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UGT1A4
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated induction of UGT1A4, leading to attenuated clearance and increased systemic exposure of its clinical substrates such as lamotrigine.
Affected substrate drugs (PharmGKB): lamotrigine; tamoxifen; ABT-751; anastrozole; testosterone
Scored variants near UGT1A4
chr2:233,618,735..233,873,300, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr2_233718647_A_T | chr2:233718647 | 51,392 | 14,208 | 24,832 | — |
| chr2_233718667_T_G | chr2:233718667 | -50,048 | -17,024 | -36,352 | — |
| chr2_233691696_G_T | chr2:233691696 | 48,384 | 9,024 | 46,400 | — |
| chr2_233718674_T_G | chr2:233718674 | -47,744 | -17,168 | -35,200 | — |
| chr2_233718675_A_T | chr2:233718675 | -45,760 | -14,432 | -36,736 | — |
| chr2_233718658_G_C | chr2:233718658 | -45,056 | -15,328 | -34,560 | — |
| chr2_233718677_T_G | chr2:233718677 | -44,992 | -16,128 | -41,216 | — |
| chr2_233718674_T_C | chr2:233718674 | -43,456 | -14,128 | -28,800 | — |
| chr2_233718681_T_A | chr2:233718681 | -42,176 | -14,192 | -35,328 | — |
| chr2_233718675_A_C | chr2:233718675 | -42,112 | -12,656 | -31,232 | — |
| chr2_233718621_T_G | chr2:233718621 | -41,280 | -12,736 | -27,008 | — |
| chr2_233718557_G_C | chr2:233718557 | 40,576 | 12,288 | 17,792 | — |
| chr2_233718666_T_A | chr2:233718666 | -40,128 | -14,960 | -27,520 | — |
| chr2_233718681_T_G | chr2:233718681 | -40,064 | -12,848 | -29,568 | — |
| chr2_233718665_A_C | chr2:233718665 | -39,872 | -12,400 | -25,856 | — |
| chr2_233718659_T_C | chr2:233718659 | -39,360 | -12,512 | -31,232 | — |
| chr2_233718682_A_C | chr2:233718682 | -39,104 | -13,408 | -31,232 | — |
| chr2_233718670_T_G | chr2:233718670 | -37,120 | -12,096 | -23,552 | — |
| chr2_233718659_T_G | chr2:233718659 | -37,056 | -12,048 | -29,056 | — |
| chr2_233718647_A_G | chr2:233718647 | 36,032 | 9,696 | 17,664 | — |
| chr2_233718674_T_A | chr2:233718674 | -35,648 | -11,792 | -24,320 | — |
| chr2_233718662_T_A | chr2:233718662 | 35,584 | 13,504 | 16,768 | — |
| chr2_233718644_C_G | chr2:233718644 | 35,008 | 8,576 | 21,248 | — |
| chr2_233718677_T_A | chr2:233718677 | -34,880 | -12,576 | -30,080 | — |
| chr2_233718649_C_A | chr2:233718649 | -34,752 | -9,632 | -26,496 | — |
| chr2_233718667_T_A | chr2:233718667 | -34,240 | -11,984 | -20,864 | — |
| chr2_233718683_A_T | chr2:233718683 | -34,240 | -11,488 | -29,056 | — |
| chr2_233691675_A_C | chr2:233691675 | 34,144 | 9,376 | 27,520 | — |
| chr2_233718681_T_C | chr2:233718681 | -34,048 | -12,096 | -28,544 | — |
| chr2_233718675_A_G | chr2:233718675 | -33,920 | -11,408 | -24,576 | — |
| chr2_233718663_A_T | chr2:233718663 | 33,280 | 6,752 | 17,152 | — |
| chr2_233718710_T_G | chr2:233718710 | 31,936 | 10,048 | 20,480 | — |
| chr2_233718672_G_C | chr2:233718672 | -31,168 | -10,976 | -20,736 | — |
| chr2_233718649_C_G | chr2:233718649 | -30,976 | -9,584 | -22,144 | — |
