Home / Gene
UGT2B7
receptor: PXRTier 1
CAMIP causal chains
PXR
Blunted receptor-mediated modulation of UGT2B7, altering the adaptive clearance rate of heavily utilized opioid and immunosuppressant substrates.
Affected substrate drugs (PharmGKB): lamotrigine; valproic acid; morphine; oxcarbazepine; fentanyl; zidovudine
Scored variants near UGT2B7
chr4:68,951,263..69,212,987, gene body plus 100 kb. Showing the strongest 200 by effect size.
| Variant | Position | PXR ▾ | FXR | AhR | AF |
|---|---|---|---|---|---|
| chr4_69020518_C_A | chr4:69020518 | -51,232 | -22,912 | -24,000 | — |
| chr4_69020518_C_G | chr4:69020518 | -46,400 | -20,832 | -21,056 | — |
| chr4_69020536_T_A | chr4:69020536 | -45,792 | -18,240 | -21,856 | 1.3e-5 |
| chr4_69020540_T_A | chr4:69020540 | -44,192 | -17,536 | -18,368 | — |
| chr4_69020536_T_G | chr4:69020536 | -43,232 | -17,600 | -19,776 | — |
| chr4_69020540_T_C | chr4:69020540 | -42,656 | -17,248 | -17,216 | — |
| chr4_69020534_C_T | chr4:69020534 | -42,176 | -17,760 | -18,496 | — |
| chr4_69020518_C_T | chr4:69020518 | -41,952 | -18,880 | -19,584 | — |
| chr4_69020534_C_G | chr4:69020534 | -40,896 | -17,056 | -16,992 | — |
| chr4_69020541_A_T | chr4:69020541 | -39,840 | -15,488 | -17,120 | — |
| chr4_69020541_A_C | chr4:69020541 | -39,328 | -15,392 | -16,192 | — |
| chr4_69020537_A_T | chr4:69020537 | -38,016 | -13,920 | -17,888 | — |
| chr4_69020538_T_A | chr4:69020538 | -37,728 | -14,528 | -14,304 | — |
| chr4_69020520_A_C | chr4:69020520 | -37,152 | -16,512 | -17,152 | — |
| chr4_69020528_T_G | chr4:69020528 | -37,152 | -16,960 | -18,208 | — |
| chr4_69020525_C_A | chr4:69020525 | -36,768 | -16,000 | -16,864 | — |
| chr4_69020528_T_C | chr4:69020528 | -36,480 | -16,768 | -17,536 | — |
| chr4_69020578_T_G | chr4:69020578 | 36,256 | 9,216 | 8,224 | — |
| chr4_69020529_T_A | chr4:69020529 | -36,096 | -15,808 | -18,208 | — |
| chr4_69020520_A_T | chr4:69020520 | -35,616 | -15,744 | -16,576 | — |
| chr4_69020528_T_A | chr4:69020528 | -35,072 | -15,552 | -17,280 | — |
| chr4_69020492_T_A | chr4:69020492 | 34,464 | 11,616 | 13,088 | — |
| chr4_69020530_A_C | chr4:69020530 | -33,472 | -14,624 | -15,424 | — |
| chr4_69020525_C_G | chr4:69020525 | -33,088 | -14,528 | -14,560 | — |
| chr4_69020522_G_T | chr4:69020522 | -32,320 | -13,664 | -12,896 | — |
| chr4_69020522_G_A | chr4:69020522 | -32,064 | -13,568 | -12,736 | 2.0e-5 |
| chr4_69020537_A_C | chr4:69020537 | -31,904 | -12,704 | -14,432 | — |
| chr4_69020494_C_T | chr4:69020494 | -31,616 | -15,520 | -13,024 | — |
| chr4_69020538_T_C | chr4:69020538 | -31,168 | -12,800 | -10,880 | — |
| chr4_69020492_T_C | chr4:69020492 | 31,072 | 10,304 | 12,640 | — |
| chr4_69020542_C_A | chr4:69020542 | -30,528 | -11,136 | -10,752 | — |
| chr4_69020536_T_C | chr4:69020536 | -28,576 | -11,360 | -11,328 | — |
| chr4_69020538_T_G | chr4:69020538 | -27,808 | -11,136 | -9,376 | — |
| chr4_69020525_C_T | chr4:69020525 | -27,392 | -11,904 | -11,680 | 1.5e-1 |
