778430 | 3,104 | 704 | 5,376 | — |
| chr19_47778436_C_G | chr19:47778436 | -3,040 | -672 | -8,448 | — |
| chr19_47778384_C_G | chr19:47778384 | 2,880 | 1,888 | 5,888 | — |
| chr19_47778379_A_C | chr19:47778379 | 2,880 | 1,120 | 4,352 | — |
| chr19_47778404_G_C | chr19:47778404 | -2,688 | -1,024 | -4,352 | — |
| chr19_47778397_G_C | chr19:47778397 | -2,624 | -800 | -4,864 | — |
| chr19_47778414_G_T | chr19:47778414 | -2,528 | 96 | -7,424 | — |
| chr19_47778480_G_A | chr19:47778480 | 2,496 | 1,440 | 5,376 | — |
| chr19_47778293_C_G | chr19:47778293 | 2,496 | 416 | 4,352 | — |
| chr19_47778423_A_T | chr19:47778423 | 2,336 | 1,280 | 6,656 | — |
| chr19_47778456_T_A | chr19:47778456 | 2,208 | -928 | -5,120 | — |
| chr19_47778412_T_C | chr19:47778412 | 2,176 | 608 | 4,352 | — |
| chr19_47778406_T_A | chr19:47778406 | -2,112 | -416 | -10,752 | — |
| chr19_47778447_G_C | chr19:47778447 | 2,080 | -1,376 | -6,144 | — |
| chr19_47778441_C_A | chr19:47778441 | -2,048 | 256 | 4,608 | — |
| chr19_47778294_T_C | chr19:47778294 | -1,984 | -1,248 | -12,032 | — |
| chr19_47778411_C_G | chr19:47778411 | -1,984 | -992 | -6,656 | — |
| chr19_47778449_C_A | chr19:47778449 | 1,952 | -1,760 | -5,632 | — |
| chr19_47778368_C_G | chr19:47778368 | 1,952 | 0 | -4,352 | — |
| chr19_47778463_C_G | chr19:47778463 | -1,792 | 672 | -6,144 | — |
| chr19_47778493_G_C | chr19:47778493 | 1,760 | 896 | 6,912 | — |
| chr19_47778457_T_C | chr19:47778457 | 1,728 | -1,376 | -5,120 | — |
| chr19_47778405_G_C | chr19:47778405 | -1,664 | -800 | -8,448 | — |
| chr19_47778476_G_A | chr19:47778476 | 1,600 | 1,504 | 8,960 | — |
| chr19_47778398_A_T | chr19:47778398 | 1,600 | 2,016 | 6,144 | — |
| chr19_47778413_G_C | chr19:47778413 | 1,600 | 768 | 5,888 | — |
| chr19_47778399_T_A | chr19:47778399 | -1,600 | -1,088 | -5,120 | — |
| chr19_47778480_G_C | chr19:47778480 | 1,568 | 1,280 | 7,936 | — |
| chr19_47778385_A_C | chr19:47778385 | -1,568 | 64 | -7,168 | — |
| chr19_47778407_C_A | chr19:47778407 | -1,536 | 128 | -6,400 | — |
| chr19_47778426_C_A | chr19:47778426 | -1,472 | -896 | -5,888 | — |
| chr19_47778526_C_G | chr19:47778526 | 1,472 | 928 | 4,864 | — |
| chr19_47778487_C_G | chr19:47778487 | 1,312 | -704 | -6,400 | — |
| chr19_47778470_A_T | chr19:47778470 | -1,312 | -864 | -5,120 | — |
| chr19_47778420_G_C | chr19:47778420 | -1,312 | -352 | -4,608 | — |
| chr19_47778369_A_C | chr19:47778369 | -1,280 | -960 | -9,728 | — |
| chr19_47778406_T_G | chr19:47778406 | -1,280 | -448 | -6,400 | — |
| chr19_47778316_G_T | chr19:47778316 | 1,280 | -352 | -4,864 | — |
| chr19_47778503_G_T | chr19:47778503 | -1,248 | 352 | 4,864 | — |
| chr19_47778494_C_G | chr19:47778494 | 1,248 | 544 | -4,608 | — |
| chr19_47778419_G_A | chr19:47778419 | -1,216 | -96 | -8,960 | — |
| chr19_47778445_G_C | chr19:47778445 | 1,184 | -3,904 | -20,992 | — |
| chr19_47778438_C_G | chr19:47778438 | 1,184 | -896 | -5,376 | — |
| chr19_47778286_T_C | chr19:47778286 | -1,152 | -1,920 | -12,288 | — |
| chr19_47778490_A_G | chr19:47778490 | -1,120 | -96 | -10,240 | — |
| chr19_47778447_G_T | chr19:47778447 | 1,120 | -2,016 | -9,728 | — |
| chr19_47778445_G_T | chr19:47778445 | 1,088 | -2,688 | -13,824 | — |
| chr19_47778448_C_T | chr19:47778448 | -1,056 | -2,848 | -14,848 | — |
| chr19_47778497_C_G | chr19:47778497 | 1,056 | 576 | 4,608 | — |
| chr19_47778318_G_T | chr19:47778318 | 992 | -256 | -5,376 | — |
| chr19_47778345_C_T | chr19:47778345 | -992 | -224 | -4,608 | — |
| chr19_47778406_T_C | chr19:47778406 | -960 | 64 | -6,400 | — |