| chr2_233718601_G_A | chr2:233718601 | 30,848 | 9,728 | 12,928 | — |
| chr2_233718682_A_G | chr2:233718682 | -30,592 | -10,592 | -23,552 | — |
| chr2_233718704_T_C | chr2:233718704 | 30,464 | 10,144 | 16,384 | — |
| chr2_233718703_C_G | chr2:233718703 | 29,568 | 7,904 | 16,512 | — |
| chr2_233718555_G_C | chr2:233718555 | 29,056 | 9,504 | 13,824 | — |
| chr2_233718625_T_A | chr2:233718625 | 29,056 | 8,896 | 14,848 | — |
| chr2_233718659_T_A | chr2:233718659 | -28,800 | -9,904 | -22,528 | — |
| chr2_233718658_G_A | chr2:233718658 | -28,480 | -9,488 | -18,176 | — |
| chr2_233718677_T_C | chr2:233718677 | -28,096 | -9,488 | -21,632 | — |
| chr2_233718683_A_C | chr2:233718683 | -27,904 | -9,808 | -22,912 | — |
| chr2_233718682_A_T | chr2:233718682 | -27,264 | -9,088 | -20,736 | — |
| chr2_233718575_C_T | chr2:233718575 | 27,136 | 6,720 | 9,600 | — |
| chr2_233718665_A_G | chr2:233718665 | -27,136 | -8,672 | -16,384 | — |
| chr2_233718684_C_T | chr2:233718684 | -26,816 | -10,096 | -25,984 | — |
| chr2_233718710_T_C | chr2:233718710 | 26,560 | 8,288 | 16,896 | — |
| chr2_233718676_A_G | chr2:233718676 | -26,304 | -9,760 | -25,600 | — |
| chr2_233718696_A_T | chr2:233718696 | -26,304 | -8,400 | -18,176 | — |
| chr2_233718666_T_C | chr2:233718666 | -26,240 | -9,632 | -16,512 | — |
| chr2_233718658_G_T | chr2:233718658 | -26,112 | -8,864 | -17,152 | — |
| chr2_233718663_A_C | chr2:233718663 | 25,984 | 4,736 | 15,744 | — |
| chr2_233718668_A_T | chr2:233718668 | -25,152 | -7,712 | -17,536 | — |
| chr2_233718676_A_C | chr2:233718676 | -24,512 | -8,080 | -21,504 | — |
| chr2_233718602_C_G | chr2:233718602 | 24,192 | 7,584 | 10,112 | — |
| chr2_233718666_T_G | chr2:233718666 | -24,128 | -8,832 | -14,848 | — |
| chr2_233691757_C_A | chr2:233691757 | 23,904 | 4,000 | 20,096 | — |
| chr2_233718691_A_G | chr2:233718691 | -23,744 | -7,792 | -15,232 | — |
| chr2_233718684_C_A | chr2:233718684 | -23,552 | -9,040 | -23,040 | — |
| chr2_233718709_A_G | chr2:233718709 | 23,168 | 8,416 | 14,976 | — |
| chr2_233718671_G_A | chr2:233718671 | 22,912 | 5,792 | 8,448 | — |
| chr2_233718544_A_T | chr2:233718544 | 22,656 | 6,624 | 10,112 | — |
| chr2_233718621_T_A | chr2:233718621 | -22,528 | -6,720 | -14,720 | — |
| chr2_233718678_A_T | chr2:233718678 | -22,208 | -8,224 | -19,200 | — |
| chr2_233718694_G_C | chr2:233718694 | -22,208 | -7,136 | -13,696 | — |
| chr2_233718707_C_T | chr2:233718707 | -22,208 | -7,536 | -15,360 | — |
| chr2_233718683_A_G | chr2:233718683 | -22,144 | -7,344 | -16,896 | — |
| chr2_233718575_C_G | chr2:233718575 | 22,016 | 3,904 | 7,808 | — |
| chr2_233718710_T_A | chr2:233718710 | 21,952 | 5,440 | 15,232 | — |
| chr2_233718594_C_A | chr2:233718594 | -21,888 | -7,136 | -13,312 | — |
| chr2_233718591_G_T | chr2:233718591 | -21,824 | -6,880 | -13,056 | — |
| chr2_233718619_G_A | chr2:233718619 | -21,696 | -6,576 | -12,800 | — |
| chr2_233718605_T_A | chr2:233718605 | 21,632 | 4,576 | 8,064 | — |
| chr2_233718705_T_G | chr2:233718705 | 21,632 | 5,472 | 11,136 | — |