| chr4_69020542_C_G | chr4:69020542 | -27,392 | -11,360 | -10,336 | — |
| chr4_69020522_G_C | chr4:69020522 | -27,296 | -12,192 | -11,040 | — |
| chr4_69020491_A_G | chr4:69020491 | 27,104 | 10,816 | 12,832 | — |
| chr4_69020492_T_G | chr4:69020492 | 26,976 | 7,616 | 8,704 | — |
| chr4_69020521_A_T | chr4:69020521 | -26,912 | -11,456 | -13,088 | 1.3e-5 |
| chr4_69020519_A_T | chr4:69020519 | -26,848 | -11,904 | -13,600 | — |
| chr4_69020535_A_T | chr4:69020535 | -26,752 | -11,680 | -13,504 | — |
| chr4_69020544_C_A | chr4:69020544 | -26,176 | -10,464 | -10,848 | — |
| chr4_69020545_A_C | chr4:69020545 | -26,080 | -9,696 | -10,752 | — |
| chr4_69020531_C_A | chr4:69020531 | -25,824 | -10,848 | -13,216 | — |
| chr4_69020424_A_T | chr4:69020424 | 25,664 | 11,104 | 8,832 | — |
| chr4_69020520_A_G | chr4:69020520 | -25,664 | -11,360 | -11,264 | 4.6e-5 |
| chr4_69020519_A_G | chr4:69020519 | -25,632 | -11,616 | -12,480 | — |
| chr4_69020529_T_G | chr4:69020529 | -25,184 | -12,032 | -10,176 | — |
| chr4_69020519_A_C | chr4:69020519 | -25,056 | -11,072 | -12,288 | — |
| chr4_69020493_C_G | chr4:69020493 | 24,960 | 8,224 | 10,816 | — |
| chr4_69020521_A_C | chr4:69020521 | -24,864 | -10,816 | -11,552 | — |
| chr4_69020529_T_C | chr4:69020529 | -24,608 | -10,528 | -11,680 | — |
| chr4_69020479_C_G | chr4:69020479 | 24,416 | 10,528 | 9,376 | — |
| chr4_69020526_G_C | chr4:69020526 | -24,096 | -11,328 | -9,664 | — |
| chr4_69020482_T_G | chr4:69020482 | 24,064 | 9,184 | 7,840 | — |
| chr4_69020487_G_A | chr4:69020487 | 24,032 | 10,688 | 10,304 | 1.3e-5 |
| chr4_69020515_A_G | chr4:69020515 | 23,648 | 9,152 | 6,880 | — |
| chr4_69020551_G_T | chr4:69020551 | -23,648 | -9,952 | -11,456 | — |
| chr4_69020531_C_T | chr4:69020531 | -23,168 | -10,272 | -12,096 | — |
| chr4_69020539_T_A | chr4:69020539 | -23,136 | -8,960 | -12,032 | — |
| chr4_69020535_A_G | chr4:69020535 | -22,688 | -10,208 | -11,200 | 6.6e-6 |
| chr4_69020470_A_T | chr4:69020470 | -22,624 | -9,856 | -8,000 | — |
| chr4_69020487_G_C | chr4:69020487 | 22,560 | 9,696 | 10,048 | — |
| chr4_69020488_A_G | chr4:69020488 | 22,336 | 7,904 | 8,960 | — |
| chr4_69020438_C_G | chr4:69020438 | -22,208 | -9,344 | -6,688 | 3.3e-5 |
| chr4_69020462_T_G | chr4:69020462 | 22,016 | 10,144 | 4,704 | — |
| chr4_69020527_A_T | chr4:69020527 | -21,984 | -10,848 | -11,456 | — |
| chr4_69020501_C_T | chr4:69020501 | -21,824 | -8,768 | -9,440 | — |
| chr4_69020469_A_G | chr4:69020469 | -21,792 | -9,568 | -8,832 | — |
| chr4_69020495_T_A | chr4:69020495 | 21,760 | 8,832 | 8,128 | — |
| chr4_69020496_G_T | chr4:69020496 | -21,600 | -9,600 | -8,672 | — |
| chr4_69020472_G_T | chr4:69020472 | -21,216 | -8,480 | -8,672 | — |
| chr4_69020450_A_G | chr4:69020450 | -21,152 | -10,272 | -7,904 | — |
| chr4_69020438_C_A | chr4:69020438 | -21,120 | -8,512 | -6,656 | 1.3e-5 |
| chr4_69020539_T_C | chr4:69020539 | -21,056 | -8,448 | -10,848 | — |