| chr19_47778450_G_A | chr19:47778450 | 928 | -2,336 | -10,240 | — |
| chr19_47778462_C_G | chr19:47778462 | -928 | -1,280 | -8,704 | — |
| chr19_47778483_C_T | chr19:47778483 | -896 | -1,792 | -11,264 | — |
| chr19_47778416_A_C | chr19:47778416 | 864 | 256 | 6,400 | — |
| chr19_47778516_T_A | chr19:47778516 | -864 | -1,536 | -5,888 | — |
| chr19_47778350_C_G | chr19:47778350 | -864 | -512 | -4,864 | — |
| chr19_47778438_C_A | chr19:47778438 | 832 | -1,568 | -8,704 | — |
| chr19_47778357_G_C | chr19:47778357 | -832 | -768 | -4,608 | — |
| chr19_47778368_C_A | chr19:47778368 | 800 | 32 | -4,864 | — |
| chr19_47778371_G_T | chr19:47778371 | -800 | -480 | -4,352 | — |
| chr19_47778408_C_A | chr19:47778408 | 768 | 1,216 | 4,608 | — |
| chr19_47778290_C_G | chr19:47778290 | 736 | 320 | 6,400 | — |
| chr19_47778390_T_G | chr19:47778390 | -736 | -672 | -4,352 | — |
| chr19_47778435_C_A | chr19:47778435 | -704 | -1,152 | -6,144 | — |
| chr19_47778345_C_A | chr19:47778345 | 704 | -160 | -4,608 | — |
| chr19_47778475_G_C | chr19:47778475 | -704 | 1,216 | 4,608 | — |
| chr19_47778288_G_C | chr19:47778288 | -672 | -288 | -9,216 | — |
| chr19_47778453_C_T | chr19:47778453 | -640 | -11,104 | -77,568 | — |
| chr19_47778476_G_C | chr19:47778476 | 576 | 1,376 | 5,888 | — |
| chr19_47778444_T_A | chr19:47778444 | 544 | -1,568 | -10,752 | — |
| chr19_47778472_C_G | chr19:47778472 | -544 | -192 | -5,888 | — |
| chr19_47778542_G_C | chr19:47778542 | 512 | 800 | 6,912 | — |
| chr19_47778484_G_A | chr19:47778484 | 512 | 1,440 | 6,144 | — |
| chr19_47778318_G_A | chr19:47778318 | 512 | -416 | -5,376 | — |
| chr19_47778473_T_G | chr19:47778473 | -416 | -288 | -4,608 | — |
| chr19_47778405_G_A | chr19:47778405 | 384 | -448 | -8,448 | — |
| chr19_47778426_C_T | chr19:47778426 | 384 | -544 | -4,352 | — |
| chr19_47778352_G_C | chr19:47778352 | -352 | -1,376 | -11,008 | — |
| chr19_47778435_C_T | chr19:47778435 | -320 | -1,984 | -9,472 | — |
| chr19_47778477_A_T | chr19:47778477 | 320 | -1,280 | -4,864 | — |
| chr19_47778291_C_G | chr19:47778291 | -320 | -64 | 4,608 | — |
| chr19_47778543_G_T | chr19:47778543 | -320 | 1,024 | 4,608 | — |
| chr19_47778543_G_C | chr19:47778543 | -288 | 448 | 4,864 | — |
| chr19_47778483_C_G | chr19:47778483 | 288 | -544 | -4,608 | — |
| chr19_47778311_G_A | chr19:47778311 | -256 | -512 | -4,608 | — |
| chr19_47778548_G_C | chr19:47778548 | 224 | 1,024 | 4,608 | — |
| chr19_47778354_G_C | chr19:47778354 | -192 | -1,152 | -10,752 | — |
| chr19_47778435_C_G | chr19:47778435 | 192 | -1,728 | -6,656 | — |
| chr19_47778478_G_C | chr19:47778478 | 192 | 960 | 5,888 | — |
| chr19_47778296_G_T | chr19:47778296 | 192 | -128 | -4,608 | — |
| chr19_47778449_C_T | chr19:47778449 | 192 | -1,152 | -4,608 | — |
| chr19_47778323_A_G | chr19:47778323 | 192 | 0 | 4,352 | — |
| chr19_47778544_A_C | chr19:47778544 | 160 | 512 | 5,120 | — |
| chr19_47778478_G_A | chr19:47778478 | -160 | 864 | 4,864 | — |
| chr19_47778471_C_G | chr19:47778471 | 160 | 64 | -4,608 | — |
| chr19_47778405_G_T | chr19:47778405 | 128 | 128 | -6,400 | — |
| chr19_47778321_T_G | chr19:47778321 | -128 | 32 | 4,608 | — |
| chr19_47778481_G_C | chr19:47778481 | 96 | 544 | 7,680 | — |
| chr19_47778319_A_G | chr19:47778319 | -96 | 352 | 5,376 | — |
| chr19_47778407_C_G | chr19:47778407 | 64 | 448 | -5,120 | — |
| chr19_47778543_G_A | chr19:47778543 | 64 | 704 | 5,120 | — |
| chr19_47778346_C_T | chr19:47778346 | 64 | -256 | -4,608 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.