| chr2_233718638_T_G | chr2:233718638 | -21,376 | -5,952 | -13,696 | — |
| chr2_233718673_G_T | chr2:233718673 | 21,376 | 3,264 | 6,016 | — |
| chr2_233718601_G_C | chr2:233718601 | 20,992 | 8,352 | 12,544 | — |
| chr2_233718650_G_C | chr2:233718650 | 20,928 | 6,976 | 9,600 | — |
| chr2_233718667_T_C | chr2:233718667 | -20,928 | -9,248 | -13,184 | — |
| chr2_233718697_C_A | chr2:233718697 | -20,928 | -6,912 | -13,056 | — |
| chr2_233718696_A_C | chr2:233718696 | -20,864 | -6,336 | -13,696 | — |
| chr2_233718684_C_G | chr2:233718684 | -20,544 | -7,360 | -18,304 | — |
| chr2_233718693_G_T | chr2:233718693 | 20,544 | 7,520 | 10,752 | — |
| chr2_233718711_T_C | chr2:233718711 | 20,416 | 7,584 | 14,208 | — |
| chr2_233718593_T_G | chr2:233718593 | -20,160 | -7,136 | -12,160 | — |
| chr2_233718591_G_C | chr2:233718591 | -19,968 | -6,016 | -11,648 | — |
| chr2_233718649_C_T | chr2:233718649 | -19,648 | -6,240 | -14,848 | — |
| chr2_233718597_A_G | chr2:233718597 | 19,584 | 7,008 | 11,520 | — |
| chr2_233718670_T_A | chr2:233718670 | -19,520 | -5,696 | -11,648 | — |
| chr2_233718665_A_T | chr2:233718665 | -19,328 | -4,000 | -12,672 | — |
| chr2_233718643_C_A | chr2:233718643 | 19,264 | 4,416 | 8,320 | — |
| chr2_233718656_C_A | chr2:233718656 | -18,944 | -5,536 | -13,312 | — |
| chr2_233718672_G_A | chr2:233718672 | -18,688 | -6,528 | -12,032 | — |
| chr2_233718622_T_G | chr2:233718622 | -18,624 | -5,920 | -12,288 | — |
| chr2_233718695_C_G | chr2:233718695 | 18,624 | 7,136 | 12,544 | — |
| chr2_233718577_C_A | chr2:233718577 | -18,560 | -5,472 | -9,984 | — |
| chr2_233718646_T_A | chr2:233718646 | 18,432 | 5,760 | 11,392 | — |
| chr2_233718713_C_T | chr2:233718713 | -18,432 | -6,768 | -13,440 | — |
| chr2_233718595_A_T | chr2:233718595 | -18,240 | -6,208 | -12,928 | — |
| chr2_233718591_G_A | chr2:233718591 | -18,176 | -5,728 | -11,264 | — |
| chr2_233718661_A_C | chr2:233718661 | -17,984 | -5,792 | -12,800 | — |
| chr2_233718706_C_G | chr2:233718706 | 17,984 | 4,576 | 3,968 | — |
| chr2_233718569_A_C | chr2:233718569 | 17,792 | 5,056 | 8,576 | — |
| chr2_233718672_G_T | chr2:233718672 | -17,728 | -5,632 | -11,392 | — |
| chr2_233718645_A_G | chr2:233718645 | 17,664 | 4,768 | 10,624 | — |
| chr2_233718567_G_C | chr2:233718567 | -17,280 | -5,248 | -8,192 | — |
| chr2_233718593_T_A | chr2:233718593 | -17,280 | -6,144 | -11,136 | — |
| chr2_233718668_A_C | chr2:233718668 | -17,216 | -6,320 | -12,032 | — |
| chr2_233718545_T_A | chr2:233718545 | 17,152 | 5,984 | 9,728 | — |
| chr2_233718595_A_G | chr2:233718595 | -16,960 | -5,536 | -9,600 | — |
| chr2_233718696_A_G | chr2:233718696 | -16,960 | -5,824 | -11,520 | — |
| chr2_233718680_G_C | chr2:233718680 | -16,704 | -5,504 | -12,928 | — |
| chr2_233718686_G_A | chr2:233718686 | 16,576 | 4,768 | 9,088 | — |
| chr2_233718712_A_G | chr2:233718712 | 16,320 | 5,200 | 11,008 | — |
| chr2_233718711_T_G | chr2:233718711 | 16,256 | 4,512 | 10,752 | — |