| chr4_69020489_G_C | chr4:69020489 | 21,024 | 7,232 | 8,032 | — |
| chr4_69020484_T_C | chr4:69020484 | 20,768 | 7,616 | 6,784 | — |
| chr4_69020535_A_C | chr4:69020535 | -20,704 | -8,928 | -9,888 | — |
| chr4_69020543_T_G | chr4:69020543 | 20,320 | 9,184 | 10,816 | — |
| chr4_69020551_G_A | chr4:69020551 | -20,320 | -8,736 | -9,312 | — |
| chr4_69020473_T_G | chr4:69020473 | -20,224 | -7,840 | -8,288 | — |
| chr4_69020477_T_C | chr4:69020477 | 20,224 | 7,968 | 7,104 | — |
| chr4_69020473_T_A | chr4:69020473 | -20,064 | -7,552 | -8,672 | — |
| chr4_69020491_A_C | chr4:69020491 | 20,064 | 7,680 | 8,928 | — |
| chr4_69020438_C_T | chr4:69020438 | -20,032 | -8,416 | -6,176 | — |
| chr4_69020544_C_G | chr4:69020544 | -19,872 | -7,648 | -7,616 | — |
| chr4_69020424_A_C | chr4:69020424 | 19,840 | 7,712 | 5,440 | — |
| chr4_69020539_T_G | chr4:69020539 | -19,808 | -8,512 | -10,272 | — |
| chr4_69020489_G_T | chr4:69020489 | 19,616 | 7,904 | 8,928 | — |
| chr4_69020476_A_G | chr4:69020476 | -19,520 | -8,320 | -5,408 | — |
| chr4_69020445_G_A | chr4:69020445 | -19,200 | -8,576 | -6,912 | — |
| chr4_69020445_G_C | chr4:69020445 | -19,136 | -8,800 | -6,912 | — |
| chr4_69020516_G_A | chr4:69020516 | -18,848 | -7,072 | -6,528 | — |
| chr4_69020469_A_C | chr4:69020469 | -18,784 | -8,032 | -7,200 | — |
| chr4_69020471_A_C | chr4:69020471 | -18,752 | -8,960 | -9,088 | — |
| chr4_69020521_A_G | chr4:69020521 | -18,688 | -7,744 | -7,808 | — |
| chr4_69020490_C_T | chr4:69020490 | 18,592 | 6,240 | 6,144 | — |
| chr4_69020501_C_G | chr4:69020501 | -18,432 | -7,232 | -7,840 | — |
| chr4_69020555_G_T | chr4:69020555 | -18,048 | -8,320 | -8,576 | — |
| chr4_69020452_C_T | chr4:69020452 | 17,792 | 5,472 | 2,048 | — |
| chr4_69020460_C_G | chr4:69020460 | 17,792 | 7,456 | 5,344 | — |
| chr4_69020446_T_A | chr4:69020446 | -17,664 | -8,736 | -6,400 | — |
| chr4_69020445_G_T | chr4:69020445 | -17,600 | -7,904 | -6,144 | — |
| chr4_69020553_T_A | chr4:69020553 | -17,536 | -7,520 | -6,656 | — |
| chr4_69020461_T_G | chr4:69020461 | 17,344 | 7,648 | 5,376 | — |
| chr4_69020562_C_G | chr4:69020562 | 17,120 | 5,376 | 8,160 | — |
| chr4_69020523_T_C | chr4:69020523 | -17,088 | -7,904 | -8,576 | — |
| chr4_69020550_T_A | chr4:69020550 | -17,024 | -6,496 | -5,024 | — |
| chr4_69020468_C_T | chr4:69020468 | -16,896 | -7,072 | -6,912 | — |
| chr4_69020565_T_A | chr4:69020565 | -16,832 | -7,392 | -6,816 | — |
| chr4_69020475_A_T | chr4:69020475 | -16,800 | -7,456 | -8,352 | — |
| chr4_69020550_T_G | chr4:69020550 | -16,800 | -7,072 | -3,744 | — |
| chr4_69020561_T_C | chr4:69020561 | 16,480 | 5,856 | 6,304 | — |
| chr4_69020437_T_C | chr4:69020437 | -16,448 | -6,592 | -5,600 | — |
| chr4_69020470_A_C | chr4:69020470 | -16,448 | -6,816 | -5,248 | — |
| chr4_69020437_T_A | chr4:69020437 | -16,384 | -6,336 | -5,536 | 3.9e-5 |
| chr4_69020474_A_G | chr4:69020474 | -16,352 | -6,816 | -5,280 | — |
| chr4_69020477_T_G | chr4:69020477 | -16,320 | -7,296 | -5,312 | — |
| chr4_69020485_A_G | chr4:69020485 | 16,320 | 6,464 | 5,952 | 6.6e-6 |
| chr4_69020493_C_A | chr4:69020493 | 16,288 | 5,600 | 6,752 | — |
| chr4_69020446_T_G | chr4:69020446 | -16,096 | -7,808 | -4,576 | — |
| chr4_69020601_T_G | chr4:69020601 | -15,968 | -7,168 | -6,432 | — |
| chr4_69020478_A_G | chr4:69020478 | -15,776 | -7,104 | -4,160 | 2.0e-5 |
| chr4_69020547_G_C | chr4:69020547 | 15,776 | 6,816 | 8,768 | 6.6e-6 |
| chr4_69020567_A_C | chr4:69020567 | 15,584 | 6,912 | 6,496 | — |
| chr4_69020500_A_T | chr4:69020500 | 15,552 | 6,912 | 3,936 | — |
| chr4_69020446_T_C | chr4:69020446 | -15,520 | -7,424 | -5,056 | — |
| chr4_69020490_C_A | chr4:69020490 | 15,520 | 5,632 | 5,248 | — |
| chr4_69020527_A_G | chr4:69020527 | -15,424 | -7,424 | -8,064 | — |
| chr4_69020448_A_G | chr4:69020448 | -15,360 | -6,880 | -4,864 | — |
| chr4_69020565_T_C | chr4:69020565 | 15,360 | 4,928 | 4,800 | — |
| chr4_69020576_T_A | chr4:69020576 | -15,360 | -6,304 | -5,184 | — |
| chr4_69020440_A_C | chr4:69020440 | -15,232 | -6,464 | -5,056 | — |
| chr4_69020440_A_T | chr4:69020440 | -15,104 | -6,144 | -4,768 | — |
| chr4_69020449_A_T | chr4:69020449 | -15,040 | -6,400 | -5,856 | — |
| chr4_69020526_G_T | chr4:69020526 | -14,944 | -6,304 | -5,728 | — |
| chr4_69020524_T_G | chr4:69020524 | -14,912 | -6,496 | -5,184 | — |
| chr4_69020569_G_T | chr4:69020569 | -14,912 | -4,864 | -5,216 | — |
| chr4_69020598_T_C | chr4:69020598 | 14,848 | 7,712 | 1,248 | — |
| chr4_69020421_T_G | chr4:69020421 | 14,784 | 5,728 | 5,312 | — |
| chr4_69020574_T_A | chr4:69020574 | -14,784 | -5,920 | -5,408 | — |
| chr4_69020548_A_C | chr4:69020548 | 14,720 | 6,240 | 7,808 | — |
| chr4_69020456_A_C | chr4:69020456 | -14,656 | -6,880 | -5,728 | 2.6e-3 |
| chr4_69020436_A_T | chr4:69020436 | -14,592 | -6,336 | -3,360 | — |
| chr4_69020440_A_G | chr4:69020440 | -14,528 | -5,952 | -4,096 | — |
| chr4_69020494_C_G | chr4:69020494 | 14,496 | 5,472 | 7,456 | 6.6e-6 |
| chr4_69020545_A_G | chr4:69020545 | -14,336 | -5,088 | -5,312 | — |
| chr4_69020447_T_G | chr4:69020447 | -14,112 | -6,560 | -5,344 | — |
| chr4_69020456_A_T | chr4:69020456 | -14,112 | -6,560 | -5,280 | — |
| chr4_69020509_G_T | chr4:69020509 | -14,112 | -5,440 | -7,936 | 4.4e-4 |
| chr4_69020524_T_A | chr4:69020524 | -14,112 | -6,144 | -5,472 | — |
| chr4_69020444_A_T | chr4:69020444 | -14,048 | -5,824 | -4,064 | — |
| chr4_69020542_C_T | chr4:69020542 | -14,048 | -5,472 | -4,192 | — |
| chr4_69020517_A_C | chr4:69020517 | -13,856 | -7,104 | -1,728 | — |
| chr4_69020437_T_G | chr4:69020437 | -13,632 | -5,536 | -3,968 | — |
| chr4_69020579_G_T | chr4:69020579 | -13,600 | -5,856 | -6,208 | — |
| chr4_69020602_G_T | chr4:69020602 | -13,600 | -5,152 | -3,808 | — |
| chr4_69020444_A_C | chr4:69020444 | -13,536 | -5,632 | -3,136 | — |
| chr4_69020651_G_C | chr4:69020651 | 13,472 | 6,048 | 5,408 | — |