| chr2_233718565_T_A | chr2:233718565 | -16,192 | -5,632 | -9,344 | — |
| chr2_233718579_G_T | chr2:233718579 | -16,192 | -5,216 | -9,472 | — |
| chr2_233718661_A_T | chr2:233718661 | -16,192 | -4,672 | -12,544 | — |
| chr2_233718655_G_T | chr2:233718655 | 16,000 | 5,568 | 7,552 | — |
| chr2_233718577_C_T | chr2:233718577 | -15,808 | -5,248 | -11,136 | — |
| chr2_233691687_C_G | chr2:233691687 | 15,776 | 5,088 | 14,464 | — |
| chr2_233718651_A_T | chr2:233718651 | -15,616 | -5,312 | -9,472 | — |
| chr2_233718669_A_G | chr2:233718669 | -15,616 | -7,264 | -8,960 | — |
| chr2_233718596_G_C | chr2:233718596 | 15,424 | 5,856 | 9,984 | — |
| chr2_233718574_C_G | chr2:233718574 | 15,360 | 4,512 | 6,528 | — |
| chr2_233718620_A_T | chr2:233718620 | 15,360 | 5,152 | 4,992 | — |
| chr2_233718637_T_A | chr2:233718637 | -15,360 | -4,960 | -9,856 | — |
| chr2_233718654_G_T | chr2:233718654 | -15,360 | -4,960 | -10,624 | — |
| chr2_233718605_T_C | chr2:233718605 | -15,296 | -4,960 | -8,320 | — |
| chr2_233718646_T_G | chr2:233718646 | 15,168 | 4,736 | 8,320 | — |
| chr2_233718685_T_G | chr2:233718685 | -15,104 | -5,440 | -8,448 | — |
| chr2_233718695_C_A | chr2:233718695 | 15,040 | 5,248 | 8,960 | — |
| chr2_233718567_G_A | chr2:233718567 | -14,592 | -4,576 | -8,448 | — |
| chr2_233718629_T_A | chr2:233718629 | -14,528 | -4,416 | -9,344 | — |
| chr2_233718643_C_T | chr2:233718643 | 14,528 | 4,096 | 5,632 | — |
| chr2_233718663_A_G | chr2:233718663 | -14,528 | -4,576 | -8,704 | — |
| chr2_233718547_A_T | chr2:233718547 | 14,336 | 4,896 | 8,064 | — |
| chr2_233718553_A_C | chr2:233718553 | 14,272 | 4,128 | 7,040 | — |
| chr2_233718641_G_C | chr2:233718641 | 14,144 | 4,000 | 6,272 | — |
| chr2_233718669_A_C | chr2:233718669 | -14,080 | -6,304 | -6,656 | — |
| chr2_233718673_G_C | chr2:233718673 | 14,016 | 2,976 | 6,016 | — |
| chr2_233718678_A_C | chr2:233718678 | 13,952 | 3,760 | 10,624 | — |
| chr2_233718623_G_C | chr2:233718623 | -13,824 | -3,360 | -9,472 | — |
| chr2_233718592_G_T | chr2:233718592 | -13,632 | -4,576 | -8,704 | — |
| chr2_233718697_C_T | chr2:233718697 | -13,568 | -4,960 | -8,064 | — |
| chr2_233718709_A_C | chr2:233718709 | 13,376 | 5,088 | 10,752 | — |
| chr2_233718611_A_G | chr2:233718611 | 12,992 | 4,736 | 10,496 | — |
| chr2_233718712_A_C | chr2:233718712 | 12,992 | 3,504 | 10,112 | — |
| chr2_233718671_G_C | chr2:233718671 | 12,800 | 3,392 | 6,656 | — |
| chr2_233718713_C_G | chr2:233718713 | -12,736 | -5,040 | -10,112 | — |
| chr2_233718594_C_G | chr2:233718594 | -12,672 | -4,512 | -7,936 | — |
| chr2_233718650_G_T | chr2:233718650 | -12,608 | -3,392 | -9,984 | — |
| chr2_233718679_A_C | chr2:233718679 | -12,544 | -3,712 | -7,808 | — |
| chr2_233718685_T_A | chr2:233718685 | -12,544 | -4,096 | -9,216 | — |
| chr2_233718563_A_T | chr2:233718563 | -12,288 | -3,808 | -7,552 | — |
| chr2_233718644_C_T | chr2:233718644 | -12,288 | -4,448 | -7,168 | — |
| chr2_233718630_C_G | chr2:233718630 | 12,224 | 2,688 | 7,296 | — |