| chr4_69020433_A_T | chr4:69020433 | -13,440 | -5,696 | -4,960 | 6.7e-1 |
| chr4_69020447_T_A | chr4:69020447 | -13,408 | -6,208 | -5,376 | — |
| chr4_69020556_A_C | chr4:69020556 | 13,408 | 3,776 | 7,488 | — |
| chr4_69020570_T_A | chr4:69020570 | -13,408 | -6,336 | -3,680 | — |
| chr4_69020491_A_T | chr4:69020491 | 13,376 | 4,864 | 5,248 | — |
| chr4_69020493_C_T | chr4:69020493 | 13,376 | 4,224 | 5,216 | — |
| chr4_69020543_T_A | chr4:69020543 | 13,376 | 5,760 | 5,696 | — |
| chr4_69020490_C_G | chr4:69020490 | 13,152 | 4,192 | 4,064 | — |
| chr4_69020577_T_C | chr4:69020577 | -13,120 | -5,664 | -5,536 | — |
| chr4_69020471_A_T | chr4:69020471 | -13,088 | -6,464 | -6,944 | — |
| chr4_69020442_C_A | chr4:69020442 | 13,056 | 4,000 | 2,080 | — |
| chr4_69020498_G_A | chr4:69020498 | -13,056 | -5,216 | -5,632 | — |
| chr4_69020436_A_C | chr4:69020436 | -12,928 | -5,536 | -2,912 | — |
| chr4_69020456_A_G | chr4:69020456 | -12,864 | -5,824 | -4,672 | — |
| chr4_69020485_A_C | chr4:69020485 | 12,832 | 5,024 | 2,848 | — |
| chr4_69020425_T_A | chr4:69020425 | 12,800 | 5,728 | 6,080 | — |
| chr4_69020448_A_T | chr4:69020448 | -12,800 | -5,728 | -4,352 | — |
| chr4_69020527_A_C | chr4:69020527 | -12,800 | -6,592 | -6,336 | — |
| chr4_69020530_A_G | chr4:69020530 | 12,800 | 4,928 | 3,680 | — |
| chr4_69020569_G_A | chr4:69020569 | -12,672 | -4,480 | -4,800 | — |
| chr4_69020524_T_C | chr4:69020524 | 12,640 | 3,584 | 1,856 | — |
| chr4_69020454_T_G | chr4:69020454 | -12,608 | -5,792 | -4,224 | — |
| chr4_69020457_C_T | chr4:69020457 | -12,544 | -5,056 | -5,824 | — |
| chr4_69020439_A_C | chr4:69020439 | -12,512 | -5,888 | -5,472 | — |
| chr4_69020474_A_T | chr4:69020474 | 12,512 | 5,952 | 6,848 | — |
| chr4_69020450_A_T | chr4:69020450 | 12,480 | 3,968 | 1,408 | — |
| chr4_69020514_G_T | chr4:69020514 | -12,448 | -5,024 | -6,432 | — |
| chr4_69020574_T_G | chr4:69020574 | -12,448 | -5,408 | -4,768 | — |
| chr4_69020476_A_T | chr4:69020476 | -12,288 | -4,768 | -2,304 | — |
| chr4_69020559_T_C | chr4:69020559 | -12,224 | -5,920 | -4,736 | — |
| chr4_69020621_T_G | chr4:69020621 | 12,160 | 4,864 | 3,168 | — |
| chr4_69020510_C_T | chr4:69020510 | -12,096 | -4,320 | -7,392 | — |
| chr4_69020409_C_G | chr4:69020409 | 11,968 | 4,480 | 3,840 | — |
| chr4_69020424_A_G | chr4:69020424 | 11,904 | 4,480 | 3,904 | — |
| chr4_69020480_A_C | chr4:69020480 | 11,808 | 3,744 | 4,192 | — |
| chr4_69020462_T_A | chr4:69020462 | 11,744 | 5,568 | 2,048 | — |
| chr4_69020436_A_G | chr4:69020436 | -11,712 | -5,216 | -3,328 | — |
| chr4_69020579_G_C | chr4:69020579 | -11,680 | -5,056 | -4,704 | — |
| chr4_69020450_A_C | chr4:69020450 | -11,648 | -5,728 | -4,864 | — |
| chr4_69020564_T_G | chr4:69020564 | 11,616 | 4,320 | 5,088 | — |
| chr4_69020439_A_T | chr4:69020439 | -11,552 | -5,280 | -4,896 | — |
Showing 200 of 200 in this window. Scores are the raw center bin Δ, ALT minus REF; click a column to sort.