| chr2_233718708_A_T | chr2:233718708 | 12,224 | 3,568 | 9,600 | — |
| chr2_233718691_A_T | chr2:233718691 | -12,160 | -4,448 | -7,936 | — |
| chr2_233718711_T_A | chr2:233718711 | 12,160 | 2,976 | 7,552 | — |
| chr2_233718573_T_G | chr2:233718573 | 12,032 | 3,616 | 6,272 | — |
| chr2_233718606_T_C | chr2:233718606 | 12,032 | 3,392 | 4,736 | — |
| chr2_233718699_T_A | chr2:233718699 | -12,032 | -4,352 | -8,192 | — |
| chr2_233718592_G_A | chr2:233718592 | -11,968 | -3,680 | -7,936 | — |
| chr2_233718577_C_G | chr2:233718577 | -11,904 | -3,232 | -4,608 | — |
| chr2_233718553_A_T | chr2:233718553 | 11,840 | 3,296 | 5,760 | — |
| chr2_233718594_C_T | chr2:233718594 | -11,840 | -4,416 | -7,552 | — |
| chr2_233718600_A_C | chr2:233718600 | -11,776 | -4,352 | -5,376 | — |
| chr2_233718639_G_T | chr2:233718639 | 11,776 | 2,304 | 4,096 | — |
| chr2_233718601_G_T | chr2:233718601 | 11,648 | 4,224 | 5,760 | — |
| chr2_233718629_T_C | chr2:233718629 | -11,584 | -3,520 | -6,784 | — |
| chr2_233718631_C_G | chr2:233718631 | -11,584 | -3,552 | -7,296 | — |
| chr2_233718618_T_A | chr2:233718618 | -11,456 | -3,520 | -6,912 | — |
| chr2_233718687_G_A | chr2:233718687 | -11,200 | -3,488 | -5,376 | — |
| chr2_233718608_A_G | chr2:233718608 | 11,008 | 2,624 | 6,656 | — |
| chr2_233718653_A_C | chr2:233718653 | 11,008 | 2,688 | 6,144 | — |
| chr2_233718662_T_C | chr2:233718662 | 11,008 | 5,056 | 6,400 | — |
| chr2_233718679_A_G | chr2:233718679 | -11,008 | -2,928 | -6,016 | — |
| chr2_233718626_C_T | chr2:233718626 | 10,944 | 3,872 | 5,248 | — |
| chr2_233718566_T_A | chr2:233718566 | -10,880 | -3,680 | -6,912 | — |
| chr2_233718588_C_G | chr2:233718588 | -10,688 | -3,936 | -7,040 | — |
| chr2_233718616_C_T | chr2:233718616 | -10,688 | -3,616 | -8,704 | — |
| chr2_233718590_G_A | chr2:233718590 | 10,624 | 2,912 | 5,248 | — |
| chr2_233718595_A_C | chr2:233718595 | -10,624 | -3,520 | -4,096 | — |
| chr2_233718597_A_C | chr2:233718597 | 10,624 | 3,424 | 6,016 | — |
| chr2_233718680_G_A | chr2:233718680 | -10,624 | -4,208 | -9,472 | — |
| chr2_233718599_G_A | chr2:233718599 | 10,496 | 2,400 | 3,584 | — |
| chr2_233718679_A_T | chr2:233718679 | -10,496 | -2,464 | -6,272 | — |
| chr2_233718631_C_T | chr2:233718631 | -10,368 | -3,072 | -7,424 | — |
| chr2_233718618_T_C | chr2:233718618 | -10,304 | -3,840 | -4,480 | — |
| chr2_233718702_T_G | chr2:233718702 | 10,304 | 3,616 | 6,016 | — |
| chr2_233718633_A_C | chr2:233718633 | 10,240 | 4,320 | 5,632 | — |
| chr2_233718680_G_T | chr2:233718680 | 10,240 | 1,792 | 6,144 | — |
| chr2_233691648_T_A | chr2:233691648 | -9,408 | -3,680 | -11,456 | — |
| chr2_233691723_C_G | chr2:233691723 | -8,448 | -3,040 | -10,816 | — |
| chr2_233691664_G_T | chr2:233691664 | -8,256 | -2,656 | -10,304 | — |
| chr2_233691696_G_C | chr2:233691696 | 6,912 | 1,760 | 10,624 | — |
| chr2_233691682_T_G | chr2:233691682 | 4,032 | 1,728 | 10,688 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.